Mechanisms underlying exercise intolerance in Long COVID: an accumulation of multi-system dysfunction DOI Creative Commons

Alexandra Jamieson,

Lamia Al Saikhan,

Lamis Alghamdi

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 9, 2023

Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus (’Long COVID’) is not fully understood. Cases were recruited from a Long COVID clinic (N=32; 44±12y; 10(31%)men), age/sex- matched healthy controls (HC) (N=19; 40±13y; 6(32%)men) University College London staff students. We assessed performance, lung cardiac function, vascular health, skeletal muscle oxidative capacity autonomic nervous system (ANS) function. Key outcome measures for each physiological compared between groups using potential means(95% confidence intervals) adjusted confounders. participant outcomes to normative values. When HC, cases exhibited reduced Oxygen Uptake Efficiency Slope (1847(1679,2016) vs (2176(1978,2373) ml/min, p=0.002) Anaerobic Threshold (13.2(12.2,14.3) 15.6(14.4,17.2) ml/Kg/min, p<0.001), lower on near infrared spectroscopy (τ: 38.7(31.9,45.6) 24.6(19.1,30.1) seconds, p=0.001). In cases, ANS fell below normal limits in 39%. associated performance absence evidence microvascular dysfunction, suggesting mitochondrial pathology. There was attendant dysregulation significant proportion. These multi-system factors might contribute impaired tolerance sufferers. Points show that line previous work. we observed also proportion cases.

Language: Английский

Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play DOI Open Access
Patrick Chambers

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role Candida explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens, suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Language: Английский

Citations

0
Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play DOI Open Access
Patrick Chambers

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role Candida explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens, suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Language: Английский

Citations

0
Indicators of heart rate variability in children with acute bronchopulmonary diseases DOI Creative Commons
O.H. Buriak,

Yu.M. Nechytailo

Modern pediatrics Ukraine, Journal Year: 2024, Volume and Issue: 3(139), P. 27 - 31

Published: April 28, 2024

Holter electrocardiogram (ECG) monitoring is a modern method for diagnosing of the cardiovascular system state and allows deeper study risks comorbidity on its part in respiratory diseases. Among significant number indicators method, heart rate variability stands out as marker balance between activity sympathetic parasympathetic parts autonomic nervous system. In children with acute diseases, it important poorly studied assessment degree influence this pathology functions heart. Aim - to analyze features rhythm relationship innervation Materials methods. 50 (18 bronchitis, 12 pneumonia 20 clinically healthy individuals control group) were examined. The functional was determined using office blood pressure measurement ECG monitoring. recorded 5 minutes, followed by an variability. Results. paper analyzes variability, which have clear physiological basis, such measure central tendency RR interval, variance, concentration, level effects rhythm. A difference data obtained experimental groups relative group established, shift towards tone revealed, bronchitis these changes are greater than patients pneumonia. Conclusions. Assessment short recording disorders. most sensitive spectral research carried accordance principles Helsinki Declaration. protocol approved Local Ethics Committee participating institution. informed consent patient conducting studies. No conflict interests declared authors.

Language: Английский

Citations

0
Mechanisms underlying exercise intolerance in Long COVID: an accumulation of multi-system dysfunction DOI Creative Commons

Alexandra Jamieson,

Lamia Al Saikhan,

Lamis Alghamdi

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 9, 2023

Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS-CoV-2 virus (’Long COVID’) is not fully understood. Cases were recruited from a Long COVID clinic (N=32; 44±12y; 10(31%)men), age/sex- matched healthy controls (HC) (N=19; 40±13y; 6(32%)men) University College London staff students. We assessed performance, lung cardiac function, vascular health, skeletal muscle oxidative capacity autonomic nervous system (ANS) function. Key outcome measures for each physiological compared between groups using potential means(95% confidence intervals) adjusted confounders. participant outcomes to normative values. When HC, cases exhibited reduced Oxygen Uptake Efficiency Slope (1847(1679,2016) vs (2176(1978,2373) ml/min, p=0.002) Anaerobic Threshold (13.2(12.2,14.3) 15.6(14.4,17.2) ml/Kg/min, p<0.001), lower on near infrared spectroscopy (τ: 38.7(31.9,45.6) 24.6(19.1,30.1) seconds, p=0.001). In cases, ANS fell below normal limits in 39%. associated performance absence evidence microvascular dysfunction, suggesting mitochondrial pathology. There was attendant dysregulation significant proportion. These multi-system factors might contribute impaired tolerance sufferers. Points show that line previous work. we observed also proportion cases.

Language: Английский

Citations

1