A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY ON STANDARDIZED FENUGREEK SEED EXTRACT COMPOSITION FOR ENDURANCE ENHANCEMENT IN RECREATIONALLY ACTIVE YOUNG SUBJECTS DOI Open Access
Prasad Thakurdesai, Pallavi Deshpande, MADHURA MANDAR KARVE

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2024, Volume and Issue: unknown, P. 155 - 165

Published: Dec. 7, 2024

Objective: To evaluate the efficacy and safety of 8-week supplementation with FEΔE (fenugreek seed extracts composition, standardized to 4-hydroxyisolecuine, trigonelline, select glycosides) on endurance capacity in recreationally active young male subjects, a randomized, double-blind, Placebo-controlled manner. Methods: The 153 participants were randomized equally into three groups received either 300 mg or 600 FeΔE capsules matching Placebo. Each participant performed exercise training four times per week visited study center day recruitment (baseline) end week-4, week-8. outcome measures (overall, cardiovascular, respiratory, metabolic), power, work, physical central fatigue, stress, whereas outcomes adverse events monitoring, compliance, biochemical laboratory measurements. Results: (but not Placebo) showed statistically significant beneficial changes overall (increased time exhaustion total distance run), respiratory oxygen consumption), metabolic equivalent decreased non-esterified fatty acids levels), fatigue (decreased Wingate index), (reduced visual analog score), mental domain score Multidimensional Fatigue Symptom Inventory-Short Form) during within group (vs. baseline) comparisons. did differ between (FEΔE vs. Placebo). Conclusion: Eight weeks resulted comprehensive enhancement, including metabolic, endurance. was found be safe without serious events.

Language: Английский

Automatically Signal-Enhanced Lateral Flow Immunoassay for Ultrasensitive Salivary Cortisol Detection DOI Creative Commons
Seonjong Kim, Min‐Gon Kim

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Competitive lateral flow immunoassay (LFI) is a commonly used platform for detecting cortisol and other small molecules. However, its low sensitivity critical limitation application in point-of-care tests. Thus, various signal enhancement methods have been developed, requiring complex operational steps specialized detectors. In this study, we propose an automatic signal-enhanced LFI (asLFI), providing 100 times improved colorimetric by applying 10,000-fold fewer AuNP conjugates compared to conventional competitive LFI, involving single step. The incorporation of improves the but does not produce visible spontaneously. asLFI facilitates without additional steps, affording signals. demonstrated high (limit detection = 3.8 pg mL-1) across range 0.01-10 ng mL-1 with linearity correlation (R2 0.9159). Furthermore, strong ELISA was observed, validating performance sensor 18 human saliva samples 0.9763). This novel offers simple operation, ultrasensitive tests circadian monitoring cortisol.

Language: Английский

Citations

0
Ferulic acid protects against stress-induced myocardial injury in mice DOI

Siyong Li,

Peiyi He,

Jiahe Liu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: 498, P. 117309 - 117309

Published: March 20, 2025

Language: Английский

Citations

0
A randomised controlled trial assessing the effects of weather sensitivity profile and walking in nature on the psychophysiological response to stress in individuals with coronary artery disease. A study protocol DOI Creative Commons
Dalia Martinaitienė, Francisco Sampaio, Zsolt Demetrovics

et al.

BMC Psychology, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 19, 2024

The following protocol pertains to a pioneer study, aiming investigate how weather sensitivity and walking in different environments affects the psychophysiological responses stress of individuals with coronary artery disease (CAD) during rehabilitation (WE_SENSE_THE_NATURE). This randomised control trial will provide fresh insight on influence environmental exposure CAD patients, as it is seldom investigated association disease. Additionally, findings link between personality traits cognitive functions (especially flexibility), may help reveal fine-grained perspective treatment possibilities for at risk stress-vulnerability. proposed among attending cardiac program. We aim recruit 164 individuals, collecting information related demographic characteristics, sensitivity, functional capacity, traits, subjective mental health status, function, basal cortisol level participating individuals. Basal refers concentration saliva be tested morning afternoon prior day experiment. After baseline measurements, patients randomly assigned either outdoors or indoors. All measures their sequential order remain same within each group, while condition (i.e., environment) vary groups. On experiment, hemodynamic parameters (assessed via 6-hour blood pressure measurements), (consisting assessments level), mood using visual analogues scale) registered. Cold test administered evaluate effect environments. outcomes this study have direct clinical applications use types exercise programs. Awareness about potential reactions contribute timely planning implementation actions leading improved medical care services preventive measures, especially considering expected oscillations extreme events due unfolding climate change. has been retrospectively registered ClinicalTrials.gov identifier code: NCT06139705 November 20, 2023.

Language: Английский

Citations

2
Relationship between subjective and objective fatigue and sleep characteristics in individuals with anxiety and mood disorders: An exploratory study DOI
Agnė Stanytė, Aurelija Podlipskytė, Audrius Alonderis

et al.

