Identification of key exosomes-related genes in hepatitis B virus-related hepatocellular carcinoma DOI Creative Commons
Zhuoyi Wang,

Jian‐Fang Lu,

Xiangyan Liu

et al.

Technology and Health Care, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

One of the primary risk factors for hepatocellular carcinoma (HCC) is hepatitis B virus (HBV). Exosomes have a significant impact on dissemination HBV-infected HCC. This study aimed to screen HBV exosome-related hub genes in HCC better understanding pathogenic mechanism. First, multiple HBV-induced datasets were collected from Gene Expression Omnibus (GEO) database, and gene set was obtained relevant literature. Nine HBV-related exosome (HP, C9, APOA1, PON1, TTR, LPA, FCN2, FCN3, MBL2) selected through differential analysis network analysis. An receiver operation characteristic (ROC) revealed that these had good diagnostic value. These primarily enriched biological processes such as citrate cycle tca cycle, phenylalanine metabolism, fatty acid according enrichment (GSEA). Furthermore, this predicted miRNA (hsa-miR-590-5p) targeting well 12 lncRNAs (AL121655, SAP30-DT, LINC00472, etc.) hsa-miR-590-5p. Finally, nelarabine, methylprednisolone, methylprednisolone be possible medications target based CellMiner database. To sum up, work crucial discovering new biomarkers comprehending function growth

Language: Английский

Lipoprotein subclasses and gastrointestinal cancers: novel perspectives and potential associations DOI Creative Commons
Chuang Yang, Dong Liu, Yong Wang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 3, 2025

Background This study aimed to investigate the associations between serum lipoprotein subclasses and long-term risk of gastrointestinal (GI) cancers enhance our understanding etiology GI cancers. Methods prospective cohort included 249,450 participants from UK Biobank. Cox proportional hazard models were used assess association 17 with Restricted cubic spline (RCS) analysis was employed corresponding dose–response relationships. Additionally, Mendelian randomization (MR) evaluate causal relationships lipoproteins Results A total 4,787 cases recorded over a median follow-up period 12.92 years. Our results revealed that majority high-density (HDL) subclasses, such as very large-, medium-HDL-particles, positively associated, while several low-density (LDL) negatively associated overall cancer. RCS linear relationship elevated levels most particles cancer development. subgroup indicated significant sex-dependent interaction However, MR different at genetic level. Conclusion In this large-scale metabolomics study, we identified further research is needed fully elucidate their roles in mechanisms

Language: Английский

Citations

0
The causal relationship between hepatitis B, immunophenotypes and liver cancer: a Mendelian randomization study DOI Creative Commons

Zhili Cao,

Chunyu Zhang, Shan Chen

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 5, 2025

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally, and infection with hepatitis B virus (HBV) one major risk factors for development HCC. However, definitive causal relationship between HBV liver cancer has not been clearly established. In this study, we employed Mendelian randomization (MR) to estimate effect on hepatocellular by using genetic variations as instrumental variables. We obtained summary statistics from genome-wide association studies (GWAS) related B. conducted analysis, variants associated variables cancer. our MR inverse variance weighted (IVW) method performed sensitivity analyses robustness assessments Egger regression median method. Our analysis revealed a significant association, indicating that leads (IVW odds ratio = 2.233, 95% confidence interval 1.844-2.703, P < 0.001). Sensitivity confirmed effect, no evidence horizontal pleiotropy. Similar results were observed across different methods, supporting strong risk. Specifically, CD25 IgD-CD38- cell subset (β 1.15, CI 1.07-1.24, 3.0 × 10^- 4). Additionally, five immune phenotypes significantly HCC risk: HLA DR + monocytes. This study demonstrates risk, highlighting potential factor in carcinoma.

