Craniofacial phenotyping with fetal MRI: A feasibility study of 3D visualisation, segmentation, surface-rendered and physical models DOI Creative Commons
Jacqueline Matthew, Alena Uus,

Leah De Souza

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 30, 2023

Abstract This study explores the potential of 3D Slice-to-Volume Registration (SVR) motion-corrected fetal MRI for craniofacial assessment, traditionally used only brain analysis. In addition, we present first description an automated pipeline based on Attention UNet trained segmentation, followed by surface refinement. Results printing selected models are also presented. Qualitative analysis multiplanar volumes SVR output and segmentations outputs, assessed with computer printed models, were standardised protocols that developed evaluating image quality visibility diagnostic features. A test set 25, postnatally confirmed, Trisomy 21 cases (24-36 weeks gestational age), revealed reconstructed T2 images provided 66-100% relevant head structures in output, 20-100% 60-90% anatomical was seen baseline refined model outputs respectively. Furthermore, 12 25 cases, 48%, demonstrated good or excellent overall a further 9 36% demonstrating moderate to include facial, scalp external ears. Additional physical real-size (20-36 age) good/excellent all distinguishable features between healthy control confirmed anomalies, minor manual adjustments required before printing. Despite varying data heterogeneity, T2w reconstructions sufficient resolution subjective characterisation subtle We contributed publicly accessible online atlas head, validated accurate representation normal anatomy. Future research will focus quantitative analysis, optimizing pipeline, exploring diagnostic, counselling, educational applications assessment.

Language: Английский

Développement et croissance du front DOI
M.A.M. Taverne, Roman Hossein Khonsari

Annales de Chirurgie Plastique Esthétique, Journal Year: 2024, Volume and Issue: 69(6), P. 489 - 495

Published: Nov. 1, 2024

Language: Английский

Citations

0
Craniofacial Effects of Zoledronic Acid on the Osteogenesis Imperfecta Mouse (−/−) Model of Severe Osteogenesis Imperfecta DOI Creative Commons

Gaspard Jeannerod,

Antoine Chretien,

Grégoire André

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2692 - 2692

Published: Nov. 25, 2024

Background: Osteogenesis imperfecta (OI) is a rare genetic disorder affecting mainly type I collagen, which leads to bone fragility and deformities. OI patients also present craniofacial abnormalities such as macrocephaly malocclusion. Recently, dysmorphism was highlighted in the osteogenesis mouse (oim), validated model of most severe form OI. This study explores impact zoledronic acid (ZA), commonly administered increase mass mechanical strength, on oim structure. Methods: Fifteen received single intravenous ZA injection (100 µg/kg) at 5 weeks (ZA group), while fifteen remained untreated (control). Before euthanasia 14 weeks, vivo computed tomography provided craniometric data. Post-euthanasia, heads underwent peripheral Quantitative Computed Tomography (pQCT); coronal decalcified sections through temporomandibular joints were analyzed (n = 6/mouse) after Masson’s trichrome staining (3 sections) or under polarized light collagen birefringence sections). Results: In craniometry positive effect vertical growth models compared ones, with significant increases mandibular length incisor height without any change transversal dimensions. The pQCT scans showed significantly higher total mineral density cortical ramus than group. Via microscopic analysis, cranial vault thicker group group, but differences not significant. Conclusion: To conclude, had some beneficial effects and, lower extent, thickness, dimensions did seem be influenced by intake. These data emphasize need consider whole skeleton when treating patients.

Language: Английский

Citations

0
Pediatric Craniofacial Tumor Reconstruction DOI
Matthew J. Parham, Yang Ding,

Daniel S. Wang

et al.

Seminars in Plastic Surgery, Journal Year: 2023, Volume and Issue: 37(04), P. 265 - 274

Published: Nov. 1, 2023

Abstract Effective management of pediatric craniofacial tumors requires coordinated input from medical, oncologic, and surgical specialties. Reconstructive algorithms must consider limitations in donor tissue account for future growth development. Immediate reconstruction is often focused on filling dead space, protecting underlying structures, ensuring skeletal symmetry. Staged occurs after the patient has reached maturity restoring permanent dentition. options vary depending location, size, composition resected tissue. Virtual planning (VSP) reduces complexity ensures more predictable outcomes.

Language: Английский

Citations

0
Craniofacial phenotyping with fetal MRI: A feasibility study of 3D visualisation, segmentation, surface-rendered and physical models DOI Creative Commons
Jacqueline Matthew, Alena Uus,

Leah De Souza

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 30, 2023

Abstract This study explores the potential of 3D Slice-to-Volume Registration (SVR) motion-corrected fetal MRI for craniofacial assessment, traditionally used only brain analysis. In addition, we present first description an automated pipeline based on Attention UNet trained segmentation, followed by surface refinement. Results printing selected models are also presented. Qualitative analysis multiplanar volumes SVR output and segmentations outputs, assessed with computer printed models, were standardised protocols that developed evaluating image quality visibility diagnostic features. A test set 25, postnatally confirmed, Trisomy 21 cases (24-36 weeks gestational age), revealed reconstructed T2 images provided 66-100% relevant head structures in output, 20-100% 60-90% anatomical was seen baseline refined model outputs respectively. Furthermore, 12 25 cases, 48%, demonstrated good or excellent overall a further 9 36% demonstrating moderate to include facial, scalp external ears. Additional physical real-size (20-36 age) good/excellent all distinguishable features between healthy control confirmed anomalies, minor manual adjustments required before printing. Despite varying data heterogeneity, T2w reconstructions sufficient resolution subjective characterisation subtle We contributed publicly accessible online atlas head, validated accurate representation normal anatomy. Future research will focus quantitative analysis, optimizing pipeline, exploring diagnostic, counselling, educational applications assessment.

Language: Английский

Citations

0