Mechanisms of increasing multidrug resistance in Staphylococcus hominis isolated from clinical materials DOI Creative Commons
Magdalena Szemraj, Paulina Glajzner,

Kamila Olszowiec

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Abstract The treatment of infections caused by Staphylococcus hominis remains a challenge, mainly due to the increasing resistance these bacteria antibiotics. aim study was determine antibiotic in 62 strains S. isolated from clinical materials, and identify molecular basis Forty-six were both methicillin-resistant harbored mecA gene. Twenty-three had mec complex A ccr AB1. Such combination mec complexes does not correspond any cassettes that have been demonstrated so far. However, over 80% tested multidrug-resistant, which as many 12 resistant at least seven More than half tetK, acc(6’)-Ie aph(2”), ant(4’)-I genes. erm(C) most common gene antibiotics MLS group. Two five genes groups (erm(C), msr(A), msr(B), mph(C), lnu(A)). presence vga encoding streptogramins detected one strain. All sensitive vancomycin. 11 them reduced sensitivity this eight characterized heterogeneous profile antibiotic. Our results clearly shows threat their multi-resistance. Moreover, can constitute reservoir for more pathogenic bacteria.

Language: Английский

The prevalence of multidrug resistance in Staphylococcus hominis isolated from clinical materials DOI Creative Commons
Magdalena Szemraj, Paulina Glajzner,

Kamila Olszowiec

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

The treatment of infections caused by Staphylococcus hominis remains a challenge, mainly due to the increasing resistance these bacteria antibiotics. aim study was determine antibiotic in 62 strains S. isolated from clinical materials, and identify molecular basis Forty-six were both methicillin-resistant harbored mecA gene. Twenty-three had mec complex A ccr AB1. Such combination complexes does not correspond any cassettes that have been demonstrated so far. However, over 80% tested multidrug-resistant, which as many 12 resistant at least seven More than half tetK, acc(6')-Ie aph(2''), ant(4')-I genes. erm(C) most common gene antibiotics MLS group. Two five genes groups (erm(C), msr(A), msr(B), mph(C), lnu(A)). presence vga encoding streptogramins detected one strain. All sensitive vancomycin. 11 them reduced sensitivity this eight characterized heterogeneous profile antibiotic. Our results clearly shows threat their multi-resistance. Moreover, can constitute reservoir for more pathogenic bacteria.

Language: Английский

Citations

1
Phage susceptibility determinants of the opportunistic pathogen Staphylococcus epidermidis DOI Creative Commons
Christian Beck, Janes Krusche, Ahmed M. A. Elsherbini

et al.

Current Opinion in Microbiology, Journal Year: 2024, Volume and Issue: 78, P. 102434 - 102434

Published: Feb. 16, 2024

Staphylococcus epidermidis is a common member of the human skin and nose microbiomes frequent cause invasive infections. Transducing phages accomplish horizontal transfer resistance virulence genes by mispackaging mobile-genetic elements, contributing to severe, therapy-refractory S. Lytic on other hand can be interesting candidates for new anti-S. phage therapies. Despite importance phages, we are only beginning unravel interactions. Recent studies shed light diversity, host range, receptor specificities. Modulation cell wall teichoic acids, major structures, along with defense mechanisms, crucial determinants susceptibility different groups.

Language: Английский

Citations

2
Mechanisms of increasing multidrug resistance in Staphylococcus hominis isolated from clinical materials DOI Creative Commons
Magdalena Szemraj, Paulina Glajzner,

Kamila Olszowiec

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Abstract The treatment of infections caused by Staphylococcus hominis remains a challenge, mainly due to the increasing resistance these bacteria antibiotics. aim study was determine antibiotic in 62 strains S. isolated from clinical materials, and identify molecular basis Forty-six were both methicillin-resistant harbored mecA gene. Twenty-three had mec complex A ccr AB1. Such combination mec complexes does not correspond any cassettes that have been demonstrated so far. However, over 80% tested multidrug-resistant, which as many 12 resistant at least seven More than half tetK, acc(6’)-Ie aph(2”), ant(4’)-I genes. erm(C) most common gene antibiotics MLS group. Two five genes groups (erm(C), msr(A), msr(B), mph(C), lnu(A)). presence vga encoding streptogramins detected one strain. All sensitive vancomycin. 11 them reduced sensitivity this eight characterized heterogeneous profile antibiotic. Our results clearly shows threat their multi-resistance. Moreover, can constitute reservoir for more pathogenic bacteria.

Language: Английский

Citations

0