Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 393 - 393

Published: March 25, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Language: Английский

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Determination of Antioxidant, Antidiabetic, Anticholinergic, Antiglaucoma Properties and Comprehensive Phytochemical Content by LC‐MS/MS of Bingöl Honeybee Pollen

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

Honeybee pollen is the most important food and protein source for bees. It a highly nutritious natural product humans due to its content. Pollen shows different phytochemical content variable biological activity according geography vegetation. Therefore, in this study, comprehensive by LC-MS/MS, antioxidant properties assays, with enzyme inhibition potential; antidiabetic, anticholinergic, antiglaucoma properties, were determined from sample Bingöl province, one of significant beekeeping centers Türkiye. As result 15 metabolites determined, highest concentration quinic acid (1.531 mg analyte/g extract) was found. Antioxidant results: total phenolic 113.14 GAE/g, flavonoid 64.11 QE/g, Fe3+ reduction 0.43 μg/mL, CUPRAC 0.511 FRAP 0.976 DPPH IC50: 1.06 ABTS 0.933 DMPD 0.598 μg/mL. In addition, showed antiglaucoma, antidiabetic inhibiting carbonic anhydrase isoenzyme II (hCA II), acetylcholinesterase (AChE), α- amylase enzymes, respectively. it that has and, first time, inhibits hCA II, AChE, α-amylase enzymes.

Language: Английский

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Assessment of essential and potentially toxic elements in beehive pro`ducts from stingless bees from the northeast of Brazil: Determination and in vitro bioaccessibility evaluation

Food Chemistry, Journal Year: 2025, Volume and Issue: 474, P. 143132 - 143132

Published: Jan. 30, 2025

Language: Английский

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Novel Phenoselenazines as Amyloid-β Aggregation Inhibitors

ACS Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

A novel library of N-benzylphenoselenazine derivatives 8a-j were designed, synthesized, and evaluated as inhibitors amyloid-beta (Aβ42) aggregation. In the thioflavin T-based fluorescence aggregation kinetics assay, compounds 8i 8j exhibited excellent inhibition Aβ42 (∼91% at 25 μM), activity was comparable to that reference agents resveratrol (∼88%) methylene blue (∼95% inhibition). Both also demonstrated disaggregation properties (58% 76% respectively μM) antioxidant (80.5% 59% μM). cell culture studies, both able reduce Aβ42-mediated cytotoxicity. Computational studies suggest these interact in a narrow channel formed by N- C-termini pentamer model stabilize assembly prevent further These results demonstrate viability N-benzylphenoselenazines promising candidates target amyloid cascade Alzheimer's disease.

Language: Английский

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Composite Dietary Antioxidant Index is negatively associated with olfactory dysfunction among adults in the United States: A cross-sectional study

Nutrition Research, Journal Year: 2024, Volume and Issue: 124, P. 85 - 93

Published: Feb. 9, 2024

Language: Английский

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Green synthesis of silver nanoparticle using pollen extract from Tetragonisca angustula a stingless bee

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 27, 2024

Abstract This study explores the green synthesis of silver nanoparticles (AgNPs) using a methanolic extract fermented pollen from Tetragonisca angustula , species stingless bees. The AgNPs exhibit spherical morphology, low charge values, and suspension stability, with their unique composition attributed to elements extract. Antioxidant assays show comparable activity between AgNPs, emphasizing retention antioxidant effects. synthesized demonstrate antimicrobial against multidrug-resistant bacteria, highlighting potential in combating bacterial resistance. no toxic effects on Drosophila melanogaster even enhance hatching rate eggs. underscores innovative use bee synthesis, offering insights into varied applications biomedicine.

Language: Английский

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The Neuroprotective and Cognitive-Enhancing Effects of <em>Bacopa monnieri</em>: A Systematic Review

Published: Feb. 5, 2024

The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM's beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-&kappa;B phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.

Language: Английский

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Phytochemical Importance of Medicinal Plants as Potential Sources Against Neurodegenerative Diseases

Published: Jan. 1, 2024

Language: Английский

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Olive Oil Industry By-Products as a Novel Source of Biophenols with a Promising Role in Alzheimer Disease Prevention

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4841 - 4841

Published: Oct. 12, 2024

This review explores the potential health benefits and applications of phenolic secoiridoids derived from olive oil by-products in prevention Alzheimer's disease (AD). As reviewed herein, polyphenols, such as epigallocatechin-3-gallate, epicatechin, resveratrol, show vitro vivo antioxidant, anti-inflammatory, neuroprotective properties, are particularly relevant context AD, a leading cause dementia globally. The industry, Mediterranean region, produces significant amounts waste, including leaves, pomace, wastewater, which pose environmental challenges but also offer an untapped source bioactive compounds. Despite promising studies indicating that olive-derived oleuropein hydroxytyrosol, may mitigate AD pathology, human clinical trials remain limited. variability extraction methods complex nature further complicate research. Future should focus on standardizing protocols conducting robust to fully assess therapeutic these approach not only supports development new treatments for promotes sustainability by valorizing industry waste.

Language: Английский

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