Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

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Polyphenols improve non‐alcoholic fatty liver disease via gut microbiota: A comprehensive review

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(8), P. 5341 - 5356

Published: June 7, 2024

Abstract Polyphenols, natural micronutrients derived from plants, are valued for their anti‐inflammatory and antioxidant properties. The escalating global prevalence of non‐alcoholic fatty liver disease (NAFLD) underscores its status as a chronic progressive condition. Furthermore, the dysregulation gut microbiota (GM) is implicated in onset progression NAFLD through actions metabolites such bile acids (BAs), lipopolysaccharide (LPS), choline, short‐chain (SCFAs). Additionally, GM may influence integrity intestinal barrier. This review aims to evaluate potential effects polyphenols on barrier function, subsequent impact NAFLD. We searched wide range databases, Web Science, PubMed, EMBASE, Scopus gather information our non‐systematic English literature. functions composition can be regulated by chlorogenic acid, curcumin, green tea catechins, naringenin, quercetin, resveratrol, sulforaphane. Regulating improves alleviating inflammation, fat accumulation, enzymes. it serum lipid profile integrity. All these components affect GM, including SCFAs, LPS, BAs. Current evidence indicates that curcumin modulate improving positively impacting More studies necessary safety efficacy sulforaphane, catechin.

Language: Английский

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Associations of the Intake of Individual and Multiple Flavonoids with Metabolic Dysfunction Associated Steatotic Liver Disease in the United States

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 205 - 205

Published: Jan. 7, 2025

Evidence regarding the individual and combined impact of dietary flavonoids on risk metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate association between multiple MASLD in adults. Data sets were obtained from National Health Nutrition Examination Survey (NHANES), 2017-2018. In total, 2581 participants aged over 18 years, complete information flavonoid intake, MASLD, covariates, included. Flavonoid intake was energy-adjusted using residual method. Logistic regression analysis employed examine total MASLD. Weighted quantile sum (WQS) analyses used effects identify predominant types most significant contribution prevention. The highest tertile a 29% reduction compared lowest after multivariable adjustments (OR: 0.71, 95% CI: 0.51-0.97). WQS revealed that anthocyanidins, flavones, flavanones critical contributors among six subclasses (weights = 0.317, 0.279, 0.227, respectively) naringenin, apigenin, delphinidin 29 monomers. 0.240, 0.231, 0.114, respectively). Also, higher linked reduced (p < 0.05). findings suggested lower flavanones, delphinidin, myricetin contributing protective flavonoids.

Language: Английский

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Exploration of capsaicin-encapsulated lignin nanoparticles for alleviating non-alcoholic fatty liver disease: In-vitro study

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140616 - 140616

Published: Feb. 3, 2025

Language: Английский

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Metabolic dysfunction–associated steatotic liver disease and the gut microbiome: pathogenic insights and therapeutic innovations

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(7)

Published: March 31, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of worldwide, and our understanding its pathogenesis continues to evolve. MASLD progresses from steatosis steatohepatitis, fibrosis, cirrhosis, this Review explores how the gut microbiome their metabolites contribute pathogenesis. We explore complexity importance intestinal barrier function disruptions dysbiosis work in concert promote onset progression MASLD. The focuses on specific bacterial, viral, fungal communities that impact trajectory (including ethanol, bile acids, short chain fatty other metabolites) Finally, we underscore knowledge interaction between microbes may be leveraged for microbial-based therapeutics. Here, include discussion therapeutic potential prebiotics, probiotics, postbiotics, microbial-derived metabolites.

Language: Английский

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Identification of Polyphenols in Mallotus peltatus (Geiseler) Mull. Arg. Based on UPLC‐MS/MS and Their Protective Effects on H₂O₂‐Induced Liver Injury

