Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 3004 - 3004
Published: Sept. 5, 2024
Autism Spectrum Disorder (ASD) is a multifactorial disorder involving genetic and environmental factors leading to pathophysiologic symptoms comorbidities including neurodevelopmental disorders, anxiety, immune dysregulation, gastrointestinal (GI) abnormalities. Abnormal intestinal permeability has been reported among ASD patients it well established that disturbances in eating patterns may cause gut microbiome imbalance (i.e., dysbiosis). Therefore, studies focusing on the potential relationship between microbiota are emerging. We compared bacteriome mycobiome of cohort subjects with their non-ASD siblings. Differences include significant decrease at phylum level Cyanobacteria (0.015% vs. 0.074%, p < 0.0003), genus Bacteroides (28.3% 36.8%, 0.03). Species-level analysis showed Faecalibacterium prausnitzii, Prevotella copri, fragilis, Akkermansia municiphila. Mycobiome an increase fungal Ascomycota (98.3% 94%, 0.047) Candida albicans (27.1% 13.2%, 0.055). Multivariate organisms from Delftia were predictive increased odds ratio ASD, whereas decreases Azospirillum associated ASD. screened 24 probiotic identify strains could alter growth identified as elevated within subject samples. In preliminary vivo preclinical test, we challenged wild-type Balb/c mice acidovorans (increased subjects) by oral gavage changes behavioral sham-treated controls. An vitro biofilm assay was used determine ability potentially beneficial microorganisms biofilm-forming acidovorans, break down fiber. Downregulation cyanobacteria (generally for inflammation wound healing) combined species such D. suggests ASD-related GI result concomitant pathogens, probiotics can be counteract these changes.
Language: Английский
Citations
6
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 11, 2024
The link between the oral microbiome and neurodevelopmental disorders remains a compelling hypothesis, still requiring confirmation in large-scale datasets. Leveraging over 7000 whole-genome sequenced salivary samples from 2025 US families with children diagnosed autism spectrum (ASD), our cross-sectional study shows that composition can discriminate ASD subjects neurotypical siblings (NTs, AUC = 0.66), 108 differentiating species (q < 0.005). relative abundance of these is highly correlated cognitive impairment as measured by Full-Scale Intelligence Quotient (IQ). IQ 70 also exhibit lower strain sharing parents (p 10
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 12, 2024
Microbiota imbalances are linked to inflammation and disease, as well neurodevelopmental conditions where they may contribute behavioral, physiological, central nervous system dysfunction. By contrast, the role of microbiota in Fetal Alcohol Spectrum Disorder (FASD), group that can occur following prenatal alcohol exposure (PAE), has not received similar attention. Here we utilized a rodent model consumption during pregnancy characterize impact on dam-offspring dyads. Overall, bacterial diversity decreased alcohol-consuming dams community composition differed from controls their offspring. Bacterial taxa predicted biochemical pathway were also altered with consumption/exposure; however, there was minimal overlap between changes These findings illuminate potential importance pathophysiology FASD support investigation into novel microbiota-based interventions.
Language: Английский
Citations
4
Applied Microbiology, Journal Year: 2024, Volume and Issue: 4(4), P. 1677 - 1701
Published: Dec. 16, 2024
Background: Autism spectrum disorder is a multifactorial phenomenon whose genetic, biological, environmental, and nutritional factors outline the heterogeneous phenotype of disease. A limitation in social connections with others, stereotyped reactions, specific interests preferences characterize behavioral manifestations person autism. Also, weaknesses are found emotional, cognitive, metacognitive development, significantly burdening individual’s quality life. Lately, it has gained widespread acceptance that gut microbiome neurotransmission constitute two decisive etiological autism both prenatal period postnatally. This study aims to investigate data on interaction between quantitative qualitative composition flora humans, as well their influences appearance progression symptoms disorder. At same time, captures role digital technology diagnosing intervening autism, which mainly related individual subjects under study. Methods: The current research employs an exploratory review provide concise overview complex neuronal functions associated neurotransmitter action homeostasis mechanisms allow brain human body survive perform optimally. Results: 111 sources highlighted connection dietary habits synthesizing releasing neurotransmitters influence emergence autism-related behaviors. Conclusions: literature review’s findings revealed importance performance behavioral, social, cognitive development among individuals Moreover, noteworthy combining healthy lifestyle targeted use tools can improve intensity symptoms.
