Study on the causality of cathepsin on autoimmune diseases and cancer: evidence from mendelian randomization analysis DOI
Xue Gao, Xinyu Zhao,

Shuhan Yang

et al.

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 317(1)

Published: Dec. 14, 2024

Language: Английский

Genetic insights into the shared molecular mechanisms of Crohn’s disease and breast cancer: a Mendelian randomization and deep learning approach DOI Creative Commons
Zhiwei Wang,

Ju Yang,

Zong Yao Zhang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 18, 2025

Language: Английский

Citations

0
An atlas on risk factors for gastrointestinal cancers: A systematic review of Mendelian randomization studies DOI
Yixuan Huang, Junhua Wu,

Yuqiang Zhao

et al.

Preventive Medicine, Journal Year: 2024, Volume and Issue: 189, P. 108147 - 108147

Published: Oct. 3, 2024

Language: Английский

Citations

3
Role of immune cells in mediating the effect of phosphatidylcholine (17:0_18:2) on liver cirrhosis DOI Creative Commons

Weiye Lin,

Ning Han, Yiqian Qu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Liver cirrhosis (LC) is the terminal stage of various chronic liver diseases, with complications decompensated being primary cause death. Recent studies have shown that lipid metabolic disorders and inflammatory responses within liver, leading to fibrosis inflammation, are associated development cirrhosis. This study investigated causal relationship between phosphatidylcholine (17:0_18:2) (PC) LC, as well mediating role immune cells. Utilizing summary data from genome-wide association (GWAS) information Finnish database, single nucleotide polymorphisms (SNPs) were selected instrumental variables (IVs) for a two-step Mendelian randomization (MR) analysis gene-predicted LC (including 1266 cases 407,801 controls). The results indicate negative genetically predicted PC levels (OR 0.819, 95% CI 0.693–0.967; P = 0.019, IVW method). Immune cells, specifically CD33 on CD33dim HLA DR- (with mediation effect ratio 7.027%) Im MDSC 5.763%), play reverse in LC. provides new perspective prevention treatment strategies involving metabolism regulation.

Language: Английский

Citations

0
Role of immune cells in mediating the effect of triacylglycerol (50:2) on hypotension DOI Creative Commons

Weiye Lin,

Ning Han,

Qianran Hong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 22, 2024

Abstract Objective To explore the causal relationship between genetically predicted triglyceride (TG) levels and risk of hypotension under mediation immune cells using a two-step Mendelian randomization (MR) approach. Methods We utilized summary data from genome-wide association studies (GWAS) information FinnGen database to select single nucleotide polymorphisms (SNPs) as instrumental variables (IVs). A MR analysis was conducted on (including 4924 cases 406223 controls), employing methods such inverse variance weighting (IVW), MR-Egger regression, sensitivity ensure accuracy robustness results. Results Genetically TG found be positively associated with (for each 1 SD increase, increased by 21.1%, OR = 1.211; 95% CI 1.085–1.352, P < 0.001, IVW method), CD25 + CD8br AC (mediation effect ratio 7.223%) IgD CD38dim %B cell 5.730%) acting mediators. The above analyses did not exhibit heterogeneity pleiotropy. Conclusion Our study provides new perspective for deeper understanding lipid metabolism pathways hypotension. This includes optimizing dietary structure improving health system prevent occurrence hypotension, or biomarkers identify individuals at potential early on, providing possibilities targeted treatment. can contribute more precise personalized strategies diagnosis, treatment, management patients Additionally, further research is needed validate our findings.

Language: Английский

Citations

0
A Systematic Review of Mendelian Randomization Studies on Celiac Disease. DOI Creative Commons
Mahmud Omar,

Reem Agbareia,

Salih Nassar

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

Abstract Background and Objective Mendelian randomization (MR) has become an important tool in epidemiology, used to infer causal relationships diseases. This review aims consolidate existing MR evidence concerning celiac disease (CeD). Methods We systematically searched major databases up May 2024, adhering PRISMA guidelines. Only studies explicitly investigating CeD were included. assessed the quality of each study based on strength, independence, exclusivity instrumental variables used. Results From initial pool 207 articles, 35 met our inclusion criteria. These frequently addressed relationship between autoimmune diseases like inflammatory bowel (IBD) explored connections with gut microbiota, various cancers, metabolic disorders. Significant findings highlight a robust bi-directional association IBD complex interactions microbiota. Notably, many associations reported near threshold clinical significance. Conclusion systematic highlights dual nature current CeD. On one hand, we observe consistent CeD, IBDs, other, there is plethora weaker that raise critical questions about their research work lays solid foundation for deeper investigations into these links, particularly relation lymphomas psychiatric conditions. It calls expanded use other methodologies explore under-researched areas.

Language: Английский

Citations

0
Type I Diabetes Mellitus impairs cytotoxic immunity through CEACAM5 upregulation in colorectal cancer DOI
Yingying Li,

Feng Xingyong,

Zhao Deying

et al.

Journal of Molecular Histology, Journal Year: 2024, Volume and Issue: 55(6), P. 1285 - 1293

Published: Oct. 18, 2024

Language: Английский

Citations

0
Immune cells mediate the causal relationship between uveitis and colorectal cancer via Mendelian randomization analysis DOI Creative Commons
Li Zhou, Jiwang Zhang

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 29, 2024

Colorectal cancer (CRC) is one of the most common and deadly malignancies worldwide, immune regulation plays a critical role in its development. This study investigates causal relationships between uveitis, specific cell traits, CRC using Mendelian Randomization (MR) analyses. A total 21 single nucleotide polymorphisms (SNPs) associated with uveitis were identified, analysis revealed that 1 log-odds increase was linked to statistically significant 3.0% reduction odds (IVW OR = 0.970, 95% CI: 0.946-0.995, P 0.021). protective effect also observed weighted median approach (OR 0.963, 0.931-0.997, 0.034), reinforcing robustness findings. Furthermore, both univariable multivariable MR analyses highlighted influence traits on odds. Notably, levels extracellular monocyte HLA-DR expression emerged as factor, an 1.084, 1.008-1.165, 0.030). The proportion mediated by expression, calculated ratio indirect estimates from analyses, approximately 34.1%(95% 10.23-58.04%). These findings underscore complex interplay carcinogenesis, offering insights into potential mechanisms underlying development suggesting avenues for targeted prevention therapeutic strategies.

Language: Английский

Citations

0
Study on the causality of cathepsin on autoimmune diseases and cancer: evidence from mendelian randomization analysis DOI
Xue Gao, Xinyu Zhao,

Shuhan Yang

et al.

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 317(1)

Published: Dec. 14, 2024

Language: Английский

Citations

0