Microstructural white matter alterations associated with social anxiety disorders: A systematic review

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 78 - 88

Published: Jan. 13, 2024

Language: Английский

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Pre-scan state anxiety is associated with greater right amygdala-hippocampal response to fearful versus happy faces among trait-anxious Latina girls

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 2, 2024

Abstract Background Unfamiliarity with academic research may contribute to higher levels of anticipatory state anxiety about affective neuroimaging tasks. Children high trait display differences in brain response fearful facial affect compared non-anxious youth, but little is known the influence on this association. Because reduced engagement scientific and greater mistrust among minoritized groups lead systematic pre-scan anxiety, it crucial understand neural correlates during emotion processing so as disambiguate sources individual differences. Methods The present study probed interactive effects emotional valence (fearful vs. happy faces) activation implicit a community sample 46 preadolescent Latina girls (8–13 years). Results Among mean was associated right amygdala-hippocampal left inferior parietal lobe faces relative faces. Conclusions Anticipatory scanning context cause children moderate be hypervigilant threats, further compounding anxiety. Neuroimaging researchers should control for that resulting from MRI apprehension are not misleadingly attributed demographic or environmental characteristics.

Language: Английский

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High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging

NeuroImage, Journal Year: 2023, Volume and Issue: 275, P. 120191 - 120191

Published: May 25, 2023

Healthy neurocognitive aging has been associated with the microstructural degradation of white matter pathways that connect distributed gray regions, assessed by diffusion-weighted imaging (DWI). However, relatively low spatial resolution standard DWI limited examination age-related differences in properties smaller, tightly curved fibers, as well more complex microstructure matter. Here, we capitalize on high-resolution multi-shot DWI, which allows resolutions < 1 mm3 to be achieved clinical 3T MRI scanners. We whether traditional diffusion tensor-based measures and graph theoretical structural connectivity (1.5 voxels, 3.375 μl volume) (1 1μl were differentially related age cognitive performance 61 healthy adults 18-78 years age. Cognitive was using an extensive battery comprising 12 separate tests fluid (speed-dependent) cognition. Results indicated data had larger correlations between mean diffusivity, but smaller connectivity. Moreover, parallel mediation models including both revealed only mediated These results lay groundwork for future studies planning apply methodology further assess mechanisms impairment.

Language: Английский

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Ethnic–Racial Discrimination Exposure and Anxiety in Latina Girls: Amygdala Volume as an Indirect Neurobiological Pathway

KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie, Journal Year: 2024, Volume and Issue: 76(3), P. 627 - 648

Published: April 8, 2024

Abstract Ethnic–racial discrimination, the differential treatment of individuals based on ethnic or racial group membership, predicts poor mental health outcomes such as anxiety. This is supported by long-standing theories social determinants and minority stress. However, these are rarely expanded to neurobiological sciences, limiting our understanding mechanisms underlying observed associations. One potential pathway between ethnic–racial discrimination exposure anxiety that ongoing racially charged encounters presents imminent threats may modify stress-sensitive neurocircuitry, like amygdala. The current study evaluated whether amygdala volume mediated associations symptoms in Latina girls, a exhibiting heightened levels untreated disproportionately subjected discrimination. Thirty predominantly Mexican-identifying girls residing Southern California ( M Age = 9.76, SD 1.11 years) completed T1-weighted structural MRI scan. Using Perceptions Racism Children Youth , participants self-reported prevalence severity various discriminatory experiences. Participants also their via Screen for Child Anxiety Related Emotional Disorders. Controlling total intracranial annual household income, an indirect effect left was observed, β −0.28, SE 0.17, BC 95% CI [−0.690, −0.017]. findings suggest sensitive racialized childhood stress-related alterations may, part, contribute elevated girls. Our data elucidate mechanism which this form sociocultural stress can adversely impact health, particularly transition from middle early adolescence, period marked host interlinked neurophysiological changes.

Language: Английский

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The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(7), P. 585 - 603

Published: June 24, 2024

Language: Английский

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Caregiver experienced racism, acculturative stress, and political hostility predict anxiety in Latinx families residing in the United States.

Cultural Diversity & Ethnic Minority Psychology, Journal Year: 2024, Volume and Issue: 30(4), P. 792 - 804

Published: July 8, 2024

Cultural stress potently predicts mental health inequities, such as anxiety, among adult and adolescent immigrants in the United States. However, less work has focused on preadolescence, a period marked by neurodevelopmental psychosocial changes that can exacerbate anxiety symptoms. Latina girls, who exhibit heightened levels of untreated may be at elevated risk. The present study tests whether cultural symptoms girls their caregivers.

Language: Английский

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Neural Substrates of Emotion Processing and Cognitive Control Over Emotion in Youth Anxiety: An RDoC-Informed Study Across the Clinical to Nonclinical Continuum of Severity

Journal of the American Academy of Child & Adolescent Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

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A preliminary study of threat-anticipatory responding in Latina youth: associations with age, anxiety, and cortical thickness

Social Cognitive and Affective Neuroscience, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Variation in prefrontal cortex neuroanatomy has been previously associated with elevated physiological responses to anticipated aversive events. The extent which such associations extend beyond the specific ecology of treatment-seeking youth from upper-middle socioeconomic backgrounds is unknown. current study tests replicability neuroanatomical correlates anticipatory responding and moderating roles age anxiety severity a community sample Latina girls, historically underrepresented group exhibiting high levels untreated anxiety. Forty pre-adolescent girls (MAge = 10.01, s.d. 1.25, range 8-12 years) completed structural magnetic resonance imaging scan. Participants also differential threat safety learning paradigm, during skin conductance subjective fear were assessed. Anxiety was assessed via Screen for Child Related Emotional Disorders. Ventromedial thickness reduced responsivity threat. Age- anxiety-dependent emerged between dorsomedial individual differences This preliminary extends work on contributions highlights potential considerations early identification efforts this population when neurocircuitry still developing.

Language: Английский

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Neural Markers of Treatment Response in Pediatric Anxiety and PTSD

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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