Language: Английский
Citations
4
Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Biology, Journal Year: 2025, Volume and Issue: 14(6), P. 593 - 593
Published: May 23, 2025
Fetal alcohol spectrum disorder (FASD) is a significant public health issue that affects children. It results from ethanol exposure during pregnancy, leading to considerable physical, neurodevelopmental, behavioral, and cognitive deficits. The exact mechanism not well understood. Recently, attention has been focused on the influence of gut microbiome brain development through gut–brain axis. Changes in resulting may contribute pathology FASD, potentially involving neuroinflammation. This literature review summarizes existing research primary animal studies impact early microbiome, neuroinflammation, development, behavioral consequences. evidence suggests alters which induce damage, impairment. However, clear causal relationship among these factors remains be fully elucidated.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: March 28, 2024
Abstract CDKL5 deficiency disorder (CDD) is a neurodevelopmental condition characterized by global developmental delay, early-onset seizures, intellectual disability, visual and motor impairments. Unlike Rett Syndrome (RTT), CDD lacks clear regression period. Patients with frequently encounter gastrointestinal (GI) disturbances exhibit signs of subclinical immune dysregulation. However, the underlying causes these conditions remain elusive. Emerging studies indicate potential connection between neurological disorders gut microbiota, an area completely unexplored in CDD. We conducted pioneering study, analyzing fecal microbiota composition individuals (n = 17) their healthy relatives 17). Notably, differences intestinal bacterial diversity were identified patients. In particular, at genus level, microbial communities increase relative abundance Clostridium_AQ , Eggerthella, Streptococcus Erysipelatoclostridium decrease Eubacterium, Dorea, Odoribacter Intestinomonas Gemmiger pointing toward dysbiotic profile. further investigated changes based on severity GI issues, seizure frequency, sleep disorders, food intake type, impairment neuro-behavioral features ambulation capacity. Enrichment Lachnoclostridium Enterobacteriaceae was observed patients more severe symptoms, while Clostridiaceae, Peptostreptococcaceae Coriobacteriaceae Erysipelotrichaceae Christensenellaceae Ruminococcaceae enriched experiencing daily epileptic seizures. Our findings suggest CDD, symptom severity. This study marks first exploration gut-microbiota-brain axis subjects It adds to growing body research emphasizing role opens doors interventions that target microbes aim improving lives
Language: Английский
Citations
3
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 29, 2025
Introduction This protocol outlines the Proyecto Guagua, which aims to explore relationship between characteristics of gut microbiota, parasitic infections, nutritional status, and neurocognitive functioning in school-age children Ecuador. Methods analysis Guagua is a cross-sectional observational study funded by Escuela Superior Politécnica de Chimborazo. It being carried out several counties across different geographical regions Ecuador, including Galápagos. The targets regularly attending school, aged 6–12. We aim recruit 450 children, with data already collected from nearly 300 participants (67%). Enrolled undergo comprehensive evaluations assessing body composition, motor learning, social skills, cognitive ability, sleep habits, physical activity. Caretakers school teachers are interviewed regarding hygiene, eating food handling. Stool samples analyze microbiota determine presence parasites. In phase, we describe differences population structure diversity among undernourished obese/overweight parasitosis compared their peers. also plan test hypothesis that an altered mediates influence malnutrition on parasitosis. Ethics dissemination received ethical approval Committee Universidad Cuenca July 2022. Following pilot addendum minor changes design were approved October Written consent was obtained parents before enrolling study. Parents informed right withdraw at any time. findings “Proyecto Guagua” will be disseminated through open-access, peer-reviewed publications presented local international scientific events.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 545 - 545
Published: Feb. 27, 2025
Given the significance of gut microbiota in autism spectrum disorder (ASD), we aimed to assess quality systematic reviews (SRs) studies assessing and effects probiotic supplementation children with ASD. PubMed, EMBASE, PsycINFO, Medline, Cochrane databases were searched from inception November 2024. We included SRs randomised or non-randomized reporting on probiotics A total 48 (probiotics: 21, microbiota: 27) included. The median (IQR) number participants was 7 (5) 328 (362), respectively, for intervention 18 (18) 1083 (1201), low 12, 14) critically 9, 13) due lack critical items including prior registration, deviation protocol, risk bias assessment studies. Assuring robust methodology future is important generating evidence this field.
Language: Английский
Citations
0
Research in Developmental Disabilities, Journal Year: 2025, Volume and Issue: 161, P. 105003 - 105003
Published: April 6, 2025
Language: Английский
Citations
0