Physiology & Behavior, Journal Year: 2023, Volume and Issue: 274, P. 114429 - 114429

Published: Dec. 6, 2023

Language: Английский

Citations

5
A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis DOI Creative Commons
Hamdi Ben Halima,

Nadia Zine,

J. Bausells

et al.

Micromachines, Journal Year: 2022, Volume and Issue: 13(12), P. 2235 - 2235

Published: Dec. 16, 2022

Assessing cortisol levels in human bodies has become essential to diagnose heart failure (HF). In this work, we propose a salivary detection strategy as part of an easily integrable lab-on-a-chip for HF biomarkers. Our developed capacitive immunosensor based on hafnium oxide (HfO2)/silicon structure showed good linearity between increasing concentration and the charge-transfer resistance/capacitance. Moreover, biosensor was demonstrated be highly selective toward compared other biomarkers such tumor necrosis factor (TNF-α) N-terminal pro-brain natriuretic peptide (NT-proBNP). The precision our evaluated, difference determined saliva its expected one is <18%.

Language: Английский

Citations

5
One-Drop Enhancement Trap Lateral Flow Immunoassay for Detection of Salivary Cortisol DOI
Seonjong Kim, Min‐Gon Kim

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Automatically Signal-Enhanced Lateral Flow Immunoassay for Ultra-Sensitive Detection of Salivary Cortisol DOI
Seonjong Kim, Min‐Gon Kim

Published: Jan. 1, 2024

Language: Английский

Citations

0
The risk of coronary artery disease in patients with type 2 diabetes mellitus and metabolic syndrome DOI Creative Commons
N.V. Chmyr, R.Ya. Dutka, H.V. Svitlyk

et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2024, Volume and Issue: 20(4), P. 278 - 285

Published: Aug. 2, 2024

Background. The relevance of this work is due to the growing need for a personalized approach management patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) that arose on background metabolic syndrome (MS) determining individual risk each patient. purpose study was find out methodology complications in patient using lipid, carbohydrate hormonal parameters. Materials methods. A 319 MS conducted. Six clinical groups were formed. first group included 82 MS, second — 39 T2DM (compensation state) third 35 (decompensation fourth 44 CAD fifth sixth 75 MS. control consisted 40 healthy individuals. Women accounted 69.9 % all men 30.1 %. (with/without T2DM) calculated above indicators further construction prognostic probability model. Results. Patients had pronounced changes metabolism presence decompensation. Changes lipid among (state decompensation) turned be non-specific. Interrelated thyroid-stimulating hormone, cortisol, prolactin, insulin revealed depending form severity syntropic pathology. Given parameters, model diabetes) calculated. Fifteen factors selected, which, according our own observations, could influence development At same time, 10 identified reliable CAD. preventive nature high-density lipoprotein cholesterol prolactin (in women) effect occurrence provoking diabetes, age, triglyceride, cortisol levels, body mass index, glycated hemoglobin revealed. Their regression coefficients determined, reliability checked Wald method, whole chi-square, accuracy 79.4 %, specificity 77.3 sensitivity 81.9 Conclusions. an increase level HOMA-IR, shift spectrum; women, hormone against normal values free thyroxine. Decompensation accompanied by at levels contrast state compensation, women significantly increased, regardless compensation. method calculating anthropometric indicators, spectrum, proposed.

Language: Английский

Citations

0
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY ON STANDARDIZED FENUGREEK SEED EXTRACT COMPOSITION FOR ENDURANCE ENHANCEMENT IN RECREATIONALLY ACTIVE YOUNG SUBJECTS DOI Open Access
Prasad Thakurdesai, Pallavi Deshpande, MADHURA MANDAR KARVE

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2024, Volume and Issue: unknown, P. 155 - 165

Published: Dec. 7, 2024

Objective: To evaluate the efficacy and safety of 8-week supplementation with FEΔE (fenugreek seed extracts composition, standardized to 4-hydroxyisolecuine, trigonelline, select glycosides) on endurance capacity in recreationally active young male subjects, a randomized, double-blind, Placebo-controlled manner. Methods: The 153 participants were randomized equally into three groups received either 300 mg or 600 FeΔE capsules matching Placebo. Each participant performed exercise training four times per week visited study center day recruitment (baseline) end week-4, week-8. outcome measures (overall, cardiovascular, respiratory, metabolic), power, work, physical central fatigue, stress, whereas outcomes adverse events monitoring, compliance, biochemical laboratory measurements. Results: (but not Placebo) showed statistically significant beneficial changes overall (increased time exhaustion total distance run), respiratory oxygen consumption), metabolic equivalent decreased non-esterified fatty acids levels), fatigue (decreased Wingate index), (reduced visual analog score), mental domain score Multidimensional Fatigue Symptom Inventory-Short Form) during within group (vs. baseline) comparisons. did differ between (FEΔE vs. Placebo). Conclusion: Eight weeks resulted comprehensive enhancement, including metabolic, endurance. was found be safe without serious events.

Language: Английский

Citations

0