COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis (Preprint) DOI Creative Commons

Tahani Al Rahbeni,

Prakasini Satapathy, Ramaiah Itumalla

et al.

Published: Nov. 21, 2023

BACKGROUND The unprecedented emergence of the COVID-19 pandemic necessitated development and global distribution vaccines, making understanding vaccine acceptance hesitancy crucial to overcoming barriers vaccination achieving widespread immunization. OBJECTIVE This umbrella review synthesizes findings from systematic reviews meta-analyses provide insights into perceptions on across diverse populations regions. METHODS We conducted a literature search major databases identify meta-analysis that reported hesitancy. AMSTAR-2 (A Measurement Tool Assess Systematic Reviews) criteria were used assess methodological quality included reviews. Meta-analysis was performed using STATA 17 with random effect model. data synthesis is presented in table format via narrative. RESULTS Our inclusion met by 78 published between 2021 2023. analysis revealed moderate rate 63% (95% CI 0.60%-0.67%) general population, significant heterogeneity (<i>I</i><sup>2</sup> = 97.59%). Higher rates observed among health care workers individuals chronic diseases, at 64% 0.57%-0.71%) 69% 0.61%-0.76%), respectively. However, lower noted pregnant women, 48% 0.42%-0.53%), parents consenting for their children, 61.29% 0.56%-0.67%). pooled 32% 0.25%-0.39%) population. assessment 19 high-quality, 38 moderate-quality, 15 low-quality, 6 critically low-quality meta-analyses. CONCLUSIONS presence globally, emphasizing necessity population-specific, culturally sensitive interventions clear, credible information dissemination foster acceptance. disparities accentuate need continuous research understand evolving address unique concerns needs populations, thereby aiding formulation effective inclusive strategies. CLINICALTRIAL PROSPERO CRD42023468363; https://tinyurl.com/2p9kv9cr

Language: Английский

COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis DOI Creative Commons

Tahani Al Rahbeni,

Prakasini Satapathy, Ramaiah Itumalla

et al.

JMIR Public Health and Surveillance, Journal Year: 2024, Volume and Issue: 10, P. e54769 - e54769

Published: April 30, 2024

The unprecedented emergence of the COVID-19 pandemic necessitated development and global distribution vaccines, making understanding vaccine acceptance hesitancy crucial to overcoming barriers vaccination achieving widespread immunization.

Language: Английский

Citations

13
Enablers and barriers to vaccine uptake and handwashing practices to prevent and control COVID-19 in Kenya, Uganda, and Tanzania: a systematic review DOI Creative Commons

Josphat Martin Muchangi,

James Mturi,

Hajra Mukasa

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 27, 2024

The global emergence of coronavirus disease 2019 (COVID-19) posed unprecedented challenges, jeopardizing decades progress in healthcare systems, education, and poverty eradication. While proven interventions such as handwashing mass vaccination offer effective means curbing COVID-19 spread, their uptake remains low, potentially undermining future pandemic control efforts. This systematic review synthesized available evidence the factors influencing vaccine practices Kenya, Uganda, Tanzania context prevention control. We conducted an extensive literature search across PubMed, Science Direct, Google Scholar databases following Preferred Reporting Items for Systematic Review Meta-Analysis (PRISMA) guidelines. Out 391 reviewed articles, 18 were eligible inclusion. Some common barriers to included lack trust government’s recommendations or messaging on benefits hand hygiene access water, while some safety efficacy concerns inadequate awareness sites types. Enablers encompassed programs soap water those improved knowledge and, socio-economic like a higher level education. underscores pivotal role addressing these capitalizing enablers promote practices. Stakeholders should employ campaigns community engagement, ensure resources’ accessibility, leverage incentives Clinical trial registration : [ https://clinicaltrials.gov/ ], identifier [CRD42023396303].

