The function and effectiveness of MSCs in preclinical models of diseases DOI
Z. Xie, Hu Zhou,

Tingting Ou

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

Mesenchymal stem cells (MSCs) have shown immense promise across diverse fields, particularly in treating various diseases. A multitude of preclinical investigations, encompassing both laboratory cellular-level studies and animal trials, demonstrated the significant effectiveness MSCs addressing a broad spectrum These collectively highlight enormous potential therapies utilizing range medical scenarios. From neurological cardiovascular disorders to autoimmune musculoskeletal disorders, including recent challenges like COVID-19, present therapeutic possibilities due their versatile capabilities. discoveries lay robust foundation for further clinical research eventual translation MSC-based treatments into mainstream practice, offering renewed optimism patients contending with complex conditions.

Language: Английский

Proteomics profiling of extracellular vesicle for identification of potential biomarkers in Alzheimer's disease: A comprehensive review DOI
Jinjin Pei, Chella Perumal Palanisamy,

Selvaraj Jayaraman

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102359 - 102359

Published: May 29, 2024

Language: Английский

Citations

8
Extracellular vesicles derived from mesenchymal stem cells alleviate depressive-like behavior in a rat model of chronic stress DOI

Zaquer Suzana Munhoz Costa-Ferro,

Rita Cunha, Erik Aranha Rossi

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 366-367, P. 123479 - 123479

Published: Feb. 20, 2025

Language: Английский

Citations

0
Mesenchymal stem cell exosome therapy: current research status in the treatment of neurodegenerative diseases and the possibility of reversing normal brain aging DOI Creative Commons

Junjie Quan,

Qing Liu,

Pinghui Li

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

With the exacerbation of aging population trend, a series neurodegenerative diseases caused by brain have become increasingly common, significantly impacting daily lives elderly and imposing heavier burdens on nations societies. Brain is complex process involving multiple mechanisms, including oxidative stress, apoptosis damaged neuronal cells, chronic inflammation, mitochondrial dysfunction, research into new therapeutic strategies to delay has gradually focus in recent years. Mesenchymal stem cells (MSCs) been widely used cell therapy due their functions such as antioxidative anti-inflammation, tissue regeneration. However, accompanying safety issues immune rejection, tumor development, pulmonary embolism cannot be avoided. Studies shown that using exosome derived from mesenchymal (MSC-Exo) for treatment safe effective method. It not only effects but also avoids risks associated with therapy. Therefore, exploring normal mechanism MSC-Exo feasible. This review summarizes characteristics clinical progress diseases, aiming explore possibility potential mechanisms reversing aging.

Language: Английский

Citations

0
Advancements in Stem Cell Research for Effective Therapies Against Alzheimer’s Disease: Current Investigation and Future Insight DOI
Abhinav Gupta, Arya Ghosh, Neelima Sharma

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders DOI Open Access
Anyuan Zhang, Qiubai Li, Zhichao Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 225 - 225

Published: Dec. 30, 2024

The global issue of aging populations has become increasingly prominent, thus the research and development for anti-aging therapies to assure longevity as well ameliorate age-related complications is put high on agenda. young humoral milieu been substantiated impart youthful characteristics aged cells or organs. Extracellular vesicles (EVs) are a heterogeneous group cell-derived membrane-limited structures that serve couriers proteins genetic material regulate intercellular communication. Of note, EVs appeared be an indispensable component blood in prolonging lifespans, circulating have indicated mediate beneficial effect aging. Human umbilical cord mesenchymal stem (HUCMSC-EVs), isolated from youngest adult cell source, speculated reproduce function partially revitalize numerous organs old animals. Robust evidence suggested HUCMSC-EVs muti-target therapeutic agents combating alleviating degenerative disorders. Here, we provide comprehensive overview effects brain, heart, vasculature, kidney, muscle, bone, other Furthermore, critically discuss current investigation engineering strategies HUCMSC-EVs, intending unveil their full potential field research.

Language: Английский

Citations

2
The function and effectiveness of MSCs in preclinical models of diseases DOI
Z. Xie, Hu Zhou,

Tingting Ou

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: July 4, 2024

Mesenchymal stem cells (MSCs) have shown immense promise across diverse fields, particularly in treating various diseases. A multitude of preclinical investigations, encompassing both laboratory cellular-level studies and animal trials, demonstrated the significant effectiveness MSCs addressing a broad spectrum These collectively highlight enormous potential therapies utilizing range medical scenarios. From neurological cardiovascular disorders to autoimmune musculoskeletal disorders, including recent challenges like COVID-19, present therapeutic possibilities due their versatile capabilities. discoveries lay robust foundation for further clinical research eventual translation MSC-based treatments into mainstream practice, offering renewed optimism patients contending with complex conditions.

Language: Английский

Citations

0