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Liver cells are particularly susceptible to mitochondrial dysfunction due external stimuli, leading excess reactive oxygen species (ROS) and redox imbalance. The aim of this study was extract purify the polyphenolic fractions Mallotus peltatus (Geiseler) Mull. Arg. evaluate their potential protective effect against H 2 O ‐induced oxidative stress injury in hepatocytes. Methods: extraction process polyphenols MPMA optimized by response surface method. Then, we purified crude extracts with macroporous resin HPD600 obtain MPMAP‐I, MPMAP‐II, MPMAP‐III. physical properties component composition samples were analyzed FT‐IR UPLC‐MS/MS. An vitro model hepatocytes established investigate MPMAP‐I on L02 cells. assessed measuring cell survival rate, enzyme activities, intracellular ROS levels, apoptosis membrane potential, mRNA expression related signaling pathways. Results: results showed that conditions 60% ethanol, 140 min, 85°C, liquid‐to‐solid ratio 30 mL/g. All three contained different (such as kaempferol 3‐O‐sophoroside, corilagin, cirsiliol) had great antioxidant activities. treatment could increase activities SOD, CAT, GPx cells, reduce content MDA, transaminases, production ROS, rate apoptosis, restore function. Furthermore, these effects might be inactivation Bcl2/Bax/caspase‐3 apoptotic pathway activation Nrf2/γ‐GCL pathway. Conclusion: Our provided a theoretical basis for liver injury, which is helpful improve development application medicine healthcare products.

Language: Английский

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Associations Between MASLD, Ultra-Processed Food and a Mediterranean Dietary Pattern in Older Adults

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1415 - 1415

Published: April 23, 2025

Background/Objectives: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most common liver disease worldwide, affecting 38% of adult population globally. Methods: We examined impact Mediterranean Diet and Ultra Processed Food (UPF) intake on risk prevalent MASLD in older adults. Results: Our major findings include that increased adherence to a Dietary pattern was associated with decreased MASLD. Additionally, we found high UPF an Furthermore, our study even intake, if individual also had higher compared lower intake. Conclusions: These results are particular importance people, given known links between MASLD, metabolic comorbidities frailty. Public health messaging should focus promoting dietary habits, ways help people achieve this social economic barriers they may face.

Language: Английский

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Optimizing hepato-metabolic health with lifestyle modifications: A comprehensive review

Journal of Integrative Medicine and Research, Journal Year: 2025, Volume and Issue: 3(2), P. 84 - 90

Published: April 1, 2025

Hepatoprotection involves protecting the liver from damage or disease, and addressing lifestyle factors such as diet weight is critical in this regard. Metabolic dysfunction-associated steatotic disease (MASLD), alcoholic other chronic conditions are often exacerbated by poor dietary habits, sedentary behavior, obesity. Excess caloric intake, particularly refined carbohydrates saturated fats, contributes to hepatic fat accumulation inflammation. Dietary patterns Mediterranean diet, rich monounsaturated fiber, antioxidants, have shown hepatoprotective effects reducing steatosis improving metabolic parameters. In addition, omega-3 fatty acids demonstrated efficacy lowering content. Emerging evidence suggests that coffee consumption may reduce risk of MASLD hepatocellular carcinoma, though further research needed. Weight loss remains cornerstone management, with a 7%–10% reduction body significantly histology. Even modest (≥5%) has been associated decreased steatosis. Caloric restriction, intermittent fasting, structured interventions play crucial role achieving sustainable loss. Physical activity complements modifications enhancing insulin sensitivity, accumulation, systemic Both aerobic resistance exercises contribute hepatoprotection, programs yielding optimal benefits. Despite robust supporting interventions, adherence challenge due socioeconomic psychological barriers. Future should explore personalized nutrition approaches, leveraging digital health technologies for sustained behavior change. This review explores how modifications, improve health.

Language: Английский

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Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

In recent years, the prevalence of chronic liver diseases, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), has increased significantly. This upward trend is largely associated with lifestyle-related factors such as unhealthy dietary habits, physical inactivity, and various environmental influences. Among key elements contributing to pathogenesis MASLD, integrity intestinal epithelial barrier emerges a critical determinant, given its central role in maintaining immune homeostasis along gut-liver axis. Disruption this barrier, often driven by excessive consumption saturated fats refined carbohydrates combination low fiber intake, can lead microbial dysbiosis. imbalance gut microbiota triggers dysregulation promotes systemic inflammation, thereby exacerbating hepatic injury. review discusses contribution dysfunction development progression particular focus on how permeability may initiate sustain inflammation. Additionally, influence integrity, responses, inflammatory cascade addressed. A better understanding complex interplay between impairment, modulation, pathology offer valuable insights into MASLD pathophysiology contribute more targeted therapeutic strategies.

Language: Английский

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The Polyphenols from <i>Mallotus Peltatus</i> (Geiseler) Mull. Arg. Protect Against H ₂O ₂-Induced Liver Injury in L02 Cells

Published: Jan. 1, 2024

Language: Английский

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