Perceptions of prevalence and management of post-acute sequelae of SARS-CoV-2 (PASC) infection among healthcare workers in Kweneng District, Botswana: Report of a district-wide survey DOI Creative Commons
Tebogo T. Mamalelala, Savannah Karmen-Tuohy,

Lettie Chimbwete

et al.

PLOS Global Public Health, Journal Year: 2024, Volume and Issue: 4(11), P. e0003865 - e0003865

Published: Nov. 27, 2024

Over 9.5 million confirmed cases of COVID-19 infection have been recorded in Africa. The syndrome post-acute sequelae SARS-CoV-2 (PASC) affects an estimated 32% to 87% COVID patients globally. Data regarding prevalence and impact PASC Botswana are limited. This study used a cross-sectional survey design query healthcare workers Kweneng District, about perceived prevalence, duration, symptoms, impact, management strategies. was disseminated participants via pre-existing WhatsApp groups paper copy. Descriptive statistics were analyse quantitative data, including demographic data. 72 respondents consented completed the survey, from 650 staff meeting eligibility criteria; 63% female 36% male. majority (90%) nurses, with doctors “other” accounting for 6% 4% respondents, respectively; no administrators responded. half (72%) worked at primary care facilities 28% hospitals. Nearly all (93%) indicated seeing on weekly basis, though (61%) identified these as comprising <10% total patients. most frequently reported symptom persistent cough (64%), followed by shortness breath (54%) fatigue (49%). A substantial minority unsure how manage common 29% indicating uncertainty fatigue, respectively. Findings indicate that symptoms encountered clinical practice significant overlap acute COVID-19, influenza-like illnesses, tuberculosis, likely placing increased burden existing health system processes. Providers managing presumed PASC, current patterns may contribute unintended adverse effects. Clear algorithms screening, diagnosis, should be developed mitigate effects improve quality life survivors.

Language: Английский

Long COVID: a clinical update DOI
Trisha Greenhalgh, Manoj Sivan,

Alice Perlowski

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 404(10453), P. 707 - 724

Published: July 31, 2024

Language: Английский

Citations

88
Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches DOI Creative Commons
Tihamér Molnár,

Andrea Lehoczki,

Mónika Fekete

et al.

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 5267 - 5286

Published: April 26, 2024

Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced medical community to phenomenon of long COVID, a condition characterized persistent symptoms following resolution acute phase infection. Among myriad reported COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond initial viral pathology. Emerging evidence pointed mitochondrial dysfunction as potential underpinning mechanism contributing persistence diversity symptoms. This review aims synthesize current findings related in exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic endothelial dysfunction. Through comprehensive analysis literature, we highlight significance health pathophysiology drawing parallels with similar clinical syndromes linked post-infectious states other diseases where impairment been implicated. We discuss therapeutic strategies targeting function, including pharmacological interventions, lifestyle modifications, exercise, dietary approaches, emphasize need further research collaborative efforts advance our understanding management COVID. underscores critical role calls multidisciplinary approach address gaps knowledge treatment options those affected this condition.

Language: Английский

Citations

30
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health DOI Creative Commons
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase infection, affecting approximately 10% to over 30% those infected. It presents a significant clinical challenge, notably due pronounced neurocognitive such brain fog. The mechanisms underlying these effects are multifactorial, with mounting evidence pointing central role cerebromicrovascular dysfunction. This review investigates key pathophysiological contributing cerebrovascular dysfunction in long and their impacts on health. We discuss how endothelial tropism direct vascular trigger dysfunction, impaired neurovascular coupling, blood–brain barrier disruption, resulting compromised cerebral perfusion. Furthermore, appears induce mitochondrial enhancing oxidative stress inflammation within cells. Autoantibody formation following also potentially exacerbates injury, chronic ongoing compromise. These factors collectively contribute emergence white matter hyperintensities, promote amyloid pathology, may accelerate neurodegenerative processes, including Alzheimer’s disease. emphasizes critical advanced imaging techniques assessing health need for targeted interventions address complications. A deeper understanding essential advance treatments mitigate its long-term consequences.

Language: Английский

Citations

2
Long COVID’s Impact on Patients, Workers, & Society: A review DOI Creative Commons
Kevin T. Kavanagh,

Lindsay E. Cormier,

Christine Pontus

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(12), P. e37502 - e37502

Published: March 22, 2024

The incidence of long COVID in adult survivors an acute SARS-CoV-2 infection is approximately 11%. Of those afflicted, 26% have difficulty with day-to-day activities. majority COIVD cases occur after mild or asymptomatic infection. Children can spread infections and also develop long-term neurological, endocrine (type I diabetes), immunological sequelae. Immunological hypofunction exemplified by the recent large outbreaks respiratory syncytial virus streptococcal infections. Neurological manifestations are associated anatomical brain damage demonstrated on scans autopsy studies. prefrontal cortex particularly susceptible. Common symptoms include fog, memory loss, executive dysfunction, personality changes. impact society has been profound. Fewer than half previously employed adults who working full-time, 42% patients reported food insecurity 20% difficulties paying rent. Vaccination not only helps prevent severe COVID-19, but numerous studies found beneficial effects preventing mitigating COVID. There evidence that vaccination lessen Physical occupational therapy help regain function, approach must be "low slow." Too much physical mental activity result post-exertional malaise set back recovery process days weeks. complexity presentations coupled rampant organized disinformation, caused significant segments public to ignore sound health advice. Further research needed regarding treatment effective communication.

