Boron Neutron Capture Therapy with Boronophenylalanine in Experimental Oncology and Veterinary Practice DOI Open Access
Yu. А. Finogenova, А. А. Lipengolts, K. E. Shpakova

et al.

Journal of oncology diagnostic radiology and radiotherapy, Journal Year: 2024, Volume and Issue: 7(4), P. 28 - 39

Published: Dec. 26, 2024

Neutron Capture Therapy (NCT) — highly selective method of binary radiotherapy malignancies, which is based on physical phenomenon thermal neutron radiation capture by atoms’ nuclei. Currently only 10B mediated NCT, known as boron therapy (BNCT), used in clinical practice. Boronophenylalanine a modified amino acid most widely carrier. Despite more than 70-years history BCNT application and promising results curing patients with different tumors, this treatment still under research development. The urgent issue studying prediction effects healthy tumor tissues after BNCT application. This task can be solved experiments involving animals. review contains studies both laboratory animals models veterinary Induced transplanted central nervous system, oral cavity well subcutaneous metastatic are considered the review. Obtained show possible high antitumor efficacy BPA fundamentally mechanisms effect comparing to other types radiotherapy. Many issues require addition modern methods studies, such vivo preclinical imaging.

Language: Английский

Development of Structurally Identical Therapeutic and Diagnostic Agents for Image-Guided Boron Neutron Capture Therapy: c(RGD-BPA-K) Peptide with 125I/natI Albumin-Binding Moiety DOI

Iqra Bibi,

Kyung Jun Kang,

Jung Young Kim

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

The development of boron neutron capture therapy (BNCT) agents and structurally similar radiolabeled counterparts for diagnostic imaging is an area significant interest. In this study, we designed same compounds, c(RGD-BPA-K)(PEG2-(4-iodophenylbutyl)) (compound 1) its radioiodinated counterpart, c(RGD-BPA-K)(PEG2-(4-[125I]iodophenylbutyl)) ([125I]1), efficient BNCT SPECT/CT imaging, respectively. An albumin-binding moiety was introduced into the compound to enhance blood circulation time tumor accumulation. We evaluated efficacy 1 [125I]1 in U87MG tumor-bearing mice using biodistribution analysis, inductively coupled plasma mass spectrometry. Both displayed pharmacokinetics, high retention, substantial accumulation tumors. This study highlights potential SPECT/CT-guided BNCT. structural identity between therapeutic can efficacy. Further modifications increase concentration tumors, as well thermal irradiation studies, may be necessary fully explore our novel agent.

Language: Английский

Citations

0
Boron Neutron Capture Therapy with Boronophenylalanine in Experimental Oncology and Veterinary Practice DOI Open Access
Yu. А. Finogenova, А. А. Lipengolts, K. E. Shpakova

et al.

Journal of oncology diagnostic radiology and radiotherapy, Journal Year: 2024, Volume and Issue: 7(4), P. 28 - 39

Published: Dec. 26, 2024

Neutron Capture Therapy (NCT) — highly selective method of binary radiotherapy malignancies, which is based on physical phenomenon thermal neutron radiation capture by atoms’ nuclei. Currently only 10B mediated NCT, known as boron therapy (BNCT), used in clinical practice. Boronophenylalanine a modified amino acid most widely carrier. Despite more than 70-years history BCNT application and promising results curing patients with different tumors, this treatment still under research development. The urgent issue studying prediction effects healthy tumor tissues after BNCT application. This task can be solved experiments involving animals. review contains studies both laboratory animals models veterinary Induced transplanted central nervous system, oral cavity well subcutaneous metastatic are considered the review. Obtained show possible high antitumor efficacy BPA fundamentally mechanisms effect comparing to other types radiotherapy. Many issues require addition modern methods studies, such vivo preclinical imaging.

Language: Английский

Citations

0