Language: Английский

Citations

0
A mendelian randomization study on the association between type 2 diabetes and the risk of bladder cancer DOI Creative Commons
Yuan He, Yu Chen, Chang Gao

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

We used Mendelian randomization (MR) analyses to examine the potential causal effects of type 2 diabetes and glycemic traits on bladder cancer risk. Two-sample MR were conducted using summary data from genome-wide association studies (GWAS). Exposures included diabetes, fasting glucose, glycosylated hemoglobin (HbA1c), insulin, proinsulin levels, with as outcome. Four methods-inverse variance weighted, MR-Egger, weighted median, mode-were assess effects. Sensitivity ensure that results robust. In inverse model, a weak positive effect was detected between genetically predicted HbA1c (OR = 1.003, 95% CI 1.0001 1.0052, P 0.043). Other methods produced same trend, although not all statistically significant. However, there no evidence support or levels cancer. No significant heterogeneity pleiotropy detected. analysis indicated mild promoting increased Further larger sample sizes are needed confirm this hypothesis.

Language: Английский

Citations

0
An atlas on risk factors for gastrointestinal cancers: A systematic review of Mendelian randomization studies DOI
Yixuan Huang, Junhua Wu,

Yuqiang Zhao

et al.

Preventive Medicine, Journal Year: 2024, Volume and Issue: 189, P. 108147 - 108147

Published: Oct. 3, 2024

Language: Английский

Citations

3
Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies DOI Creative Commons
Naouras Bouajila, Cloé Domenighetti, Henri‐Jean Aubin

et al.

Frontiers in Epidemiology, Journal Year: 2024, Volume and Issue: 4

Published: Nov. 7, 2024

Background The health effects of alcohol consumption, particularly regarding potential protective benefits light to moderate intake compared abstinence, remain a subject ongoing debate. However, epidemiological studies face limitations due imprecise exposure measurements and the for bias through residual confounding reverse causation. To address these limitations, we conducted systematic review Mendelian Randomization (MR) examining causal relationship between consumption cancers, cardiovascular, liver, neurological diseases. Methodology We searched PubMed, ScienceDirect Embase Europe PMC up 05/2024 MR investigating association genetically predicted with liver assessed methodological quality based on key elements design genetic tool. Results included 70 that matched our inclusion criteria. Our showed significant multiple cancers such as oral oropharyngeal, esophageal, colorectal hepatocellular carcinoma cutaneous melanoma. While available did not consistently confirm adverse or other lung cancer, suggested by observational studies. Additionally, confirmed likely effect risk hypertension, atrial fibrillation, myocardial infraction vessels disease. there was no evidence support cognitive function, Alzheimer's disease, amyotrophic lateral sclerosis, reported in while revealed an increased epilepsy sclerosis. provided limited results link Conclusions Despite valuable insights into various outcomes provided, it is worth noting inconsistent ability instrumental variables distinguish abstainers, drinkers makes difficult differentiate U J-shaped vs. linear relationships outcome. Additional research necessary establish formal assessment tools conduct more diverse populations, including non-European ancestries. Systematic Review Registration www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021246154 , Identifier: PROSPERO (CRD42021246154).

Language: Английский

Citations

0
Identification of key exosomes-related genes in hepatitis B virus-related hepatocellular carcinoma DOI Creative Commons
Zhuoyi Wang,

Jian‐Fang Lu,

Xiangyan Liu

et al.

Technology and Health Care, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

One of the primary risk factors for hepatocellular carcinoma (HCC) is hepatitis B virus (HBV). Exosomes have a significant impact on dissemination HBV-infected HCC. This study aimed to screen HBV exosome-related hub genes in HCC better understanding pathogenic mechanism. First, multiple HBV-induced datasets were collected from Gene Expression Omnibus (GEO) database, and gene set was obtained relevant literature. Nine HBV-related exosome (HP, C9, APOA1, PON1, TTR, LPA, FCN2, FCN3, MBL2) selected through differential analysis network analysis. An receiver operation characteristic (ROC) revealed that these had good diagnostic value. These primarily enriched biological processes such as citrate cycle tca cycle, phenylalanine metabolism, fatty acid according enrichment (GSEA). Furthermore, this predicted miRNA (hsa-miR-590-5p) targeting well 12 lncRNAs (AL121655, SAP30-DT, LINC00472, etc.) hsa-miR-590-5p. Finally, nelarabine, methylprednisolone, methylprednisolone be possible medications target based CellMiner database. To sum up, work crucial discovering new biomarkers comprehending function growth

Language: Английский

Citations

0