Language: Английский

Citations

8
Post-COVID-19 conditions and health effects in Africa: a scoping review DOI Creative Commons
Edward Wilson Ansah, Promise Kwame Salu,

Martin Sumani Daanko

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(1), P. e088983 - e088983

Published: Jan. 1, 2025

Introduction The SARS-CoV-2 pandemic has caused global devastations in social, economic and health systems of every nation, but disproportionately nations Africa. In addition to its grave effects on the systems, there is continuation or development new symptoms among individuals who have contracted virus, with potential further stress continent. Therefore, aim this scoping review was collate summarise existing research evidence prevalence post–COVID-19 conditions Methods analysis Five main databases were thoroughly searched from 1 September 2023 10 May 2024 for eligible articles based pre-established inclusion exclusion criteria. These included PubMed, Central, Scopus, Dimensions AI JSTOR. A total 17 papers review. protocol already published BMJ Open; doi:10.1136/bmjopen-2023-082519. Results Africa ranged 2% as high 94.7%. Fatigue, dyspnoea brain fog commonly reported conditions. Reduced functional status well physical psychosocial disorders by studies reviewed, no study yet Conclusions There an African setting. However, limited patients Ethics dissemination This involved secondary data; therefore, ethical approval needed. Dissemination result being done through international journals may also be presented at available conferences.

Language: Английский

Citations

0
The prolonged health sequelae “of the COVID-19 pandemic” in sub-Saharan Africa: a systematic review and meta-analysis DOI Creative Commons
Melsew Setegn Alie, Getayeneh Antehunegn Tesema, Gossa Fetene Abebe

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 24, 2025

Background Survivors of coronavirus disease 2019 (COVID-19) often face persistent and significant challenges that affect their physical, mental, financial wellbeing, which can significantly diminish overall quality life. The emergence new symptoms or the persistence existing ones after a severe acute respiratory syndrome 2 (SARS-CoV-2) diagnosis has given rise to complex clinical issue known as “long COVID-19” (LC). This situation placed additional strain on global healthcare systems, underscoring urgent need for ongoing management these patients. While numerous studies have been conducted long-term effects COVID-19, our systematic review, meta-analysis, is first its kind in sub-Saharan Africa, providing comprehensive understanding region highlighting necessity continuous management. Objective study aimed systematically synthesize evidence sequelae COVID-19 predictors Africa. Methods A thorough search was across multiple databases, including PubMed/MEDLINE, Web Science, Google/Google Scholar, African online journals, selected reference lists, from inception databases until January 12, 2024. meta-analysis proportions using random-effects restricted maximum-likelihood model. association between various factors also analyzed determine pooled influence long outcomes. Results Our analysis 16 research articles, involving total 18,104 participants revealed prevalence at 42.1% (95% CI: 29.9–55.4). health identified this review included pulmonary (27.5%), sleep disturbance (22.5%), brain fog (27.4%), fatigue (17.4%), anxiety (22.3%), chest pain (13.2%). We found observed comorbidities [POR = 4.34 1.28–14.72)], influencing Conclusion long-lasting organ even person recovered infection. These include fog, symptoms, disturbances, anxiety, fatigue, other neurological, psychiatric, respiratory, cardiovascular, general symptoms. It crucial individuals who receive careful follow-up care assess reduce any potential damage maintain Systematic registration Clinicaltrial.gov , identifier CRD42024501158.

Language: Английский

Citations

0
SPACO+: a mixed methods protocol to assessing the effectiveness of an educative intervention in patients with Long Covid DOI Creative Commons

Odette Linda Kamdem,

Caroline Dupré,

Valdez Heugno

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 29, 2025

Language: Английский

Citations

0
New-onset obstructive airway disease following COVID-19: a multicenter retrospective cohort study DOI Creative Commons
Min‐Hsiang Chuang, Wei Hsu, Ya‐Wen Tsai

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 4, 2024

Language: Английский

Citations

3
Rethinking the evidence on COVID-19 in Africa DOI
Philip Bejon, Ambrose Agweyu, Lynette Isabella Ochola‐Oyier

et al.

The Lancet Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Long COVID as a multisystem problem and recent challenges DOI Open Access
Oksana Mykolaivna Chemych,

K. Nehreba,

A. Yemchura

et al.

Likarska sprava, Journal Year: 2025, Volume and Issue: 1

Published: March 31, 2025

Abstract. The aim of the review is to identify and summarize main theories Long COVID, pathogenesis clinical signs. Materials Methods. 110 articles from PubMed, Scopus, Google Scholar, as well WHO data statistics on prevalence COVID for period 2022-2025, which contain relevant information this syndrome, were processed. Special attention paid lesions nervous system psycho-emotional sphere. Conclusions. 1. More than 65 million people are affected by COVID. High susceptibility observed in women, unvaccinated people, patients with chronic diseases. 2. hypotheses development inflammation due a cytokine storm, immune response production antibodies against SARS-CoV-2 proteins, nucleoprotein N spike S, vascular dysfunction increased blood-brain barrier permeability. 3. pathogenetic mechanism post-COVID syndrome persistence virus, dysregulation system, mitochondrial dysfunction, prothrombotic autoantibodies, contributes hypercoagulability. Lesions associated impaired neurotransmission, inflammation, cerebral hypoxia, formation “string vessels,” leads cognitive impairment. 4. leading symptoms damage are: “brain fog,” confusion, prolonged headache, fatigue, autonomic disorders, orthostatic insufficiency, peripheral form neuropathies, myopathies, isolated cranial nerve (anosmia agevia). 5. Depression, anxiety post-traumatic stress disorder, circadian rhythm sleep disorders signs impact sphere psychiatric disorders.

Language: Английский

Citations

0