Language: Английский

Citations

1
Identifying and overcoming COVID-19 vaccination impediments using Bayesian data mining techniques DOI Creative Commons
Bowen Lei, Arvind Mahajan, Bani K. Mallick

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 13, 2024

Abstract The COVID-19 pandemic has profoundly reshaped human life. development of vaccines offered a semblance normalcy. However, obstacles to vaccination have led substantial loss life and economic burdens. In this study, we analyze data from prominent health insurance provider in the United States uncover underlying reasons behind inability, refusal, or hesitancy receive vaccinations. Our research proposes methodology for pinpointing affected population groups suggests strategies mitigate barriers hesitations. Furthermore, estimate potential cost savings resulting implementation these strategies. To achieve our objectives, employed Bayesian mining methods streamline dimensions identify significant variables (features) influencing decisions. Comparative analysis reveals that method outperforms cutting-edge alternatives, demonstrating superior performance.

Language: Английский

Citations

1
Attitude toward vaccination against COVID-19 and acceptance of the national “QazVac” vaccine in the Aktobe city population, West Kazakhstan: A cross-sectional survey DOI Creative Commons
Saltanat T. Urazayeva,

Saulesh Kurmangaliyeva,

Asset A. Kaliyev

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0303854 - e0303854

Published: May 16, 2024

The scale of emergency caused by COVID-19, the ease survey, and crowdsourcing deployment guaranteed latest technology have allowed unprecedented access to data describing behavioral changes induced pandemic. study aimed present survey results identifying attitudes toward vaccination against COVID-19 among population West Kazakhstan, level confidence in national QazVac vaccine, role different sources information on decision-making concerning vaccination. A computer-assisted was conducted using WhatsApp messenger. Overall, 2,009 participants responded, with a response rate 92%. Most (83.1%) were immunized COVID-19; them, 20.1% obeyed request their employers that had been practiced within non-pharmaceutical interventions contain disease. youngest respondents, individuals college education, students, employed people, as well those chronic diseases, showed positive (all p<0.05). About two-thirds respondents (69.2%) expressed trust all types vaccines COVID-19. Of who refused (16.9%), about one-third feared consequences, more than third (38.2%) reported anti-vaccine sentiments. decisive factors accepting official (reports medical experts, etc.) and, mainly, subjectively interpreted sufficiency disease, which increased odds being vaccinated 63.9% (OR 1.71, 95% CI [1.3;2.26], Confidence domestic vaccine 37.7% respondents. History severity disease did not play perceptions vaccination, while illness after substantially affected approval (p 0.021). No significant differences observed regarding overall performance across five (QazVac, Sputnik V, CoronaVac, Hayat-Vax, BioNTech/Pfizer) available for Kazakhstan’s 0.27).

Language: Английский

Citations

1
Vaccine hesitancy in context of COVID-19 in East Africa: systematic review and meta-analysis DOI Creative Commons
Melsew Setegn Alie, Gossa Fetene Abebe, Yilkal Negesse

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 12, 2024

The outbreak of the SARS-CoV-2 pandemic has had a significant impact on human lives, and development effective vaccines been promising solution to bring an end pandemic. However, success vaccination program heavily relies portion population being vaccinated. Recent studies have indicated rise in vaccine hesitancy over time inconsistent factors affecting it. This study aimed synthesis pooled prevalence COVID-19 associated among various communities East Africa. review encompassed relevant descriptive observational conducted between January 1, 2020, December 26, 2023. We browsed databases, including PubMed, Google Scholar, Scopus, African online Journal, cross-references, Web Science. After extracted exported R data analysis was performed using version 4.2. Meta-package were used estimate hesitancy. Publication bias assessed through funnel plots, Egger's test, trim-and-fill methods. carefully screening initial pool 53,984 studies, total 79 included this systematic meta-analysis. overall 40.40% (95% CI: 35.89%; 45.47%, I2: 99.5%). Identified influencing hesitance female sex, under 40 years old, inadequate prevention practices, relying web/internet as source information, having negative attitude towards vaccine, uncertainty about safety, fear adverse effects, contracting COVID-19, belief conspiracy myths. Approximately four out ten individuals region express vaccination. A tailored approach that considers socio-demographic context could significantly reduce To achieve high coverage, comprehensive strategy is essential, necessitating substantial social, scientific, health efforts. campaigns within widespread consistent implementation interventions. Registered PROSPERO with ID: CRD42024501415.

