Cited by Clarifying new molecular subtyping and precise treatment of melanoma based on disulfidptosis-related lncRNA signature

Disulfidptosis-related lncRNA signatures assess immune microenvironment and drug sensitivity in hepatocellular carcinoma DOI

Kequan Xu,

Caixia Dai,

Jialing Yang

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 169, P. 107930 - 107930

Published: Jan. 4, 2024

Language: Английский

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Analyzing the impact of metabolism on immune cells in tumor microenvironment to promote the development of immunotherapy DOI

Yanru Long,

Houhui Shi,

Yuedong He

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Tumor metabolism and tumor immunity are inextricably linked. Targeting the of tumors is a point worth studying in immunotherapy. Recently, influence immune cells on occurrence, proliferation, metastasis, prognosis has attracted more attention. tissue forms specific microenvironment (TME). In addition to cells, there also stromal other TME. To adapt environment, go through reprogramming various substances. The may further affect formation function variety especially eventually promoting development. Therefore, it necessary study its effects guide Inhibiting restore balance promote response tumors. This article will describe glucose metabolism, lipid amino acid Besides, impact TME discussed for analyzing exploring

Language: Английский

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Lipid Metabolism as a Potential Target of Liver Cancer DOI

Kangze Wu, Feizhuan Lin

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 327 - 346

Published: Feb. 1, 2024

Abstract: Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving prognosis HCC remains formidable challenge. It is noteworthy that lipid metabolism plays pivotal role onset, development, progression cells. Existing research indicates potential application targeting HCC. This review aims to thoroughly explore alterations HCC, offering detailed account advantages associated innovative therapeutic strategies metabolism. Targeting holds promise for potentially enhancing Keywords: cholesterol, fatty acid, hepatocellular carcinoma, uptake, catabolism, synthesis

Language: Английский

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LncRNA RP11-620J15.3 promotes HCC cell proliferation and metastasis by targeting miR-326/GPI to enhance glycolysis DOI

Chuanjiang Liu,

Kequan Xu,

Jiayin Liu

et al.

Biology Direct, Journal Year: 2023, Volume and Issue: 18(1)

Published: April 5, 2023

Abstract Background Accumulating studies have demonstrated that the Warburg effect plays a central role in occurrence and development of hepatocellular carcinoma (HCC), albeit non-coding RNA (lncRNA) its association remains unclear. Methods The Zhengzhou University People’s Hospital kindly provided 80 pairs HCC tissues their matched paracancerous for this study. Bioinformatics analysis, real-time quantitative polymerase chain reaction, Western blotting, oncology functional assays were performed to determine contribution RP11-620J15.3 HCC. mechanism co-immunoprecipitation luciferase reporter gene was employed ascertain how interacts with important molecular targets. Results Our results revealed lncRNA termed overexpressed substantially associated tumor size. A high expression mRNA found be significantly worsening prognosis patients. We discovered stimulated glycolytic pathway cells by RNA-sequencing (RNA-seq) metabolomics analyses. Mechanistically, acted as competitive endogenous regulate GPI sponging miR-326 In addition, TBP transcription factor RP11-620J15.3, which contributed cells. Conclusion Based on our findings, is novel LncRNA positively regulates progression. Specifically, RP11-620J15.3/miR-326/GPI promotes malignant progression regulating glycolysis, thereby providing targets treatment drug development.

Language: Английский

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Unveiling the role of disulfidptosis-related genes in the pathogenesis of non-alcoholic fatty liver disease DOI

Xiaohua Luo,

Junjie Guo,

Hongbo Deng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 15, 2024

Non-alcoholic fatty liver disease (NAFLD) presents as a common characterized by an indistinct pathogenesis. Disulfidptosis is recently identified mode of cell death. This study aimed to investigate the potential role disulfidptosis-related genes (DRGs) in pathogenesis NAFLD.

Language: Английский

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Machine learning-based integration reveals reliable biomarkers and potential mechanisms of NASH progression to fibrosis DOI

Jiahui Feng,

Zheng Gong, Jia‐Ling Yang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 11, 2025

Language: Английский

Citations

Machine learning-based prognostic modelling of NK cells in PAAD for immunotherapy guidance DOI

Li Li,

Wu Zz,

Wanxing Duan

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 20, 2025

Language: Английский

Citations

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma DOI

Ren-Yong Wang,

Jia‐Ling Yang, Ning Xu

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(8), P. 919 - 942

Published: Feb. 26, 2024

Hepatocellular carcinoma (HCC) is one of the most common types tumors. The influence lipid metabolism disruption on development HCC has been demonstrated in published studies.

Language: Английский

Citations

Significance of Malic Enzyme 1 in Cancer: A Review DOI

Rina Fujiwara‐Tani,

Chie Nakashima,

Hitoshi Ohmori

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 83 - 83

Published: Jan. 29, 2025

Malic enzyme 1 (ME1) plays a key role in promoting malignant phenotypes various types of cancer. ME1 promotes epithelial–mesenchymal transition (EMT) and enhances stemness via glutaminolysis, energy metabolism reprogramming from oxidative phosphorylation to glycolysis. As result, the cancer cells poor patient prognosis. In particular, expression is promoted hypoxic environments associated with hypoxia-inducible factor (HIF1) α. overexpressed budding at invasive front, invasion metastasis. also generates nicotinamide adenine dinucleotide (NADPH), which, together glucose-6-phosphate dehydrogenase (G6PD) isocitrate (IDH1), expands NADPH pool, maintaining redox balance cells, suppressing cell death by neutralizing mitochondrial reactive oxygen species (ROS), stemness. This review summarizes latest research insights into mechanisms which contributes progression. Because involved aspects many its phenotypes, it expected that will become novel drug target near future.

Language: Английский

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Lipid Metabolism and Immune Response in Hepatocellular Carcinoma: Interplay Driving Tumor Progression DOI

Tiffany Ching-Yun Yu, Yu‐Man Tsui, Xin Zhang

et al.

Published: April 4, 2025

With the rising incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), it has become a significant risk factor for hepatocellular carcinoma (HCC). This review focuses on roles lipid metabolism aberrations and reprogramming in HCC development. We begin with brief overview relevant lipids to HCC, including fatty acyls, glycerolipids, glycerophospholipids sterol lipids, discuss particularly how associated its promotes chemoresistance HCC. then explore heterogeneity distribution across different stages includes intra-tissue spatial histological structure zonated regions liver, interpatient tumor at various degrees resolutions, from single cell bulk tissue levels. Next, we describe plasticity MASLD advent immunotherapy also examine relationship between anti-tumor immunity Finally, address challenges future perspectives targeting as dual approach improve treatment.

Language: Английский

Citations