cGAS-STING is responsible for aging of telomerase deficient zebrafish DOI Open Access

Naz Şerifoğlu,

Giulia Allavena, Bruno Lopes-Bastos

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract Telomere shortening occurs in multiple tissues throughout aging. When telomeres become critically short, they trigger DNA damage responses and p53 stabilization, leading to apoptosis or replicative senescence. In vitro , cells with short activate the cGAS-STING innate immune pathway resulting type I interferon inflammation However, consequences of these events organism are not yet understood. Here, we show that sting is responsible for premature aging telomerase-deficient zebrafish. We generated sting-/- tert-/- double mutants observed a thorough rescue phenotypes. At cellular level, lack ter t resulted reduced senescence, increased cell proliferation, low despite similar telomeres. Critically, absence function dampening response levels. zebrafish regained fertility, delayed cachexia, cancer incidence, healthspan lifespan telomerase mutants.

Language: Английский

A Review of Telomere Attrition in Cancer and Aging: Current Molecular Insights and Future Therapeutic Approaches DOI Open Access
Mina Iskandar, M. Barbéro,

Mohammed Tariq Jaber

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 257 - 257

Published: Jan. 14, 2025

As cells divide, telomeres shorten through a phenomenon known as telomere attrition, which leads to unavoidable senescence of cells. Unprotected DNA exponentially increases the odds mutations, can evolve into premature aging disorders and tumorigenesis. There has been growing academic clinical interest in exploring this duality developing optimal therapeutic strategies combat attrition cellular immortality cancer. The purpose review is provide an updated overview biology tactics address We used Rayyan platform PubMed database examined ClinicalTrial.gov registry gain insight trials their results. Cancer activate telomerase or utilize alternative lengthening escape shortening, leading near immortality. Contrarily, normal experience telomeric erosion, contributing disorders, such Werner syndrome Hutchinson-Gilford Progeria, (2) aging-related diseases, neurodegenerative cardiovascular diseases. literature presents several promising approaches potentially balance maintenance shortening This highlights gaps knowledge points potential these interventions preclinical studies inform future research cancer aging.

Language: Английский

Citations

0
Zbtb48 is a regulator of Mtfp1 expression in zebrafish DOI Creative Commons

Soon Pang Goh,

Albert Fradera-Sola, Nadine Wittkopp

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 22, 2025

Language: Английский

Citations

0
The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review DOI Creative Commons

Engelinah D. Macamo,

Zilungile L. Mkhize‐Kwitshana, Julian Mthombeni

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 7258 - 7290

Published: July 8, 2024

HIV and parasite infections accelerate biological aging, resulting in immune senescence, apoptosis cellular damage. Telomere length is considered to be one of the most effective biomarkers aging. infection have been reported shorten telomere host. This systematic review aimed highlight work that explored influence single coinfection on length. Using specific keywords related topic interest, an electronic search several online databases (Google Scholar, Web Science, Scopus, Science Direct PubMed) was conducted extract eligible articles. The association between or were assessed independently. studies mostly European countries. Of 42 research articles reviewed, independently associated with shortening. Some found no antiretroviral therapy (ART) shortening, while others ART No shortening It possible parasites may further shortening; however, this a neglected field date.

Language: Английский

Citations

1
cGAS-STING is responsible for aging of telomerase deficient zebrafish DOI Open Access

Naz Şerifoğlu,

Giulia Allavena, Bruno Lopes-Bastos

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 12, 2024

Abstract Telomere shortening occurs in multiple tissues throughout aging. When telomeres become critically short, they trigger DNA damage responses and p53 stabilization, leading to apoptosis or replicative senescence. In vitro , cells with short activate the cGAS-STING innate immune pathway resulting type I interferon inflammation However, consequences of these events organism are not yet understood. Here, we show that sting is responsible for premature aging telomerase-deficient zebrafish. We generated sting-/- tert-/- double mutants observed a thorough rescue phenotypes. At cellular level, lack ter t resulted reduced senescence, increased cell proliferation, low despite similar telomeres. Critically, absence function dampening response levels. zebrafish regained fertility, delayed cachexia, cancer incidence, healthspan lifespan telomerase mutants.

Language: Английский

Citations

0