Language: Английский

Citations

0
Kenyans’ Perceptions of the Risks of COVID-19 Vaccines: A Scoping Review DOI Creative Commons

Faith Anyango Ochieng’,

Dónal P O’Mathúna

Pan-African Journal of Health and Environmental Science, Journal Year: 2024, Volume and Issue: 3(2), P. 21 - 38

Published: Dec. 26, 2024

Background: Vaccination programs are critical in controlling the spread of viral diseases worldwide. The COVID-19 pandemic underscored role vaccines. Achieving widespread immunization is significantly challenged by vaccine hesitancy, particularly concerns regarding potential risks. perceptions Kenyans risks vaccines were explored this scoping review. Methods: Arksey and O’Malley framework Joanna Briggs Institute methodology used. A search strategy was developed to identify peer-reviewed publications relevant grey literature from electronic databases Google. Identified articles screened using inclusion exclusion criteria. Data extracted analyzed themes. Results: Twenty-eight included most common themes leading hesitancy among safety, side effects, lack knowledge about Four other identified discussed. Conclusion: This review adds our understanding factors influencing during public health emergencies Kenya. Public messaging should prioritize addressing these while also advocating for equitable access benefits vaccination.

Language: Английский

Citations

0
Levels of handwashing and vaccine uptake in Kenya, Uganda, and Tanzania to prevent and control COVID-19: a systematic review and meta-analysis DOI Creative Commons

Josphat Martin Muchangi,

James Mturi,

Hajra Mukasa

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Nov. 9, 2023

Introduction Coronavirus Disease 2019 (COVID-19) presents a massive challenge in Africa due to overwhelmed and underresourced health systems, as well the existing burden of communicable non- diseases. Self-inoculation may occur when an individual touches their mucous membrane following direct contact between hands severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-contaminated surfaces. Therefore, handwashing can be used along with COVID-19 vaccines reduce spread SARS-CoV-2 COVID-19. We were interested investigating levels vaccine uptake control prevent Kenya, Uganda Tanzania using systematic review meta-analysis. Methods searched PubMed, African Index Medicus Journals Online for studies published since inception 31 st January 2023. included all that assessed: acceptance hesitance indicators uptake; on Tanzania. Study findings synthesized by meta-analysis get pooled effect measure. Three qualitatively high level heterogeneity measure precluding quantitative Results Our search identified 128 articles which 17 18,305 participants 622 vaccination sites reviewed 14 them being meta-analyzed. This reports at 67% (95% CI: 55, 78) 88% 73, 97), respectively. Vaccine among was low 31% 15, 49). Discussion Despite importance prevention COVID-19, some countries do not implement effectively. There is need public strategies raise awareness about vaccine. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/ , PROSPERO ID CRD42023394698.

Language: Английский

Citations

1
Levels of handwashing and vaccine uptake in Kenya, Uganda, and Tanzania to prevent and control COVID-19: a systematic review and meta-analysis DOI Creative Commons

