Bioinformatics analysis of genes associated with disulfidptosis in spinal cord injury

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318016 - e0318016

Published: Feb. 14, 2025

Research findings indicate that programmed cell death (PCD) plays a pivotal role in the pathophysiology of spinal cord injury (SCI), and recently discovered form death, disulfidptosis, has emerged as novel phenomenon. However, characterization disulfidptosis-related genes SCI remains insufficiently explored. We retrieved SCI-related data from Gene Expression Omnibus (GEO) database identified three key associated with disulfidptosis human (CAPZB, SLC3A2, TLN1), whose mediated signaling pathways are closely intertwined SCI. Subsequent functional enrichment analysis suggested these may regulate multiple exert corresponding roles pathology. Moreover, we predicted potential targeted drugs for along their transcription factors constructed an intricate regulatory network. CIBERSORT revealed CAPZB, TLN1 might be implicated modulating changes within immune microenvironment individuals Our study provides compelling evidence confirming significant involvement following while offering valuable insights into its underlying pathological mechanisms.

Language: Английский

The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(6)

Published: Nov. 22, 2024

Language: Английский