Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(3), P. 1 - 10
Published: Dec. 1, 2024
Language: Английский
Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
Citations
2
ACS Nano, Journal Year: 2025, Volume and Issue: 19(5), P. 5460 - 5474
Published: Jan. 30, 2025
Type-2-diabetes is a metabolic disorder where misfolding and oligomerization of islet amyloid polypeptide (IAPP) around islet-β cells oligomerizes participates in the pathology. The oligomeric stage toxic but transitory leads to formation mature fibrils. pathological specifics fibrils are poorly understood. Here, we demonstrate that IAPP amyloids make gel-like transition, increasing viscosity local microenvironment encasing impeding their ability sense glucose release insulin. Using dual-targeted gold nanoparticles (AuNPs) capped with amyloid-fragments βCasein anti-IAPP antibodies, show X-ray irradiation AuNPs when bound results therapeutic remodelling amyloids, reduction solution, restoration glucose/insulin homeostasis. This study establishes can participate progressive pathology type-2-diabetes by suppressing insulin responsiveness at single islet-cell level. It also identifies model reversal using AuNPs-mediated therapy, this approach be rationally expanded other pathologies, such as Alzheimer's Parkinson's diseases.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140820 - 140820
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125333 - 125333
Published: Feb. 1, 2025
Language: Английский
Citations
0
Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42738 - e42738
Published: Feb. 1, 2025
In recent decades, significant attention has been directed towards gold nanoparticles due to their exceptional properties, capturing the interest of researchers globally. Their unique characteristics, such as localized surface plasmon resonance, high area volume ratio, biocompatibility, and facile functionalization, render them highly suitable for diverse applications, ranging from optoelectronics sensing surface-enhanced spectroscopies biomedical uses, particularly in realm photothermal therapy. Plasmonic therapy, an emerging technology, garnered substantial its potential cancer treatment management. This approach employs agents, nanoparticles, which absorb light near-infrared region. When these agents accumulate within cells, absorbed photon energy is converted into heat, inducing local hyperthermia. effect selectively eliminates damaged cells adjacent while sparing normal cells. Various shapes sizes have proven well-suited candidates paper provides overview distinctive properties nanoparticles. It delves functionalization techniques crucial ensuring cells' effective retention targeting this context, present reviews applications with different plasmonic encompassing nanospheres, nanorods, nanoshells, nanostars, nanocages.
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 317 - 317
Published: Feb. 19, 2025
Gold nanoparticles (GNPs) have gained significant attention as multifunctional agents in biomedical applications, particularly for enhancing radiotherapy. Their advantages, including low toxicity, high biocompatibility, and excellent conductivity, make them promising candidates improving treatment outcomes across various radiation sources, such femtosecond lasers, X-rays, Cs-137, proton beams. However, a deeper understanding of their precise mechanisms radiotherapy is essential maximizing therapeutic potential. This review explores the role GNPs reactive oxygen species (ROS) generation through plasmon-induced hot electrons or radiation-induced secondary electrons, leading to cellular damage organelles mitochondria cytoskeleton. additional pathway enhances efficacy, offering new possibilities. Furthermore, we discuss emerging trends future perspectives, highlighting innovative strategies integrating into comprehensive provides insights mechanisms, potential clinical impact cancer treatment.
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1854 - 1854
Published: Nov. 20, 2024
Gold nanoparticles (NPs) have demonstrated significance in several important fields, including drug delivery and anticancer research, due to their unique properties. NPs possess significant optical characteristics that enhance application biosensor development for diagnosis, photothermal photodynamic therapies treatment, targeted bioimaging. The broad surface modification possibilities of gold been utilized the various molecules, nucleic acids, drugs, proteins. Moreover, strong localized plasmon resonance (LSPR) properties, facilitating use surface-enhanced Raman scattering precise efficient biomolecule detection. These properties are extensively research. Both show results treatments using NPs. Additionally, demonstrate potential other biological areas, particularly antimicrobial activity. In addition delivering antigens, peptides, antibiotics activity, can penetrate cell membranes induce apoptosis through intracellular mechanisms. Among types metal NPs, more tolerable toxicity capacity, supporting wide-ranging areas. hold a special position nanomaterial offering limited This review aims address recently highlighted applications current status NP research discuss future nanomedicine.
Language: Английский
Citations
3
Materials chemistry horizons., Journal Year: 2024, Volume and Issue: 3(3), P. 1 - 10
Published: Dec. 1, 2024
Language: Английский
Citations
0