Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression? DOI Creative Commons

Michael Maes,

Yingqian Zhang, Kitiporn Plaimas

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood (MDMD), are distinguished by the activation of immune-inflammatory response system, T cell activation, a relative regulatory suppression. Nevertheless, these immune data were not used to characterize features protein-protein interaction (PPI) network MDMD. Objectives To identify network's nodes bottlenecks as well biological processes that overrepresented in PPI network, we conducted annotation, enrichment analyses. Results The analysis has identified following backbone genes: tumor necrosis factor-α (TNF), interleukin (IL)6, CXCL12, CXCL10, CCL5, cluster differentiation (CD)4, CD8A, human leukocyte antigen (HLA)-DR, FOXP3. A “cellular defense response”, an “immune system “a viral process involves protein with cytokines cytokine receptors” all highly associated network. chemokine TNF nuclear factor-κB (NFKB) pathways additional enriched Molecular complex detection extracted one component from data, including receptors “regulated RELA” (an NFKB subunit). Conclusions Viral may underlie cells networks Future research on pathogenesis MDMD MDD should examine whether which infections onset conditions, or reactivation is recurrence illness.

Language: Английский

The putative role of immune-inflammatory mechanisms in nociplastic pain pathways: a narrative review DOI Creative Commons
Mariateresa Giglio, Alberto Corriero,

Angela Preziosa

et al.

Exploration of Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Nociplastic pain is the fourth category of defined in recent years. It a arising from altered nociception, despite lack clear evidence actual or threatened tissue damage that causes activation peripheral nociceptors nor for disease lesion somatosensory system causing pain. This type usually multifocal, more diffuse intense than expected and it associated with other central nervous system-derived symptoms, such as fatigue, sleep, memory, mood problems. can occur isolation part mixed-pain state combination ongoing nociceptive neuropathic increased social sanitary costs due to difficulty adequately treating it. Its pathogenesis still poorly understood, even if mounting body suggests pivotal role inflammation immunity, which may be triggered by an infection and/or trauma. narrative review aims summarise current knowledge about interplay immune nociplastic pathways amplification. The challenge future will identify exact cause this activation, its link pathogenetic factors pain, diet microbiota alteration, phycological factors, together genetic epigenetic predisposition.

Language: Английский

Citations

0
Effectiveness of Photobiomodulation Therapy in the Management of Fibromyalgia Syndrome: A Systematic Review DOI Creative Commons
Sebastián Eustaquio Martín Pérez,

Joel Rodríguez Niebla,

Laisyn Posada Pérez

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4161 - 4161

Published: April 10, 2025

Fibromyalgia syndrome is a chronic pain condition involving altered nociceptive processing, which requires multidisciplinary management. Photobiomodulation therapy (PBMT) has recently emerged as promising non-pharmacological approach, but its clinical effectiveness and optimal application methods remain unclear. This systematic review evaluated the efficacy of PBMT in managing symptoms, including pain, physical function, sleep quality, overall well-being, while comparing localized whole-body delivery. A was conducted accordance with PRISMA guidelines previously registered on PROSPERO (CRD42024626368). Literature searches were performed across MEDLINE ((PubMed)), PEDro, SPORTDiscus, Scopus, Elsevier (ScienceDirect), Web Science (WOS), identifying 17 eligible studies (n = 857 participants). applied via low-level laser, infrared, or LED-based devices, delivered either locally to whole body. The methodological quality assessed using PEDro scale, risk bias RoB 2.0 tool. showed significant benefits, reduced intensity, improved decreased fatigue, enhanced life. Whole-body greater more sustained effects than applications, likely due systemic modulation pathways autonomic regulation. Improvements also observed terms psychological kinesiophobia. In conclusion, appears be an effective therapeutic option for syndrome, applications offering superior benefits. However, variability treatment parameters study methodologies underscores need standardized protocols high-quality trials support integration into management strategies.

Language: Английский

Citations

0
Effects of Mental Disorders on Fibromyalgia Mediated by Insomnia: A Mendelian Randomization Study DOI Creative Commons
Le Chang, Zhen Sun, Shan Zeng

et al.

