Sex-Specific Trends in the Prevalence of Osteoarthritis and Rheumatoid Arthritis From 2005 to 2021 in South Korea: Nationwide Cross-Sectional Study (Preprint)

Published: Feb. 14, 2024

Osteoarthritis and rheumatoid arthritis (RA) are prevalent chronic joint disorders, with prevalence rates varying by sex. However, few studies have comprehensively documented the factors contributing to sex-specific of osteoarthritis RA, including sociological impact COVID-19 pandemic. This study aims identify long-term trends in RA from 2005 2021 while examining that serve as vulnerabilities specific each sex within context Data were collected a nationally representative sample 110,225 individuals through Korea National Health Nutrition Examination Survey 2021. The included patients aged 19 years older diagnosed or South Korea. analyzed using weighted accurately represent population, 95% CI. Weighted logistic regression models used vulnerable groups at risk during pandemic assess trends. In total, (n=48,410, 43.92% male participants) 2021, remaining stable over time higher female than participants. Notably, pandemic, participants 60 exhibited was 4.92 times greater 6.44 (osteoarthritis: ratio [PR] 69.78, CI 41.66-116.88; RA: PR 17.27, 8.75-34.07). terms osteoarthritis, did not show significant association BMI (PR 1.40, 1.21-1.61; <i>P</i>=.47), whereas significantly vulnerability obese group 1.68, 1.55-1.83; <i>P</i>&lt;.001). Regarding lower education levels associated increased vulnerability, showing (male participants: 2.29, 1.61-3.27 1.50, 1.23-1.84). reveals women men. Understanding these identifying can enhance preventive efforts patient care.

Language: Английский

Epidemiology and pathogenesis of osteoarthritis

Journal of Korean Medical Association, Journal Year: 2024, Volume and Issue: 67(10), P. 620 - 628

Published: Oct. 10, 2024

Background: Osteoarthritis (OA) is the most common form of arthritis and poses a considerable socioeconomic burden, contributing to disability decreased quality life, particularly in older adults. However, current treatment for OA limited pain relief, it necessary develop disease-modifying drugs that target specific molecular mechanisms its pathogenesis.Current Concepts: The prevalence increases with age, incidence being higher individuals aged over 60 years. Furthermore, women are more likely knee hand OA, whereas hip men. global burden increasing, driven by an aging population increasing obesity. main pathological feature degradation cartilage extracellular matrix catabolic proteases such as metalloproteinase 13 (MMP13) disintegrin thrombospondin motifs 5 (Adamts5), which regulated various signaling pathways transcription factors. metabolic shift towards glycolysis, associated mitochondrial dysfunction, oxidative stress, ultimately leading chondrocyte senescence apoptosis. Chondrocytes superficial zone have stem cell-like properties secrete anabolic proteins lubricin fibulin-3. Subchondral bone remodeling emerged critical progression.Discussion Conclusion: understanding has markedly evolved recent years, shifting from traditional view “wear tear” disease multifaceted condition complex pathogenesis. This paradigm could contribute development novel strategies halt progression.

Language: Английский