OBM Genetics,
Journal Year:
2023,
Volume and Issue:
07(04), P. 1 - 11
Published: Dec. 14, 2023
Data
from
the
present
study
indicate
that
neonicotinoid
insecticides
Nuprid
200
SL
(with
active
substance
imidacloprid)
and
Calypso
480
SC
thiacloprid)
reduce
mitotic
activity
by
inhibiting
cell
division
increasing
chromosomal
aberrations
in
cells
of
root
apical
meristem
Allium
cepa
L.
The
tested
solutions
pesticides
cause
a
wide
range
anomalies
associated
with
disorders
forming
cell's
apparatus
integrity
chromosomes.
comparative
analysis
their
mutagenic
action
shows
higher
genotoxic
potential
SC.
established
indices
abnormalities
for
are
1.07
±
0.38%
0.70
0.41%
respectively.
mitosodepressant
effect
large
number
when
treated
evidence
high
toxic
significant
risk
environmental
pollution
use
agriculture.
Parts
this
work
was
published
abstract
form
presented
as
an
oral
presentation
at
IV
International
Agricultural,
Biological
&
Life
Science
conference,
Edirne,
Turkey,
2022
August
29-31,
[1]
poster
5th
Balkan
Scientific
Conference
on
Biology,
Plovdiv,
Bulgaria,
2021
April
15-16
[2].
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Dec. 11, 2022
Abstract
In
this
study,
phytochemical
analysis
and
toxicity
profile
of
leaf
flower
extracts
Nerium
oleander
L.
species
collected
from
Giresun
province
(Turkey)
were
investigated.
analyzes,
the
cardiac
glycoside,
alkaloid,
saponin
tannin
contents
analyzed
qualitatively
quantitatively.
The
physiological
effects
determined
by
examining
root
elongation,
weight
gain
germination
rates.
Biochemical
measuring
levels
malondialdehyde
(MDA),
glutathione
(GSH),
superoxide
dismutase
(SOD)
catalase
(CAT),
which
are
indicators
oxidative
stress.
Cytotoxic
genotoxic
investigated
mitotic
index
(MI),
micronucleus
(MN)
chromosomal
abnormality
(CA)
tests.
N.
extract
applications
caused
significant
decreases
in
parameters
Allium
bulbs.
SOD
CAT
activity
tip
cells
increased
significantly
after
application
compared
to
control
group.
Similar
changes
observed
extract,
but
these
increases
found
be
at
a
lower
level
induced
extract.
An
increase
MDA
decrease
GSH
groups
treated
with
extracts.
These
show
that
cause
deterioration
antioxidant/oxidant
balance.
It
was
extracts,
MI
rates
an
MN
CAs
frequencies,
showed
most
prominent
cytotoxic
250
μg/mL
doses.
toxic
associated
content
it
thought
glycosides
alkaloids,
whose
presence
detected
qualitative
quantitative
may
play
important
role
toxicity.
Studies
investigating
therapeutic
properties
plants
as
well
their
insufficient,
leads
fact
exhibiting
potential
not
known.
Therefore,
study
will
lead
many
studies
on
plants.
draw
attention
investigation
similar
studies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8104 - 8104
Published: July 25, 2024
The
present
study
was
aimed
at
assessing
the
impact
of
azoxystrobin-a
fungicide
commonly
used
in
plant
protection
against
pathogens
(Amistar
250
SC)-on
soil
microbiota
and
enzymes,
as
well
growth
development.
laboratory
experiment
conducted
three
analytical
terms
(30,
60,
90
days)
on
sandy
clay
(pH-7.0).
Azoxystrobin
applied
to
doses
0.00
(C),
0.110
(F)
32.92
(P)
mg
kg
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 15, 2024
Abstract
In
this
study,
the
multifaceted
toxicity
induced
by
high
doses
of
essential
trace
element
molybdenum
in
Allium
cepa
L.
was
investigated.
Germination,
root
elongation,
weight
gain,
mitotic
index
(MI),
micronucleus
(MN),
chromosomal
abnormalities
(CAs),
Comet
assay,
malondialdehyde
(MDA),
proline,
superoxide
dismutase
(SOD),
catalase
(CAT)
and
anatomical
parameters
were
used
as
biomarkers
toxicity.
addition,
detailed
correlation
PCA
analyzes
performed
for
all
discussed.
On
other
hand,
study
focused
on
development
a
two
hidden
layer
deep
neural
network
(DNN)
using
Matlab.
Four
experimental
groups
designed:
control
group
bulbs
germinated
tap
water
application
with
1000,
2000
4000
mg/L
72
h.