Journal of Pain Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4277 - 4288

Published: Dec. 1, 2024

Background: This study employed Mendelian randomization (MR) analysis to confirm the causal effects of mental disorders on fibromyalgia.Methods: The summary data for exposures, mediator, and outcome were extracted from GWAS catalog project, IEU openGWAS Finn biobank database.Significantly associated independent single-nucleotide polymorphisms (SNPs) meeting criteria p < 5×10-8, r2 0.001, kb = 10,000 selected MR analysis.We used univariate multivariate (i) investigate relationship between disorders/insomnia fibromyalgia (ii) examine mediating role insomnia.The inverse variance weighted (IVW) method along with other methods was analysis, while sensitivity analyses conducted assess reliability stability. Results:The results provided strong evidence positive associations depression (OR 6.749; 95% CI: 2.293-19.868,P 0.001), irritability (OR: 1.873, 1.023-3.428,P 0.042), insomnia 8.395, 1.384-50.931,P 0.021), fibromyalgia.Moreover, a detected 1.230; 1.178-1.285;P 1.084; 1.046-1.122;P 0.001) insomnia.Multivariate showed that mediated fibromyalgia, proportion insomnia-mediated cases ranged 25.2% 26%. Conclusion:This depression, irritability, insomnia, fibromyalgia.Insomnia partly mediates this overall effect.Understanding may provide more information intervention prevention strategies.

Language: Английский

Citations

1
Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression? DOI Creative Commons
Michael Maes, Yingqian Zhang, Kitiporn Plaimas

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood (MDMD), are distinguished by the activation of immune-inflammatory response system, T cell activation, a relative regulatory suppression. Nevertheless, these immune data were not used to characterize features protein-protein interaction (PPI) network MDMD. Objectives To identify network’s nodes bottlenecks as well biological processes that overrepresented in PPI network, we conducted annotation, enrichment analyses. Results The analysis has identified following backbone genes: tumor necrosis factor-α (TNF), interleukin (IL)6, CXCL12, CXCL10, CCL5, cluster differentiation (CD)4, CD8A, human leukocyte antigen (HLA)-DR, FOXP3. A “cellular defense response”, an “immune system “a viral process involves protein with cytokines cytokine receptors” all highly associated network. chemokine TNF nuclear factor-κB (NFKB) pathways additional enriched Molecular complex detection extracted one component from data, including receptors “regulated RELA” (an NFKB subunit). Conclusions Viral may underlie cells networks Future research on pathogenesis MDMD MDD should examine whether which infections onset conditions, or reactivation is recurrence illness.

Language: Английский

Citations

0
Do viral-associated pathways underlie the immune activation during the acute phase of severe major depression? DOI Creative Commons

Michael Maes,

Yingqian Zhang, Kitiporn Plaimas

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Background Major depressive disorder (MDD) and its most severe phenotype, major dysmood (MDMD), are distinguished by the activation of immune-inflammatory response system, T cell activation, a relative regulatory suppression. Nevertheless, these immune data were not used to characterize features protein-protein interaction (PPI) network MDMD. Objectives To identify network's nodes bottlenecks as well biological processes that overrepresented in PPI network, we conducted annotation, enrichment analyses. Results The analysis has identified following backbone genes: tumor necrosis factor-α (TNF), interleukin (IL)6, CXCL12, CXCL10, CCL5, cluster differentiation (CD)4, CD8A, human leukocyte antigen (HLA)-DR, FOXP3. A “cellular defense response”, an “immune system “a viral process involves protein with cytokines cytokine receptors” all highly associated network. chemokine TNF nuclear factor-κB (NFKB) pathways additional enriched Molecular complex detection extracted one component from data, including receptors “regulated RELA” (an NFKB subunit). Conclusions Viral may underlie cells networks Future research on pathogenesis MDMD MDD should examine whether which infections onset conditions, or reactivation is recurrence illness.

Language: Английский

Citations

0