Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy DOI Creative Commons
Enrico Apa,

Nicole Carrie Tegmeyer,

Concetta D’Adamo

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1237 - 1237

Published: Sept. 27, 2024

Studies about the effects of SARS-CoV-2 on pregnant women and children born to positive are controversial with regard possible inner ear-related damage but most them do not detect involvement this virus in auditory function. However, only a few studies long-term language development currently available because recent onset pandemic. The aim study was investigate impact infection perceptual expressive abilities emerging communication young children. To purpose, MacArthur-Bates Communicative Development Inventory-Words Gestures form (CDI-WG), administered parents. In total, 115 whose mother infected by during pregnancy were enrolled evaluated at Audiology Service Modena University Hospital. All underwent Otoacoustic Emissions (OAE) birth: 114/115 had "pass" result bilaterally, while 1 case unilateral "refer" result. Overall, 110/115 newborns (95.65%) audiological evaluation between 10-18 months age. 5/110 patients (3.6%), Pure Tone Average (PTA) equal 35 dB; one hearing threshold around 50 dB due bilateral effusive otitis media. A notable finding percentage tubal dysfunction both evaluations, within 2 age 12 Most revealed normal hearing. CDI-WG completed 56/115 families. rate below fifth percentile 8.9% for sentences understood, 12.5% words 5.4% produced. Concerning CDI-Gestures, (3.6%) percentile. structured follow-up association skills appears fundamental, particularly years maximum neuroplasticity. Long-term still necessary evaluate consequences

Language: Английский

Neurodevelopmental Follow-Up in Children with Intrauterine and Perinatal Exposure to Chikungunya Virus DOI
Fátima Cristiane Pinho de Almeida Di Maio Ferreira,

Karin Nielsen-Saines,

Maria Elisabeth Lopes Moreira

et al.

The Journal of Pediatrics, Journal Year: 2025, Volume and Issue: unknown, P. 114477 - 114477

Published: Jan. 1, 2025

Language: Английский

Citations

0
Pediatric research with impact: connecting families to developmental resources DOI

Manuela Iglesias,

Daniella S. McCausland,

Lora Jackle

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
The microbiome as a modulator of neurological health across the maternal-offspring interface DOI Creative Commons
Stephanie B. Orchanian, Elaine Y. Hsiao

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(4)

Published: Feb. 16, 2025

The maternal microbiome is emerging as an important factor that influences the neurological health of mothers and their children. Recent studies highlight how microbial communities in gut can shape early-life development ways inform long-term trajectories. Research on neurodevelopmental effects microbiomes expanding our understanding microbiome-gut-brain axis to include signaling across maternal-offspring unit during perinatal period. In this Review, we synthesize existing literature modulates brain function behavior both developing offspring. We present evidence from human animal showing interacts with environmental factors impact risk for abnormalities. further discuss molecular cellular mechanisms facilitate crosstalk neuromodulation. Finally, consider advancing these complex interactions could lead microbiome-based interventions promoting offspring health.

Language: Английский

Citations

0
SARS-CoV-2 Infection and Its Association with Maternal and Fetal Redox Status and Outcomes: A Prospective Clinical Study DOI Open Access
Marija Bicanin Ilic, Tamara Nikolić Turnić, Igor Ilić

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1555 - 1555

Published: Feb. 26, 2025

Background: The impact of the SARS-CoV-2 viral infection during pregnancy on fetus can be direct—transmitted through placenta—and indirect—creating unfavorable conditions for development because inflammation, micro-thrombosis, and hypercoagulation. Our study aimed to determine types frequency pathohistological changes in placental tissue SARS-CoV-2-positive pregnant women examine possible role oxidative stress prognosis delivery its maternal fetal complications. Methods: This prospective clinical included 50 divided into two groups, positive (COVID-19 group) negative (control group), from who we collected demographic, clinical, obstetric, biochemical pathologic data. Data about newborn characteristics were also collected, which anamnestic, Results: values superoxide anion radical index lipid peroxidation significantly different mothers concerning presence infection, while levels nitric oxide, peroxidation, reduced glutathione, dismutase newborns depending infection. Newborn similar between groups except concentrations IgM antibody. incidence FVM type COVID-19 group was 46%, control group, 18%. Conclusions: confirmed significant parameters stress-mediated dysfunction. Future studies should performed with more participants follow-up neonatal development.

Language: Английский

Citations

0
Association Between Severity of COVID-19 and Social Determinants of Health with Adverse Pregnancy Outcomes in a Study of Mother–Infant Pairs in Los Angeles, California DOI Creative Commons

Sarah Daouk,

Tara Kerin, Trevon Fuller

et al.

Women, Journal Year: 2025, Volume and Issue: 5(2), P. 12 - 12

Published: April 2, 2025

Previous cross-sectional studies have investigated social determinants of health (SDOH) among pregnant women with COVID-19. However, there are scant data on the impact these maternal outcomes from cohorts We evaluated association between and both COVID-19 severity adverse pregnancy (APOs) in a cohort Los Angeles (L.A.) County, California. The APOs considered were fetal loss, gestational hypertensive disorders, prolonged rupture membranes, death. recruited confirmed SARS-CoV-2 collected severity, trimester at diagnosis, comorbidities, mode delivery, vaccination, APOs, age, medical insurance type, race/ethnicity, neighborhood income. Participants who obese more likely to experience severe (OR: 3.61, 95% CI: 1.44–9.46), while even one vaccine dose before infection was associated reduced odds disease (OR:0.14, 0.02–0.52). Pregnant participants living low-income areas (p = 0.01) 0.009). This suggests that economic inequities could negatively also found SDOH moderated effects Black vs. non-Black women. These findings underscore importance considering improve health.

