Exercise mediates myocardial infarction via non-coding RNAs DOI Creative Commons
Changseok Han, Chenggong Zhai, Ailing Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 1, 2024

Myocardial infarction (MI), a widespread cardiovascular issue, mainly occurs due to blood clot formation in the coronary arteries, which reduces flow heart muscle and leads cell death. Incorporating exercise into lifestyle can significantly benefit recovery reduce risk of future cardiac events for MI patients. Non-coding RNAs (ncRNAs) play various roles effects on myocardial (MI). ncRNAs regulate gene expression, influence remodeling, angiogenesis, inflammation, oxidative stress, apoptosis, cardioprotection, electrophysiology. The expression specific is altered by exercise, leading beneficial changes structure, function, after MI. These modulate molecular pathways that contribute improved health, including reducing enhancing promoting survival, mitigating stress. Furthermore, they are involved regulating such as hypertrophy fibrosis, electrical properties heart, thereby decreasing arrhythmias. Knowledge has entered new phase, with investigations physical yielding invaluable insights impact this therapeutic modality. This review compiled research MI, an emphasis their applicability activity.

Language: Английский

Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis DOI Creative Commons
Cong Chen, Jie Wang,

Shan Zhang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103321 - 103321

Published: Aug. 19, 2024

Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.

Language: Английский

Citations

7
Epigenetic Regulation by lncRNA GAS5/miRNA/mRNA Network in Human Diseases DOI Open Access

Lam Ngoc Thao Nguyen,

Jaeden S. Pyburn,

N. Nguyen

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1377 - 1377

Published: Feb. 6, 2025

The interplay between long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) is crucial in the epigenetic regulation of mRNA protein expression, impacting development progression a plethora human diseases, such as cancer, cardiovascular disease, inflammatory-associated viral infection. Among many lncRNAs, growth arrest-specific 5 (GAS5) has garnered substantial attention for its evident role significant biological processes proliferation, differentiation, senescence, apoptosis. Through miRNA-mediated signaling pathways, GAS5 modulates disease cell-type-specific manner, typically by influencing proteins involved inflammation cell death. While recognized tumor suppressor recent reports highlight broader regulatory capacity non-cancerous diseases. Its modulation expression through GAS5/miRNA network been shown to both mitigate exacerbate depending on specific context. Furthermore, therapeutic potential manipulation, via knockdown or overexpression, offers promising avenues targeted interventions across This review explores dualistic impacts conditions infections, inflammatory disorders. evaluation current evidence, we aim provide insight into GAS5's functions implications future research development.

Language: Английский

Citations

0
m6A modification in non-coding RNAs: Mechanisms and potential therapeutic implications in fibrosis DOI Open Access

Yutong Zhou,

Ni Jian, Canhua Jiang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117331 - 117331

Published: Aug. 26, 2024

N6-methyladenosine (m

Citations

1
Exercise mediates myocardial infarction via non-coding RNAs DOI Creative Commons
Changseok Han, Chenggong Zhai, Ailing Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 1, 2024

Myocardial infarction (MI), a widespread cardiovascular issue, mainly occurs due to blood clot formation in the coronary arteries, which reduces flow heart muscle and leads cell death. Incorporating exercise into lifestyle can significantly benefit recovery reduce risk of future cardiac events for MI patients. Non-coding RNAs (ncRNAs) play various roles effects on myocardial (MI). ncRNAs regulate gene expression, influence remodeling, angiogenesis, inflammation, oxidative stress, apoptosis, cardioprotection, electrophysiology. The expression specific is altered by exercise, leading beneficial changes structure, function, after MI. These modulate molecular pathways that contribute improved health, including reducing enhancing promoting survival, mitigating stress. Furthermore, they are involved regulating such as hypertrophy fibrosis, electrical properties heart, thereby decreasing arrhythmias. Knowledge has entered new phase, with investigations physical yielding invaluable insights impact this therapeutic modality. This review compiled research MI, an emphasis their applicability activity.

Language: Английский

Citations

1