Dietary Supplements and the Gut–Brain Axis: A Focus on Lemon, Glycerin, and Their Combinations DOI Creative Commons
Tai L. Guo,

J. Martín Navarro,

Manuel Ismael Laurencio Luna

et al.

Dietetics, Journal Year: 2024, Volume and Issue: 3(4), P. 463 - 482

Published: Nov. 1, 2024

Dietary supplements are products taken orally, and they contain an ingredient intended to augment the diet. Many studies demonstrate clear alterations in microbe abundances production of microbiota-derived metabolites, such as short-chain fatty acids, following dietary changes. This review comprehensively explores possible interactions among gut microbiota, lemon extracts, glycerin, their mixture products. Lemon extracts/components associated with a vast array health benefits, including anti-inflammation, antioxidant, anti-atherosclerotic, anti-diabetic effects. They also increased memory decreased depression. Glycerin can reduce serum free acids mimic caloric restriction; its metabolites function broad-spectrum antimicrobial. Additionally, glycerin has dehydrating effect on central nervous system focal cerebral edema improve performance by expanding plasma volume. However, it may have side effects, hyperglycemia. Therefore, combined consumption extracts may, part, mitigate each other’s effects while exerting benefits. There is growing evidence that both components metabolized microbiota modulate intestinal microbiome composition. explored important mechanism gut–brain axis regulating various these application noncommunicable neurological disorders.

Language: Английский

Capsule DenseNet++: Enhanced autism detection framework with deep learning and reinforcement learning-based lifestyle recommendation DOI
Ahmed I. Alutaibi, Sunil Kumar Sharma, Ahmad Raza Khan

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 190, P. 110038 - 110038

Published: March 21, 2025

Language: Английский

Citations

1
Study of gut microbiota in the context of neurological disorders DOI
Radka Roubalová, Petra Procházková

Neurologie pro praxi, Journal Year: 2025, Volume and Issue: 26(1), P. 61 - 66

Published: March 19, 2025

Language: Английский

Citations

0
The Effect of Gut Microbiome, Neurotransmitters, and Digital Insights in Autism DOI Creative Commons
Victoria Bamicha, Pantelis Pergantis, Athanasios Drigas

et al.

Applied Microbiology, Journal Year: 2024, Volume and Issue: 4(4), P. 1677 - 1701

Published: Dec. 16, 2024

Background: Autism spectrum disorder is a multifactorial phenomenon whose genetic, biological, environmental, and nutritional factors outline the heterogeneous phenotype of disease. A limitation in social connections with others, stereotyped reactions, specific interests preferences characterize behavioral manifestations person autism. Also, weaknesses are found emotional, cognitive, metacognitive development, significantly burdening individual’s quality life. Lately, it has gained widespread acceptance that gut microbiome neurotransmission constitute two decisive etiological autism both prenatal period postnatally. This study aims to investigate data on interaction between quantitative qualitative composition flora humans, as well their influences appearance progression symptoms disorder. At same time, captures role digital technology diagnosing intervening autism, which mainly related individual subjects under study. Methods: The current research employs an exploratory review provide concise overview complex neuronal functions associated neurotransmitter action homeostasis mechanisms allow brain human body survive perform optimally. Results: 111 sources highlighted connection dietary habits synthesizing releasing neurotransmitters influence emergence autism-related behaviors. Conclusions: literature review’s findings revealed importance performance behavioral, social, cognitive development among individuals Moreover, noteworthy combining healthy lifestyle targeted use tools can improve intensity symptoms.

Language: Английский

Citations

4
A Machine-Learning Approach to Finding Gene Target Treatment Options for Long COVID DOI Creative Commons
Alejandro Lopez‐Rincon

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Abstract Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), encompasses a range symptoms persisting for weeks or months after the acute phase COVID-19. These symptoms, affecting multiple organ systems, significantly impact quality life. This study employs machine-learning approach to identify gene targets treating COVID. Using datasets GSE275334, GSE270045, and GSE157103, Recursive Ensemble Feature Selection (REFS) was applied key genes associated with The highlights therapeutic potential targeting such PPP2CB, SOCS3, ARG1, IL6R, ECHS1. Clinical trials pharmacological interventions, including dual antiplatelet therapy anticoagulants, are explored their efficacy in managing COVID-19-related complications. findings suggest that machine learning can effectively biomarkers targets, offering promising avenue personalized treatment strategies COVID patients.

Language: Английский

Citations

0
Gut Microbiome Pilot Study of Patients With CHARGE Syndrome and Sibling Controls DOI Creative Commons
Emily R. Chedrawe,

Jessica Connors,

Angela Arra

et al.

American Journal of Medical Genetics Part A, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Difficulties with feeding and digestion are common in individuals CHARGE syndrome. Animal models CHD7 gene variants demonstrate abnormal gut innovation dysmotility. Our pilot study evaluated whether syndrome have differences their microbiome compared to unaffected siblings. Participants between the ages of 2-18 were recruited from Atlantic Canada a confirmed genetic diagnosis Gut Microbiome DNA analysis was performed on stool samples using 16S ribosomal RNA (rRNA) sequences. The PASSFP PEDSQL served as GI symptom questionnaires. Eleven participants completed this one twin pair (CHARGE = 7, sibling controls 4). mean percent abundance for four most phyla versus Controls showed trend towards increased Bacteroidetes, Proteobacteria, decrease Firmicutes Actinobacteria but not significant. comparisons based (< 77) normal ( ≥$$ \ge $$ scores, found significantly elevated Bacteroidetes (p 0.042, 59.5% ± 15.1% vs. 33.1% 14.6%) decreased 37.5% 15.9% 62.4% 14.0%) scores. Alpha diversity did differ either disease or data that, although there changes siblings, change appears be related severity symptoms necessarily itself, more pronounced difficulties symptoms.