Josphat Martin Muchangi,

James Mturi,

Hajra Mukasa

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 19, 2023

Abstract Introduction: Coronavirus Disease 2019 (COVID-19) presents a massive challenge in Africa due to overwhelmed and underresourced health systems, as well the existing burden of communicable non- diseases. Self-inoculation may occur when an individual touches their mucous membrane following direct contact between hands severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-contaminated surfaces. Therefore, handwashing can be used along with COVID-19 vaccines reduce spread SARS-CoV-2 COVID-19. We were interested investigating levels vaccine uptake control prevent Kenya, Uganda Tanzania using systematic review meta-analysis. Methods: searched PubMed, African Index Medicus Journals Online for studies published since inception 31 st January 2023. included all that assessed: acceptance hesitance indicators uptake; on Tanzania. Study findings synthesized by meta-analysis get pooled effect measure. Three qualitatively high level heterogeneity measure precluding quantitative Results: Our search identified 128 articles which 17 18,305 participants 622 vaccination sites reviewed 14 them being meta-analyzed. This reports at 67% (95% CI: 55, 78) 88% 73, 97), respectively. Vaccine among was low 31% 15, 49). Conclusions: Despite importance prevention COVID-19, some countries do not implement effectively. There is need public strategies raise awareness about vaccine. Registration: PROSPERO ID CRD42023394698; registered 6 th

Language: Английский

Citations

0
Evaluation And Determination Of The Phytotherapeutic Properties Of Selected Plants And Their Bioactive Metabolites On Targeted Genes In Colorectal Cancer Management DOI Open Access
John M. Macharia

Published: Jan. 1, 2023

This extensive research aimed to evaluate and determine the phytotherapeutic properties of selected plants their bioactive metabolites on targeted genes in colorectal cancer (CRC) management. The evaluated were Withania somnifera, Warbugia ugandensis, Aloe secundiflora, while COX-2, CASP9, Bcl-xL, Bcl2 5-LOX CRC cell lines (Caco-2). To establish critical gaps this important topic, well-thought systematic reviews conducted at initial stage study. Plant extracts obtained using serial exhaustive extraction three different solvents (Hexane, Ethyl acetate, Methanol). Our unique study reports these as efficient natural inhibitors growth, by directly linking phytoconstituents to; downregulation 5-LOX, Bcl2, upregulation CASP9 dose-dependently. I strongly present secundiflora plant promising for carcinogenesis recommend vivo subsequent clinical trials, with substantial effects postulated. In addition, methanol ethyl acetate can extract exhibiting higher regulatory are thus highly recommended application yielding maximum benefits. Finally, suggest studies identification characterization specific plants, that involved modulatory mechanisms, resulting inhibition growth possible metastases.

Language: Английский

Citations

0
COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis (Preprint) DOI Creative Commons

Tahani Al Rahbeni,

Prakasini Satapathy, Ramaiah Itumalla

et al.

Published: Nov. 21, 2023

BACKGROUND The unprecedented emergence of the COVID-19 pandemic necessitated development and global distribution vaccines, making understanding vaccine acceptance hesitancy crucial to overcoming barriers vaccination achieving widespread immunization. OBJECTIVE This umbrella review synthesizes findings from systematic reviews meta-analyses provide insights into perceptions on across diverse populations regions. METHODS We conducted a literature search major databases identify meta-analysis that reported hesitancy. AMSTAR-2 (A Measurement Tool Assess Systematic Reviews) criteria were used assess methodological quality included reviews. Meta-analysis was performed using STATA 17 with random effect model. data synthesis is presented in table format via narrative. RESULTS Our inclusion met by 78 published between 2021 2023. analysis revealed moderate rate 63% (95% CI 0.60%-0.67%) general population, significant heterogeneity (<i>I</i><sup>2</sup> = 97.59%). Higher rates observed among health care workers individuals chronic diseases, at 64% 0.57%-0.71%) 69% 0.61%-0.76%), respectively. However, lower noted pregnant women, 48% 0.42%-0.53%), parents consenting for their children, 61.29% 0.56%-0.67%). pooled 32% 0.25%-0.39%) population. assessment 19 high-quality, 38 moderate-quality, 15 low-quality, 6 critically low-quality meta-analyses. CONCLUSIONS presence globally, emphasizing necessity population-specific, culturally sensitive interventions clear, credible information dissemination foster acceptance. disparities accentuate need continuous research understand evolving address unique concerns needs populations, thereby aiding formulation effective inclusive strategies. CLINICALTRIAL PROSPERO CRD42023468363; https://tinyurl.com/2p9kv9cr

Language: Английский

Citations

0