Modulation of inhibitory synaptic plasticity for restoration of basal ganglia dynamics in Parkinson’s disease DOI Creative Commons
Karen A. Spencer, Alexandra Boogers, Srdjan Sumarac

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 10, 2024

Abstract Introduction Parkinson’s disease is characterized, in part, by hypoactivity of both direct pathway inhibitory projections from striatum to the globus pallidus internus (GPi) and indirect externus (GPe) subthalamic nucleus (STN), giving rise disrupted basal ganglia circuit activity. In this study, we explored use intracranial stimulation for eliciting long-term potentiation (LTP) each these pathologically underactive restoration dynamics amelioration motor symptoms. Methods Data were collected a total 31 people with (42 hemispheres). During deep brain (DBS) surgery, assessed microelectrode stimulation-induced changes evoked field potentials (fEP) hand kinematics before versus after 40-second train high-frequency (HFS) GPi (n = 7, 11 sites at 100 Hz) STN 10, 14 Hz; n 4, 7 180 Hz). Additionally, beta oscillations chronic DBS implants 6 125 4 Results Intraoperatively, increases fEP amplitude (p 0.002) improved performance 0.003) observed Hz HFS GPi; while STN, did not potentiate fEPs 0.589) or improve 0.460) (similar results yielded STN). Similarly, extraoperative GPi-DBS produced suppression power (p=0.096) improvement 0.077) STN-DBS significantly affect 0.267) (p=0.850). Interpretation Our findings support that LTP-like effects may produce improvements extend beyond cessation, aligning optogenetic studies showing long-lasting recovery through periodic D1-striatal activation rodents. The lack suggests paradigms require optimization effective LTP induction. These nevertheless highlight potential LTP-based strategies sustained therapeutic benefits disease, warranting further investigation into optimizing efficacy side effect profiles.

Language: Английский

Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications DOI Creative Commons
Alfonso Enrique Martinez-Nunez, Christopher J. Rozell, Simon Little

et al.

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 25, 2025

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily the novel uses of existing technology as well next-generation technology. Our keynote speaker shared vision using neuro artificial intelligence predict depression brain electrophysiology. Innovative applications are currently being explored stroke, disorders consciousness, and sleep, while established treatments for movement like Parkinson's disease refined with adaptive stimulation. Neuromodulation is solidifying its role treating psychiatric such obsessive-compulsive disorder, particularly patients treatment-resistant symptoms. We estimate that 300,000 leads have been implanted date neurologic neuropsychiatric indications. Magnetoencephalography has provided insights into post-DBS physiological changes. field also critically examining ethical implications implants, considering long-term impacts clinicians, patients, manufacturers.

Language: Английский

Citations

0
Modulation of inhibitory synaptic plasticity for restoration of basal ganglia dynamics in Parkinson’s disease DOI Creative Commons
Karen A. Spencer, Alexandra Boogers, Srdjan Sumarac

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 10, 2024

Abstract Introduction Parkinson’s disease is characterized, in part, by hypoactivity of both direct pathway inhibitory projections from striatum to the globus pallidus internus (GPi) and indirect externus (GPe) subthalamic nucleus (STN), giving rise disrupted basal ganglia circuit activity. In this study, we explored use intracranial stimulation for eliciting long-term potentiation (LTP) each these pathologically underactive restoration dynamics amelioration motor symptoms. Methods Data were collected a total 31 people with (42 hemispheres). During deep brain (DBS) surgery, assessed microelectrode stimulation-induced changes evoked field potentials (fEP) hand kinematics before versus after 40-second train high-frequency (HFS) GPi (n = 7, 11 sites at 100 Hz) STN 10, 14 Hz; n 4, 7 180 Hz). Additionally, beta oscillations chronic DBS implants 6 125 4 Results Intraoperatively, increases fEP amplitude (p 0.002) improved performance 0.003) observed Hz HFS GPi; while STN, did not potentiate fEPs 0.589) or improve 0.460) (similar results yielded STN). Similarly, extraoperative GPi-DBS produced suppression power (p=0.096) improvement 0.077) STN-DBS significantly affect 0.267) (p=0.850). Interpretation Our findings support that LTP-like effects may produce improvements extend beyond cessation, aligning optogenetic studies showing long-lasting recovery through periodic D1-striatal activation rodents. The lack suggests paradigms require optimization effective LTP induction. These nevertheless highlight potential LTP-based strategies sustained therapeutic benefits disease, warranting further investigation into optimizing efficacy side effect profiles.

Language: Английский

Citations

0