Fatigue outcomes following COVID-19: a systematic review and meta-analysis

BMJ Open, Journal Year: 2023, Volume and Issue: 13(4), P. e063969 - e063969

Published: April 1, 2023

Objectives Fatigue is a pervasive clinical symptom in coronaviruses and may continue beyond the acute phase, lasting for several months or years. This systematic review meta-analysis aimed to incorporate current evidence postinfection fatigue among survivors of SARS-CoV-2 investigate associated factors. Methods Embase, PsyINFO, Medline, CINAHL, CDSR, Open Grey, BioRxiv MedRxiv were systematically searched from January 2019 December 2021. Eligible records included all study designs English. Outcomes vitality adults with confirmed diagnosis measured at >30 days post infection. Non-confirmed cases excluded. JBI risk bias was assessed by three reviewers. Random effects model used pooled proportion 95% CIs. A mixed meta-regression 35 prospective articles calculated change overtime. Subgroup analyses explored specific group characteristics methodology. Heterogeneity using Cochran’s Q I 2 statistic. Egger’s tests publication bias. Results Database searches returned 14 262 records. Following deduplication screening, 178 identified. 147 (n=48 466 participants) meta-analyses. Pooled prevalence 41% (95% CI: 37% 45%, k=147, =98%). significantly reduced over time (−0.057, −107 −0.008, k=35, =99.3%, p=0.05). higher found studies valid scale (51%, 43% 58%, k=36, =96.2%, p=0.004). No significant difference design (p=0.272). test indicated except scales. Quality assessments 4% low bias, 78% moderate 18% high risk. Frequently reported associations female gender, age, physical functioning, breathlessness psychological distress. Conclusion revealed that experienced following their Non-modifiable factors morbidity contribute ongoing impede recovery. PROSPERO registration number CRD42020201247.

Language: Английский

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How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes

Seminars in Arthritis and Rheumatism, Journal Year: 2024, Volume and Issue: 67, P. 152455 - 152455

Published: May 7, 2024

Language: Английский

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Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies

Revista de Neurología, Journal Year: 2025, Volume and Issue: 79(12)

Published: Jan. 24, 2025

Introduction: Long COVID is defined by National Institute for Health and Care Excellence (NICE) as the set of signs symptoms that develop during or after a SARS-CoV-2 infection continue more than twelve weeks without any alternative diagnosis. One most frequent persistent reported patients verified in neuroimaging studies cognitive dysfunction, due to generalized hypoconnectivity diffuse axonal lesion white matter. Therefore, objectives present review are determine how long functions remain affected explore which beyond three months follow-up up 65 years age previous neuropsychological psychiatric complications. Methods: A systematic was performed using PRISMA criteria 11 articles were included through comprehensive search five different databases: PubMed, Medline, Scopus, WOS ProQuest. The risk bias assessed Newcastle-Ottawa scale. Results: Cognitive problems persist over time improve slowly, although seem agree areas improved significantly one year. remained impaired longest processing speed attention. Conclusions: These alterations cause reduction quality life work capacity manifest need intervention.

Language: Английский

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Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 17, 2024

Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms risk factors underlying these alterations remain elusive. Given significant global incidence of COVID-19, identifying that can distinguish individuals at developing is crucial for prioritizing follow-up care. Here, we report findings a sample patients consisting 73 adults with mild to moderate SARS-CoV-2 infection without signs respiratory failure 27 infections attributed other agents no history COVID-19. The participants underwent screening, decision-making task, MRI evaluations. We assessed presence anosmia requirement hospitalization. Groups did not differ in age or performance. who presented exhibited more impulsive alternative changes after shift probabilities (r = − 0.26, p 0.001), while required hospitalization showed perseverative choices 0.25, 0.003). Anosmia correlated measures, including decreased functional activity during thinning cortical thickness parietal regions, loss white matter integrity. Hence, could be factor considered when at-risk populations follow-up.

Language: Английский

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Systematic Review and Meta-Analysis of Clinically Relevant Executive Functions Tests Performance after COVID-19

Behavioural Neurology, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 9

Published: Feb. 9, 2023

It is widely known that COVID-19 has a number of prolonged effects on general health, wellbeing, and cognitive functioning. However, studies using differentiated performance measures functions are still not spread making it hard to assess the exact get impaired. Taking into account similarities between post-COVID 'brain fog' chemofog, we hypothesized executive (EF) would be Literature search yielded six with 14 effect sizes interest; pooled size was small medium (d = -0.35). Combined narrative synthesis without comparison group, these results show EF impaired after COVID-19; although, in most cases impairment transient does seem severe. These specify picture may help discover its mechanisms ways helping people long COVID.

