A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster

Development, Journal Year: 2023, Volume and Issue: 150(20)

Published: Oct. 5, 2023

ABSTRACT Obesity is linked to reduced fertility in various species, from Drosophila humans. Considering that obesity often induced by changes diet or eating behavior, it remains unclear whether obesity, diet, both reduce fertility. Here, we show females on a high-sugar become rapidly obese and less fertile as result of increased death early germline cysts vitellogenic egg chambers (or follicles). They also have high glycogen, glucose trehalose levels develop insulin resistance their fat bodies (but not ovaries). By contrast, with adipocyte-specific knockdown the anti-obesity genes brummer adipose are but normal Remarkably, supplemented separate source water mostly levels, despite persistent glycogen body resistance. These findings demonstrate affects specific processes oogenesis independently resistance, correlate alone does impair

Language: Английский

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Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inDrosophilafemales

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Summary In Drosophila , adult females store more fat than males. While the mechanisms that restrict body in males are becoming clearer, less is known about how achieve higher storage. Here, we perform a detailed investigation of promote storage females. We show greater intake dietary sugar supports due to female-biased remodeling lipidome. Dietary stimulates female-specific increase insulin-like peptide 3 (Dilp3), which acts together with peripheral insulin sensitivity augment insulin/insulin-like growth factor signaling pathway (IIS) activity Indeed, Dilp3 overexpression prevented decrease after removal sugar. Given adult-specific IIS inhibition caused fat, our data reveal as key determinant female

Language: Английский

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Insulin/Insulin-Like Growth Factor Signaling Pathway Promotes Higher Fat Storage in Drosophila Females

Published: Jan. 1, 2024

Language: Английский

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A high sugar diet, but not obesity, reduces female fertility inDrosophila melanogaster

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 3, 2023

ABSTRACT Many studies from Drosophila to humans show a strong link between obesity and reduced fertility. However, is often induced by changes in diet or eating behavior, such that it remains unclear whether fertility consequence of itself, diet, both. Here, we report high sugar reduces female increasing death early germline cysts (prior follicle formation) degeneration vitellogenic follicles; itself does not impair fertility; glucose levels closely correlate with on diet. Females rapidly develop (and display glycogen, glucose, trehalose levels, insulin resistance) decreased In stark contrast high-sugar-obese females, females which similar are adipocyte-specific knockdown anti-obesity genes brummer adipose have normal metabolic indicators. Remarkably, supplemented separate source water also despite persistent obesity, glycogen resistance markers. These results strengthen our conclusion fertility, an inverse correlation demonstrate signaling remain sufficiently maintain insulin-dependent processes during oogenesis irrespective

Language: Английский

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