Language: Английский

Citations

0
Pregnant individuals perspectives towards receiving COVID-19 vaccination during their pregnancy: an in-depth qualitative study DOI Creative Commons
Sanne J. M. Zilver, Anna L. Rietveld, Noralie N. Schonewille

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 21, 2024

Introduction Pregnant individuals have an increased risk of severe illness from coronavirus disease 2019 (COVID-19) infection. Vaccination is effective strategy to prevent and complications for pregnant individuals. are often excluded research remain hesitant receive vaccination against COVID-19. It pivotal study factors related vaccine uptake hesitancy among We studied barriers facilitators choice motivation regarding COVID-19 during pregnancy aid future in their decision vaccinate various infectious agents. Methods In this qualitative study, were interviewed between October 2021 January 2022 using a semi-structured approach. A topic list was used explore feelings, perceptions ideas pregnancy. Interviews transcribed verbatim thematic analyses performed MAX QDA. Results After nine interviews, saturation reached. Three main themes identified that influenced vaccination: health consequences, ambiguity information societal motivation. Health consequences mainly concerned the effect offspring, unknown long-term effects vaccination. The advice Dutch institute Public Environment changed not vaccinating after release developed vaccine, routinely all data available United States America (USA). This change policy fuelled doubt confusion Arguments favor social perspective specific behaviour rules restrictions due pandemic. E.g. without people unable travel abroad having take test every time entering public place. Conclusion need clear, unambiguous concerning short- long-term, particularly decision-making process Additionally, needs be addressed. Besides aforementioned themes, general counselling should focus on misperceptions safety role misinformation which also important non-pregnant population. underlines importance including programs obtain targeted needs.

Language: Английский

Citations

2
Neurodevelopmental implications of COVID-19-induced gut microbiome dysbiosis in pregnant women DOI Creative Commons

Jacob D. Wilson,

Michaela Dworsky‐Fried,

Nafissa Ismail

et al.

Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 165, P. 104300 - 104300

Published: July 11, 2024

The global public health emergency of COVID-19 in January 2020 prompted a surge research focusing on the pathogenesis and clinical manifestations virus. While numerous reports have been published acute effects infection, review explores multifaceted long-term implications COVID-19, with particular focus severe maternal gut microbiome dysbiosis, neurodevelopmental disorders offspring. Severe infection has associated heightened immune system activation gastrointestinal symptoms. may also result dysbiosis compromised intestinal mucosal barrier, often referred to as 'leaky gut'. Increased permeability facilitates passage inflammatory cytokines, originating from inflamed mucosa gut, into bloodstream, thereby influencing fetal development during pregnancy potentially elevating risk such autism schizophrenia. current discusses role cytokine signaling molecules, microglia, synaptic pruning, highlighting their potential involvement following infection. Additionally, this addresses probiotic interventions mitigate responses offering avenues for future optimizing outcomes.

Language: Английский

Citations

1
Hepatitis B y su repercusión en el estado de salud de los neonatos por transmisión vertical en Latinoamérica DOI Creative Commons

Elisa Tatiana Fuentes-Sánchez,

Maria Odalis Franco-Macias,

Luisa de los Angeles González-Castillo

et al.

MQRInvestigar, Journal Year: 2024, Volume and Issue: 8(2), P. 4192 - 4215

Published: June 20, 2024

La enfermedad por el virus de la hepatitis B (VHB) es una infección transmisible aguda y crónica global que causa hepática importante, causada VHB infecta hígado inflamación hepatocelular, propósito del estudio fue analizar literatura existente sobre Hepatitis su repercusión en estado salud los neonatos, objetivo presente neonatos transmisión vertical Latinoamérica. metodologia empleada descriptivo, diseño documental, donde se emplearon un total 46 documentos para darle sustento a investigación. Entre resultados más relevantes encontró Brasil único país región presenta mayor porcentaje casos destacando con 19%, luego encuentra Perú 4,7% finalmente Chile 0,5%; las repercusiones destacables fueron, ictericia, retraso crecimiento, insuficiencia hepática; pruebas utilizadas cribado fueron serológicas como antígeno central B, anticuerpos IgG, IgM. Se concluyo destaca número dentro territorio latinoamericano; entre importantes encuentran crecimiento e diagnósticas son IgG

Citations

0
Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy DOI Creative Commons
Enrico Apa,

Nicole Carrie Tegmeyer,

Concetta D’Adamo

et al.

Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1237 - 1237

Published: Sept. 27, 2024

Studies about the effects of SARS-CoV-2 on pregnant women and children born to positive are controversial with regard possible inner ear-related damage but most them do not detect involvement this virus in auditory function. However, only a few studies long-term language development currently available because recent onset pandemic. The aim study was investigate impact infection perceptual expressive abilities emerging communication young children. To purpose, MacArthur-Bates Communicative Development Inventory-Words Gestures form (CDI-WG), administered parents. In total, 115 whose mother infected by during pregnancy were enrolled evaluated at Audiology Service Modena University Hospital. All underwent Otoacoustic Emissions (OAE) birth: 114/115 had "pass" result bilaterally, while 1 case unilateral "refer" result. Overall, 110/115 newborns (95.65%) audiological evaluation between 10-18 months age. 5/110 patients (3.6%), Pure Tone Average (PTA) equal 35 dB; one hearing threshold around 50 dB due bilateral effusive otitis media. A notable finding percentage tubal dysfunction both evaluations, within 2 age 12 Most revealed normal hearing. CDI-WG completed 56/115 families. rate below fifth percentile 8.9% for sentences understood, 12.5% words 5.4% produced. Concerning CDI-Gestures, (3.6%) percentile. structured follow-up association skills appears fundamental, particularly years maximum neuroplasticity. Long-term still necessary evaluate consequences

Language: Английский

Citations

0