Genomic dynamics of high-risk carbapenem-resistant klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings DOI Creative Commons
Nehal Adel Abdelsalam, Shahira A. ElBanna, Shaimaa F. Mouftah

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 22, 2024

Abstract Background Ongoing studies have revealed the global prevalence of severe infections caused by hypervirulent strains Klebsiella pneumoniae (K. pneumoniae) . Meanwhile, World Health Organization and Centers for Disease Control declared carbapenem-resistant K. as an urgent public health threat, requiring swift effective action to mitigate its spread. Low- middle-income countries are severely impacted such devastating infectious diseases owing ill implementation antimicrobial practices infection control policies. Having both hypervirulence carbapenemase gene determinants, emergence convergent is now being reported worldwide. Methods In this study, we sequenced 19 carbapenemase-producing recovered from various clinical specimens. Additionally, evaluated phenotypic susceptibility multiple classes using VITEK2 automated system. Utilizing sequencing data, characterized sequence types, serotypes, pangenome, resistance profiles, virulence mobile genetic elements examined isolates. We highlighted high-risk clones carrying determinants among screened Results Our findings that all isolates exhibited either extensive- or pan-drug harbored variants genes spanning nearly classes. The most prevalent detected within were bla NDM−5 OXA−48 identified clones, ST383-K30, ST147-K64, ST11-K15, ST14-K2, which may evolved into putative acquiring full set hypervirulence-associated ( iucABCD , rmpA and/ rmpA2 transporter peg-344 ). study ST709-K9 a clone first time uncovered capsule types K15 K9 carried determinants. frequent Inc found in these Col440I, IncHI1B, FII(K). Conclusion This highlights high-risk, extensively co-carrying Egyptian settings. poses imminent threat not only Egypt but also community, underscoring need enhanced surveillance strategies combat pathogen.

Language: Английский

Epidemiology, antimicrobial resistance profile and management of carbapenem-resistant Klebsiella pneumoniae among mothers with suspected sepsis in Ethiopia DOI Creative Commons
Eshetu Gadisa, Beverly Egyir, Bright Adu

et al.

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 19, 2024

Language: Английский

Citations

2
Multidrug-Resistant Klebsiella pneumoniae and Klebsiella variicola isolated from patients in Portuguese Hospitals: Genomic and Phenotypic Characterization DOI Creative Commons
Joana Castro, Daniela Araújo, Hugo Oliveira

et al.

The Microbe, Journal Year: 2024, Volume and Issue: unknown, P. 100172 - 100172

Published: Sept. 1, 2024

Language: Английский

Citations

2
Production and characterization of biodegradable polymer-polyhydroxybutyrate from agricultural waste-sugarcane bagasse by the novel marine bacterium Klebsiella pneumoniae G1 DOI
Aruna Siripurapu,

Vamsidhar KVN,

Nagaveni Shivshetty

et al.

Bioresource Technology Reports, Journal Year: 2022, Volume and Issue: 20, P. 101268 - 101268

Published: Oct. 31, 2022

Language: Английский

Citations

10
Whole-genome sequencing of Klebsiella pneumoniae MDR circulating in a pediatric hospital setting: a comprehensive genome analysis of isolates from Guayaquil, Ecuador DOI Creative Commons

I Mejía-Limones,

Derly Andrade-Molina, Gabriel Morey-León

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 4, 2024

Language: Английский

Citations

1
Genomic dynamics of high-risk carbapenem-resistant klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings DOI Creative Commons
Nehal Adel Abdelsalam, Shahira A. ElBanna, Shaimaa F. Mouftah

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 22, 2024

Abstract Background Ongoing studies have revealed the global prevalence of severe infections caused by hypervirulent strains Klebsiella pneumoniae (K. pneumoniae) . Meanwhile, World Health Organization and Centers for Disease Control declared carbapenem-resistant K. as an urgent public health threat, requiring swift effective action to mitigate its spread. Low- middle-income countries are severely impacted such devastating infectious diseases owing ill implementation antimicrobial practices infection control policies. Having both hypervirulence carbapenemase gene determinants, emergence convergent is now being reported worldwide. Methods In this study, we sequenced 19 carbapenemase-producing recovered from various clinical specimens. Additionally, evaluated phenotypic susceptibility multiple classes using VITEK2 automated system. Utilizing sequencing data, characterized sequence types, serotypes, pangenome, resistance profiles, virulence mobile genetic elements examined isolates. We highlighted high-risk clones carrying determinants among screened Results Our findings that all isolates exhibited either extensive- or pan-drug harbored variants genes spanning nearly classes. The most prevalent detected within were bla NDM−5 OXA−48 identified clones, ST383-K30, ST147-K64, ST11-K15, ST14-K2, which may evolved into putative acquiring full set hypervirulence-associated ( iucABCD , rmpA and/ rmpA2 transporter peg-344 ). study ST709-K9 a clone first time uncovered capsule types K15 K9 carried determinants. frequent Inc found in these Col440I, IncHI1B, FII(K). Conclusion This highlights high-risk, extensively co-carrying Egyptian settings. poses imminent threat not only Egypt but also community, underscoring need enhanced surveillance strategies combat pathogen.

Language: Английский

Citations

1