Language: Английский

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Characterization of cognitive symptoms in post COVID-19 patients

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: May 13, 2024

Abstract Cognitive symptoms (CS) belong to the most common manifestations of Post COVID-19 (PC) condition. We sought objectify CS in PC patients using routine diagnostic assessments: neurocognitive testing (NCT) and brain imaging (BI). Further, we investigated possible associations with patient reported outcomes (PROs), risk factors for developing CS. Clinical data PROs 315 were assessed at a mean 6 months after SARS-CoV-2 infection. 231 (73.3%) any sort Among them, 78 underwent NCT 55 received BI. In NCT, cognitive domains affected working memory, attention, concentration. Nonetheless, pathological thresholds exceeded only few cases. Neurocognitive performance did not differ significantly between complaining severe (n = 26) versus non-severe 52) BI findings abnormal 8 (14.5%) cases but likely related PC. Patients reporting high severity scored worse PHQ-9, FSS, WHOQOL-BREF, more report impaired sleep, had higher prevalence psychiatric diagnoses. Overall, could confirm mild impairment some all CS, while studies affect results, associated depression (PHQ-9), fatigue (FSS), reduced quality life (WHOQOL-BREF) illnesses. These support importance BI, neuro-psychological assessment work-up Trial registration number date registration: DRKS00030974, 22 Dec 2022, retrospectively registered.

Language: Английский

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Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 11, 2025

Abstract A substantial proportion of patients suffer from Post-COVID Syndrome (PCS) with fatigue and impairment memory concentration being the most important symptoms. We here set out to perform in-depth neuropsychological assessment PCS referred Neurologic clinic compared without sequelae after COVID-19 (non-PCS) healthy controls (HC) decipher prevalent cognitive deficits. included n = 60 neurologic symptoms, 15 non-PCS controls. Basic socioeconomic data subjective complaints were recorded. This was followed by a detailed test battery, including assessments general orientation, motor fatigue, screening depressive anxiety information processing speed, concentration, visuomotor attention, verbal short-term working memory, flexibility, semantic phonematic word fluency, as well visual functions. had more significantly higher scores levels symptoms Non-PCS HC. Deep showed that performed worse in deficits impaired mental flexibility an executive subfunction, reactivity (prolonged reaction time). Multiple regression affected speed; depression did not. Self-reported deficits, are mirrored performance domains memory. The present results should be considered optimize treatment algorithms for therapy rehabilitation programs

Language: Английский

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Cognitive Slowing, Dysfunction in Verbal Working Memory, Divided Attention and Response Inhibition in Post COVID-19 Condition in Young Adults

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 821 - 821

Published: May 21, 2025

After COVID-19 infection, about 30% of people have clinically persisting symptoms, characterized as Post Condition (PCC). One the most reported symptoms in PCC is cognitive dysfunction, yet there are only a few studies investigating long-term effects on different domains function. A total 107 young adults, university students aged 18–34 years, participated. In total, 68.2% had contracted SARS-CoV-2; 21.9% showed PCC. Three groups were compared: no-C19 (COVID-19-negative controls), C19 (COVID-19-recovered without PCC) and Attention executive function measured with Vienna Test System (Schuhfried®, Mödling, Austria). verbal working memory, group significantly lower performance moderate effect. The rate below-average was higher (56.2%) compared to (20.6%) (15.8%). divided attention response inhibition, also performance, 62.5% 37.5%, respectively, than C19. co-occurrence decreased functions pronounced present study revealed significant long-lasting dysfunction two years after infection. Verbal memory impaired, found inhibition. addition, an increased reaction time tasks, demonstrating slowing

Language: Английский

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Neuroinflammation in Post COVID‐19 Sequelae: Neuroinvasion and Neuroimmune Crosstalk

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(6)

Published: Nov. 1, 2024

Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in December 2019 triggered a swift global spread, leading to devastating pandemic. Alarmingly, approximately one four individuals diagnosed with disease (COVID‐19) experience varying degrees cognitive impairment, raising concerns about potential increase neurological sequelae cases. Neuroinflammation seems be the key pathophysiological hallmark linking mild COVID‐19 fatigue, and patients, highlighting interaction between nervous immune systems following SARS‐CoV‐2 infection. Several hypotheses have been proposed explain how virus disrupts physiological pathways trigger inflammation within CNS, potentially neuronal damage. These include neuroinvasion, systemic inflammation, disruption lung gut‐brain axes, reactivation latent viruses. This review explores origins neuroinflammation underlying neuroimmune cross‐talk, important unanswered questions field. Addressing these fundamental issues could enhance our understanding virus's impact on CNS inform strategies mitigate its detrimental effects.

Language: Английский

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Persistent neurocognitive deficits in long COVID: Evidence of structural changes and network abnormalities following mild infection

Cortex, Journal Year: 2025, Volume and Issue: 187, P. 98 - 110

Published: May 2, 2025

Language: Английский

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