Bioactive Phytochemicals from Garlic (Allium sativum L.) By-Products

Published: Jan. 1, 2025

Language: Английский

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Current Challenges and Recent Advancements in the Adoption of Omics to Enhance Biofortification

Published: Feb. 27, 2025

Language: Английский

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Ecofriendly synthesis characterization and biological activities of Eruca sativa mediated silver oxide nanoparticles

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

One of the popular subjects millennia is synthesis nanostructures, their applications in numerous fields, and interaction with various biological systems, making them appealing for drug delivery diagnostic therapeutic agents. In this study, silver oxide nanoparticles were synthesized using E. sativa (ES) aqueous extract. The biosynthesis was followed via UV-vis spectroscopy by analysis, FTIR, XRD, TEM, Zeta potential to further analyze nanoparticles. Furthermore, biosynthesized (Ag2ONPs) checked through activities. antioxidative assessed performing a DPPH radical scavenging assay, total reducing power antioxidant capacity assay. Antimicrobial observed against bacterial fungal strains. Likewise, Artemia salina (brine shrimps) used study cytotoxicity, while VERO HEK-293 cell lines applied check biocompatibility NPs. Anticancer evaluated Hep-2 cells utilizing an MTT A mean crystallite ~ 50 nm size evidenced TEM analysis. Notable antimicrobial activity detected strains maximum ZOI B. subtilis 18.5 ± 2.36 mm at 1000 µg/mL A. niger reveals minimum ZOP 16 1.7 respectively. dose-dependent response evaluation (LC50: 12.21 µg/mL), (IC50: 62.36 line 43.11 26.56 9.97 µg/mL). multifaceted attributes ES-Ag2ONPs encompassing antimicrobial, antioxidant, cytotoxic, anticancer properties render versatile platform biomedical horizons. However, detailed investigation clinical trials will undoubtedly provide translational diverse fields.

Language: Английский

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Future Horizons: Emerging “Omics” Technologies and Challenges in Tomato

Published: Jan. 1, 2025

Language: Английский

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Computational identification of PDL1 inhibitors and their cytotoxic effects with silver and gold nanoparticles

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 4, 2024

Immunotherapy is a promising treatment for cancer that aims to boost the immune system's response cells. This can be achieved by blocking Programmed cell death protein 1/Programmed death-ligand 1 (PD1/PDL1), which activates T In this work, aim was find high-affinity drugs against PDL1 using computational tools and conjugate nanoparticles with them. The cytotoxic activity of nanoparticle conjugated then tested. screening 100,000 from ZINC database FDA-approved done computationally. physicochemical properties toxicity were analyzed SwissADME ProTox-II, respectively. Silver (AgNPs) gold (AuNPs) synthesized extracts Catharanthus roseus flowers Juglans regia shells, characterization AgNPs AuNPs performed UV–Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). Their conjugation Irinotecan, Imatinib, Methotrexate also confirmed UV–Vis, FTIR, Dynamic light scattering (DLS). top screened ZINC1098661 3 (Irinotecan, Methotrexate). Docking studies revealed Irinotecan had highest binding affinity towards when silver (AuNPs). Irinotecan-PDL1 complex as most stable through molecular dynamics simulations. result methylthiazol tetrazolium (MTT) assay showed higher toxic effect on A549 line than Imatinib. study provides avenue further investigation development nanoparticle-drug conjugates potential immunotherapy strategy.

Language: Английский

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Potential biological applications of environment friendly synthesized iron oxide nanoparticles using Sageretia thea root extract

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 16, 2024

Abstract The green synthesis of Iron oxide nanoparticles (IONPs) has shown numerous advantages over conventional physical and chemical methods as these non-ecofriendly uses toxic chemicals complicated equipments. In present study, were created using simple, sustainable, eco-friendly chemistry protocol. roots novel medicinal plant Sageretia thea was used a bio-template for the preparation IONPs. Further, IONPs confirmed different analytical tools like UV-Vis, FT-IR, XRD, EDX, SEM. average sizes (NPs) found to be 16.04 nm. asynthesized evaluated several biological potentials including antibacterial, antifungal Anti-radical (DPPH) cytotoxicity assays. Antibacterial potencies investigated bacterial strains (in concentration range 1000–31.25 µg/mL) revealing significant antibacterial potentials. ABA SAU reported least susceptible while KPN observed most strain in bactericidal studies. fungal investigate revealed strong against pathogenic strains. Furthermore, MRA, FA ANI fungicidal examination. Significant potential examined brine shrimps assay, thus cytotoxic IC 50 S. based recorded 33.85 µg/mL. Strong anti-radical assay performed evaluate ROS scavenging S.T@IONPs. highest noted 78.06%, TRP 81.92% TAC 84% on maximum 200 summary, our experimental results concluded, that have antifungal, DPPH can applications. nutshell, as-prepared bioactivities we recommend, other vitro vivo further analyze

