The Roles and Molecular Mechanisms of HIF-1α in Pulpitis DOI
Linlin Shao, Qin Wang, Bolin Chen

et al.

Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Pulpitis is characterized by inflammation within dental pulp tissue, primarily triggered bacterial infection. Hypoxia-inducible factor-1α (HIF-1α), a key transcriptional regulator, stabilized under the hypoxic conditions associated with pulpitis. This review examines roles and molecular mechanisms of HIF-1α in pathogenesis progression Hypoxia pulpitis prevents degradation HIF-1α, leading to its elevated expression. Furthermore, lipopolysaccharide from invading bacteria upregulates transcription through nuclear factor kappa B mitogen-activated protein kinase pathways. regulates immunity remodeling stage-dependent manner controlling various cytokines. During stage, promotes recruitment neutrophils enhances their bactericidal effects facilitating neutrophil extracellular trap release M1 macrophage polarization. Concurrently, contributes programmed cell death increasing mitophagy. In proliferation stimulates immune responses involving T cells dendritic cells. supports angiogenesis pulp-dentin regeneration. However, excessive pulpitis-induced hypoxia may disrupt vascular dynamics chamber. disruption highlights critical threshold for beyond which might accelerate necrosis. Overall, plays central role regulating tissue during A comprehensive understanding physiological pathological essential advancement effective strategies manage irreversible

Language: Английский

The Roles and Molecular Mechanisms of HIF-1α in Pulpitis DOI
Linlin Shao, Qin Wang, Bolin Chen

et al.

Journal of Dental Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Pulpitis is characterized by inflammation within dental pulp tissue, primarily triggered bacterial infection. Hypoxia-inducible factor-1α (HIF-1α), a key transcriptional regulator, stabilized under the hypoxic conditions associated with pulpitis. This review examines roles and molecular mechanisms of HIF-1α in pathogenesis progression Hypoxia pulpitis prevents degradation HIF-1α, leading to its elevated expression. Furthermore, lipopolysaccharide from invading bacteria upregulates transcription through nuclear factor kappa B mitogen-activated protein kinase pathways. regulates immunity remodeling stage-dependent manner controlling various cytokines. During stage, promotes recruitment neutrophils enhances their bactericidal effects facilitating neutrophil extracellular trap release M1 macrophage polarization. Concurrently, contributes programmed cell death increasing mitophagy. In proliferation stimulates immune responses involving T cells dendritic cells. supports angiogenesis pulp-dentin regeneration. However, excessive pulpitis-induced hypoxia may disrupt vascular dynamics chamber. disruption highlights critical threshold for beyond which might accelerate necrosis. Overall, plays central role regulating tissue during A comprehensive understanding physiological pathological essential advancement effective strategies manage irreversible

Language: Английский

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