Language: Английский

Citations

0
Advances on Natural Development Behavior Intervention in Children with Autism in Foreign Countries DOI

茹 陈

Advances in Psychology, Journal Year: 2025, Volume and Issue: 15(04), P. 144 - 152

Published: Jan. 1, 2025

Language: Английский

Citations

0
Contributions of Artificial Intelligence to Analysis of Gut Microbiota in Autism Spectrum Disorder: A Systematic Review DOI Creative Commons
Pau Climent-Pérez, Agustín Ernesto Martínez‐González, Pedro Andreo‐Martínez

et al.

Children, Journal Year: 2024, Volume and Issue: 11(8), P. 931 - 931

Published: July 31, 2024

Background: Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental whose etiology not known today, but everything indicates that it multifactorial. For example, genetic and epigenetic factors seem to be involved in the of ASD. In recent years, there has been an increase studies on implications gut microbiota (GM) behavior children with ASD given dysbiosis GM may trigger onset, development progression through microbiota–gut–brain axis. At same time, significant progress occurred artificial intelligence (AI). Methods: The aim present study was perform systematic review articles using AI analyze individuals line PRISMA model, 12 were selected. Results: Outcomes reveal majority relevant this topic have conducted China (33.3%) Italy (25%), followed by Netherlands (16.6%), Mexico (16.6%) South Korea (8.3%). Conclusions: bacteria Bifidobacterium most biomarker regard Although provides very promising approach data analysis, caution needed avoid over-interpretation preliminary findings. A first step must taken representative general population samples order obtain standard according age, sex country. Thus, more work required bridge gap between mental health research clinical care

Language: Английский

Citations

3
Analysis of Gut Bacterial and Fungal Microbiota in Children with Autism Spectrum Disorder and Their Non-Autistic Siblings DOI Open Access

Mauricio Retuerto,

Hilmi Al-Shakhshir,

Janet Herrada

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 3004 - 3004

Published: Sept. 5, 2024

Autism Spectrum Disorder (ASD) is a multifactorial disorder involving genetic and environmental factors leading to pathophysiologic symptoms comorbidities including neurodevelopmental disorders, anxiety, immune dysregulation, gastrointestinal (GI) abnormalities. Abnormal intestinal permeability has been reported among ASD patients it well established that disturbances in eating patterns may cause gut microbiome imbalance (i.e., dysbiosis). Therefore, studies focusing on the potential relationship between microbiota are emerging. We compared bacteriome mycobiome of cohort subjects with their non-ASD siblings. Differences include significant decrease at phylum level Cyanobacteria (0.015% vs. 0.074%, p < 0.0003), genus Bacteroides (28.3% 36.8%, 0.03). Species-level analysis showed Faecalibacterium prausnitzii, Prevotella copri, fragilis, Akkermansia municiphila. Mycobiome an increase fungal Ascomycota (98.3% 94%, 0.047) Candida albicans (27.1% 13.2%, 0.055). Multivariate organisms from Delftia were predictive increased odds ratio ASD, whereas decreases Azospirillum associated ASD. screened 24 probiotic identify strains could alter growth identified as elevated within subject samples. In preliminary vivo preclinical test, we challenged wild-type Balb/c mice acidovorans (increased subjects) by oral gavage changes behavioral sham-treated controls. An vitro biofilm assay was used determine ability potentially beneficial microorganisms biofilm-forming acidovorans, break down fiber. Downregulation cyanobacteria (generally for inflammation wound healing) combined species such D. suggests ASD-related GI result concomitant pathogens, probiotics can be counteract these changes.

Language: Английский

Citations

3
Guild-based approach for mitigating information loss and distortion issues in microbiome analysis DOI Creative Commons
Liping Zhao, Guojun Wu, Naisi Zhao

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(17)

Published: Sept. 2, 2024

Language: Английский

Citations

2
Cutting-Edge iPSC-Based Approaches in Studying Host—Microbe Interactions in Neuropsychiatric Disorders DOI Open Access
Marija Mihailovich, Svetlana Soković Bajić, Miroslav Dinić

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10156 - 10156

Published: Sept. 21, 2024

Gut microbiota (GM), together with its metabolites (such as SCFA, tryptophan, dopamine, GABA, etc.), plays an important role in the functioning of central nervous system. Various neurological and psychiatric disorders are associated changes composition GM their metabolites, which puts them foreground a potential adjuvant therapy. However, molecular mechanisms behind this relationship not clear enough. Therefore, before considering beneficial microbes and/or therapeutics for brain disorders, underlying microbiota-host interactions must be identified characterized detail. In review, we summarize current knowledge alterations observed prevalent multiple sclerosis, major depressive disorder, Alzheimer's disease, autism spectrum experimental evidence to improve patients' quality life. We further discuss main obstacles study GM-host describe state-of-the-art solution trends field, namely "culturomics" enables culture identification novel bacteria that inhabit human gut, models gut blood-brain barrier well gut-brain axis based on induced pluripotent stem cells (iPSCs) iPSC derivatives, thus pursuing personalized medicine agenda neuropsychiatric disorders.

Language: Английский

Citations

2