Language: Английский

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Rhynchosia capitata driven bioproduction of Zinc oxide nanoparticles, characterization and multifaceted therapeutic applications

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

The current study aimed to formulate zinc oxide nanoparticles (ZnONPs) employing an aqueous extract derived from Rhynchosia capitata (RC). Utilizing several spectroscopic methods (UV-visible spectroscopy, XRD, FTIR, SEM, EDX, DLS), the synthesis of ZnONPs was evaluated. have a mean crystallite size about 32.15 nm, as determined by Scherrer equation. Moreover, in vitro, biological assessments showed notable therapeutic potential. Furthermore, disc diffusion method precisely employed with antibacterial and antifungal properties across range concentrations (100–1500 µg/ml). Among bacteria, B. subtilis displayed prominent inhibition zone, measuring 24 mm at 1500 µg/ml. Similarly, susceptible fungal strains demonstrated zone 29 mm. Antioxidant potentials were using different assays. radical-scavenging capabilities quantified DPPH assay revealed significant result 73%. Further, reducing power calculated found be 69 ± 1.77%, total antioxidant capacity 88 4.8. Brine shrimps cytotoxicity performed LC₅₀ value 2.20 µg/mL, affirming biocompatibility. biocompatibility potential against red blood cells, HEK, VERO cell lines confirm their biosafety An alpha-amylase (AA) percent 70%. Particularly noteworthy efficacy (Hep-2 liver) cancer cells (IC₅₀:44.90). exhibited promising non-toxic attributes substantial for diverse applications in various domains. outcomes this are anticipated contribute valuable insights open new avenues further research development multitude biomedical applications.

Language: Английский

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Biogenic synthesis and characterization of silver nanoparticles (AgNPs) from aqueous extract of Lepidagathis cristata along with their antibacterial and antineoplastic activity to combat breast cancer cells (MCF‐7)

Luminescence, Journal Year: 2024, Volume and Issue: 39(9)

Published: Sept. 1, 2024

Abstract Lepidagathis cristata ( L. ) plant produces reducing and capping agents; this study utilized microwave‐assisted biogenic synthesis to manufacture silver nanoparticles (AgNPs) using plant. The structure, morphology, crystallinity phases of prepared (NPs) were characterized by ultraviolet–visible spectroscopy (UV‐viz), powder X‐ray diffraction (XRD), Fourier‐transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM). Biologically synthesized AgNPs treated against pathogenic bacteria species including Escherichia coli E. ), Bacillus subtilis B. Staphylococcus aureus S. its highest zone inhibition 10 ± 1.45 mm, 0.74 6 0.43 respectively, at the concentration 100 μg/mL. cytotoxic activity MCF‐7 breast cancer cells revealed significant growth inhibiting cell viability, inhibitory 50% (IC 50 NPs observed 55.76 μg/mL concentration. Finally, our findings concluded that ‐mediated biosynthesized proved potential antibacterial neoplastic properties MCF endorsing proliferation especially with low

Language: Английский

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Green Synthesis of Silver Oxide Nanoparticles from Mauritia flexuosa Fruit Extract: Characterization and Bioactivity Assessment

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(23), P. 1875 - 1875

Published: Nov. 22, 2024

The increasing prevalence of multidrug-resistant (MDR) pathogens, persistent biofilms, oxidative stress, and cancerous cell proliferation poses significant challenges in healthcare environmental settings, highlighting the urgent need for innovative sustainable therapeutic solutions. exploration nanotechnology, particularly use green-synthesized nanoparticles, offers a promising avenue to address these complex biological due their multifunctional properties biocompatibility. Utilizing green synthesis approach,

Language: Английский

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Nano-formulation for Agriculture Applicability

Nanotechnology in the life sciences, Journal Year: 2024, Volume and Issue: unknown, P. 325 - 367

Published: Jan. 1, 2024

Language: Английский

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