Possible link between steatotic liver diseases, severe COVID-19 and cognitive impairment in post-COVID-19 syndrome
Philipp Reuken,
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Freya Wagner,
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Kathrin Finke
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et al.
Infection,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Abstract
Purpose
Steatotic
liver
diseases
(SLD)
have
become
more
prevalent
over
the
last
decade
and
are
associated
not
only
with
cardiometabolic
but
also
psychological
symptoms
(depression,
fatigue).
These
common
in
post-COVID
syndrome
(PCS).
Therefore,
aim
of
study
was
to
analyze
burden
SLD
PCS
patients.
Methods
We
systematically
screened
all
patients
from
our
outpatient
clinic
using
transient
elastography,
structured
questionnaires
for
neurocognitive
evaluation
blood
sample
analysis.
Controls
without
known
were
recruited
assessed
same
approach.
Results
560
103
healthy
controls
included.
The
overall
prevalence
high
both
cohorts
(57
vs.
53%).
frequently
male
(41
24%),
older
(52
44
years)
had
(87.0
46.4%).
Cognitive
impairment
related
than
no-SLD
group
(OR:
1.68,
CI:
1.14–2.46,
p
=
0.008).
presence
severe
COVID-19
hospitalization
2.91,
1.85–4.56,
<
0.001).
Within
1
year
follow-up,
152
289
described
a
resolution
irrespective
or
absence
(log-rank
0.96).
Conclusions
is
cognitive
dysfunction
PCS.
Longitudinal
studies
needed
assess
role
hepatic
steatosis,
development
post-acute
infection
regulation
(e.g.,
SARS-CoV-2)
differentiate
between
SLD-associated
Language: Английский
Developing a clinical-pathological framework of long COVID-related fatigue applied to public safety workers
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: July 17, 2024
In
the
wake
of
COVID-19
pandemic,
millions
worldwide
are
still
struggling
with
persistent
or
recurring
symptoms
known
as
long
COVID.
Fatigue
is
one
most
prevalent
associated
COVID,
and
for
many
it
can
be
debilitating.
Understanding
potential
pathological
processes
that
link
fatigue
to
COVID
critical
better
guide
treatment.
Challenges
diagnosis
treatment
reviewed,
recognizing
post-COVID
does
not
always
present
corroborating
clinical
evidence,
a
situation
frustrating
both
patients
healthcare
providers.
Firefighters
group
public
safety
workers
who
particularly
impacted
by
COVID-related
fatigue.
must
able
engage
in
strenuous
physical
activity
deal
demanding
psychological
situations,
which
may
difficult
those
suffering
from
Disruption
worker
health
potentially
impact
community
welfare.
This
review
creates
framework
explain
clinical-pathological
features
resulting
addresses
challenges,
explores
unique
pose
their
organizations.
Language: Английский