After
germination,
tips
collected
prepared
analysis.
As
result,
exposure
caused
dose-dependent
decrease
(p
<
0.05)
investigated
physiological
parameter
values,
an
increase
cytogenetic
(except
MI)
biochemical
values.
Molybdenum
different
types
CAs
various
damages
meristem
cells.
assay
results
showed
that
severity
DNA
damage
increased
depending
increasing
dose.
Detailed
analysis
determined
significant
positive
negative
interactions
between
confirmed
relationships
these
doses.
It
has
been
found
DNN
model
is
close
agreement
actual
data
showing
accuracy
predictions.
MAE,
MAPE,
RMSE
R2
to
evaluate
effectiveness
model.
Collective
metrics
well.
it
once
again
cause
multiple
A.
test
reliable
universal
determining
Therefore,
periodic
measurement
levels
agricultural
soils
should
be
first
priority
preventing
Toxicology Research,
Journal Year:
2024,
Volume and Issue:
13(3)
Published: May 1, 2024
Abstract
Zebrafish
being
the
best
animal
model
to
study,
every
attempt
has
been
made
decipher
toxic
mechanism
of
fungicide
usage
and
interest.
It
is
important
understand
multiple
targets
a
toxicant
estimate
potential
in
its
totality.
A
total
22
fungicides
different
classes
like
amisulbrom,
azoxystrobin,
carbendazim,
carboxin,
chlorothalonil,
difenoconazole,
etridiazole,
flusilazole,
fluxapyroxad,
hexaconazole,
kresoxim
methyl,
mancozeb,
myclobutanil,
prochloraz,
propiconazole,
propineb,
pyraclostrobin,
tebuconazole,
thiophanate-methyl,
thiram,
trifloxystrobin
ziram
were
reviewed
analyzed
for
their
explored
zebrafish.
Toxic
end
points
zebrafish
are
highly
informative
when
it
comes
network
analysis.
They
provide
window
into
molecular
cellular
pathways
that
affected
by
certain
toxin.
This
can
then
be
used
gain
insights
underlying
mechanisms
toxicity
draw
conclusions
on
particular
compound
induce
toxicity.
knowledge
inform
decisions
about
drug
development,
environmental
regulation,
other
areas
research.
In
addition,
use
also
better
effects
pollutants
ecosystems.
By
understanding
given
toxin,
researchers
determine
how
may
interact
with
environment
this
could
lead
health
or
impacts.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 27, 2024
Trifloxystrobin
(TFS)
is
a
widely
used
strobilurin
class
fungicide.
Ginkgo
biloba
L.
has
gained
popularity
due
to
its
recognized
medicinal
and
antioxidant
properties.
The
aim
of
this
study
was
determine
whether
extract
(Gbex)
protective
role
against
TFS-induced
phytotoxicity,
genotoxicity
oxidative
damage
in
A.
cepa.
Different
groups
were
formed
from
Allium
cepa
bulbs
subjected
tap
water
(control),
200
mg/L
Gbex
(Gbex1),
400
(Gbex2),
0.8
g/L
TFS
solution
(TFS),
+
(TFS
Gbex1)
Gbex2),
respectively.
phenolic
composition
alterations
the
morphological,
physiological,
biochemical,
anatomical
parameters
evaluated.
Rutin,
protocatechuic
acid,
catechin,
gallic
taxifolin,
p-coumaric
caffeic
epicatechin,
syringic
acid
quercetin
most
prevalent
substances
Gbex.
Rooting
percentage,
root
elongation,
weight
gain,
chlorophyll
b
decreased
by
approximately
50%,
85%,
77%,
55%
70%,
respectively,
as
result
treatment
compared
control.
In
group,
mitotic
index
fell
28%
control
but
chromosomal
abnormalities,
micronuclei
frequency
tail
DNA
percentage
increased.
Fragment,
vagrant
chromosome,
sticky
uneven
chromatin
distribution,
bridge,
vacuole-containing
nucleus,
reverse
polarization
irregular
mitosis
abnormalities
observed
group.
levels
proline
(2.17-fold)
malondialdehyde
(2.71-fold),
well
activities
catalase
(2.75-fold)
superoxide
dismutase
(2.03-fold)
increased
comparison
TFS-provoked
meristematic
disorders
damaged
epidermis
cortex
cells,
flattened
cell
nucleus
thickened
wall.
combined
with
relieved
all
these
stress
signs
dose-dependent
manner.
This
investigation
showed
that
can
play
caused
TFS.
results
demonstrated
had
antigenotoxic
potential
owing
high
content.
