Microbial Ecology and Metabolism of Emerging Adulthood: Gut Microbiome Insights from a College Freshman Cohort

Gut Microbes Reports, Journal Year: 2024, Volume and Issue: 1(1), P. 1 - 23

Published: Aug. 19, 2024

The human gut microbiome (GM) undergoes dynamic changes throughout life, transitioning from infancy to adulthood. Despite improved understanding over the past years about how genetics, lifestyle, and external environment impact GM, limited research has explored GM's evolution during late-stage adolescence, especially among college students. This study addresses this gap by investigating longitudinal dynamics of fecal microbial, functional, metabolomic signatures in a diverse group first-year, dormitory-housed A total 485 stool samples 246 participants were analyzed, identifying four primary GM community types, predominantly led

Language: Английский

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Food Insecurity Modifies the Association Between the Gut Microbiome and the Risk of Cognitive Impairment in Adults

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Background Recent studies have shown associations between relative abundances of specific gut microbes and cognitive function; however, few explored the potential interplay microbiome food insecurity in association with risk impairment (RCI). This study investigated role as an effect modifier microbiome, including groups (microbial cliques), RCI. Methods Data came from Survey Health Wisconsin its ancillary Microbiome Study. The analytical sample (n = 360) included adult participants complete data on insecurity, RCI, 16S rRNA sequencing stool samples. A "mini-cog" memory test was implemented to assess Food assessed using a set survey-based questions. Alpha diversity individual taxa RCI were estimated linear regression. Microbial cliques associated identified interpretable machine-learning-based algorithm. All analyses stratified by level, regression models adjusted for relevant confounders. Results status weakly (b 0.06, 95%CI=[0.00, 0.12]). Gut a-diversity had inverse both secure (b=-0.08, 95%CI=[-0.15, -0.02]) insecure (b=-0.09, 95%CI=[-0.26, 0.07]).

Language: Английский

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Comprehensive transcriptomic and metabolomic analyses reveal the link between ferroptosis and gut microbiota in CRC

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 11, 2022

Abstract Objective Given the high incidence rate and mortality of CRC, we constructed a high-performance early diagnosis model based on ferroptosis-related genes explored possible pathway between ferroptosis intestinal microbiota metabolites. Methods To explore associated with gene expression data GSE14297 was extracted from GEO database. A series difference analyses correlation were carried out. Cytoscape used to optimize PPI network, MCODE screen hub modules. 16S rDNA analyze flora. MetaboAnalyst 5.0 metabolites genes. Results Compared normal tissues, 2959 differentially expressed in CRC samples, including 2946 upregulated 13 downregulated 63 overlapping obtained by crossing Further analysis showed that 15 obtained. The ROC curve AUC value NQO1 0.929, other 14 1. GO enrichment modules significantly correlated functions "response oxidative stress", "plasma membrane region" "antioxidant activity". KEGG ferroptosis, metabolic pathways, pathways cancer enriched. Metabolite group, enriched neuroactive ligand-receptor interaction, ABC transporters, aminoacyl tRNA biosynthesis, cocaine addition, central carbon metabolism cancer, information processing, phenylalanine metabolism, biosynthesis amino acids. Analysis metaboanalyst5.0 25 differential Conclusion Based bioinformatics analysis, found be Ferroptosis-related gut microbes may jointly participate progression CRC.

Language: Английский

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