Inflammatory Indices and MAFLD Prevalence in Hypertensive Patients: A Large-Scale Cross-Sectional Analysis from China

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1623 - 1638

Published: Feb. 1, 2025

Objective: Hypertension development and progression are largely influenced by inflammation, which plays a critical role activating the immune system causing damage to vascular endothelium. Metabolic dysfunction-associated fatty liver disease (MAFLD) is also associated with chronic low-grade drives via metabolic imbalances adipose tissue dysfunction. This study investigates relationship between inflammatory indices MAFLD in hypertensive patients assesses predictive accuracy of these for MAFLD. Methods: We performed cross-sectional analysis involving 34,303 from Chinese hospital-based registry. The diagnosis was established using dysfunction criteria alongside evidence hepatic steatosis confirmed through imaging. Complete blood counts were used calculate indices, including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), systemic response index (SIRI), immune-inflammation (SII), aggregate inflammation (AISI). To assess MAFLD, multivariable logistic regression adjustments potential confounders. diagnostic performance analyzed receiver operating characteristic (ROC) curves area under curve (AUC) calculations. Results: Patients exhibited significantly elevated levels all compared those without. After adjustment, each standard deviation increase AISI, SIRI, SII 74%, 62%, 58% increased odds respectively. AUC AISI 0.659, indicating moderate accuracy. AUCs SIRI 0.626 0.619, respectively, while NLR, PLR, MLR had lower 0.593, 0.558, 0.589, Conclusion: In patients, especially show strong association their utility risk stratification within clinical settings. Further research needed evaluate effectiveness markers management Keywords: metabolic-dysfunction-associated disease, hypertension,

Language: Английский

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Weight-adjusted waist index and its relationship with systemic inflammatory Index and metabolic indices in overweight and obese individuals: A cross-sectional study

Science Progress, Journal Year: 2025, Volume and Issue: 108(2)

Published: April 1, 2025

Background Obesity- characterized by excessive adiposity- is associated with various comorbidities, including metabolic, cardiovascular, and liver diseases. Chronic low-grade inflammation a key factor in complications obesity. This study aimed to investigate the associations between systemic inflammatory indices (SIIs) weight-adjusted waist index (WWI), alongside metabolic function biomarkers overweight obese individuals. Method cross-sectional included 350 or participants (body mass (BMI) ≥ 25 kg/m 2 ) from both genders. Weight, height, waist, hip, neck circumferences were measured BMI, WWI, ratios of height (WHtR) hip (WHR) estimated. Fasting blood samples taken assess SII as well parameters. Results In this study, males had significantly higher weight WC compared females, whereas mean level WWI (p < 0001) WHtR = 0.01) women greater than men. A significant correlation was observed (r 0.113, p 0.039), other HbA1c levels −0.117, 0.033) monocyte-to-lymphocyte ratio (MLR), fasting sugar (FBS) neutrophil-to-lymphocyte NLR 0.110, 0.041). quartiles showed differences aspartate aminotransferase AST 0.001), variations MLR also −0.112, 0.043). Conclusion Our results reveal strong correlations markers, SII, MLR, PLR, important obesity measures, parameters individuals

Language: Английский

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Prognostic value of lymphocyte-to-monocyte ratio in acute ischemic stroke: a systematic review and meta-analysis

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 7, 2025

The findings from studies exploring the prognostic relevance of lymphocyte-to-monocyte ratio (LMR) in individuals with acute ischemic stroke (AIS) have shown variability. We aimed to conduct a meta-analysis determine significance LMR this patient population. carried out utilizing information major databases, including PubMed, Embase, and Web Science until October 26, 2024. Effect sizes, represented as odds ratios (ORs) along their corresponding 95% confidence intervals (CI), were synthesized employing random-effects model Review Manager Version 5.4. To investigate possible sources variability, we conducted subgroup analyses. Additionally, publication bias was assessed through use funnel plot. Poor functional outcome at 3 months, indicated via modified Rankin Scale score ≥3, main outcome. A moderate severe stroke, determined by National Institutes Health Stroke ≥6, secondary Six trials totaling 1,225 included our analysis. In AIS patients, discovered significant correlation between lower poorer an OR 0.63, CI 0.49 0.80, p-value 0.0002. may be associated developing 0.89 (95% CI: 0.82-0.97; p = 0.008). analyses cutoff, association observed greater impairment 0.74 0.62-0.88; 0.0005) for ≥ 0.54 0.47-0.61; < 0.00001) 3. when country-stratified, Asian continued worse (OR 0.62, 0.50-0.77, 0.0001). This that factor clinical outcomes patients.

Language: Английский

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Advances of the multifaceted functions of PSTPIP2 in inflammatory diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

The complex interaction between the immune system and autoinflammatory disorders highlights centrality of autoimmune mechanisms in pathogenesis diseases. With exploration PSTPIP2, it has been discovered to play an inhibitory role diseases, suggesting its potential utility research treatment rheumatic This review outlines PSTPIP2 chronic multifocal osteomyelitis (CMO), rheumatoid arthritis (RA), synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, liver renal pressure ulcer sepsis diabetic obesity. include inhibiting IL-1β inflammatory responses, NF-κB, ERK phosphorylation etc., promoting Erβ, modulating polarization macrophage prevent summarized current findings offered perspectives on future directions, laying a foundation for applying

Language: Английский

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Association between galectin-3 and hepatosteatosis in a community-based cross-sectional study

Therapeutic Advances in Chronic Disease, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

Background: Hepatosteatosis is a common condition that can lead to cirrhosis and liver cancer. Galectin-3 (GAL-3) has been implicated in fibrosis inflammation. Objectives: The purpose of this study was investigate the association between GAL-3 hepatosteatosis. Design: This retrospective secondary analysis data from community health screening program. Methods: A total 766 participants were included final analysis. diagnosed using ultrasonography, levels measured enzyme-linked immunosorbent assay. Logistic regression used examine presence hepatosteatosis, adjusting for age, sex, other potential confounding factors. Results: prevalence moderate-to-severe hepatosteatosis population 31.5%. with had significantly higher mean level compared those without (16.6 ± 7.3 vs 13.5 ng/ml; p < 0.001). After body mass index, factors, associated an increased risk (adjusted odds ratio (aOR) 1.24, 95% confidence interval (CI) 1.05–1.46, = 0.010). coexistence alanine transaminase/aspartate transaminase >1 >14.4 ng/ml (aOR 3.37, CI: 1.90–5.99, Conclusion: Our findings suggest independent known cardiometabolic

Language: Английский

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Cardiometabolic Risk in Non-Diabetic MAFLD Patients: Insights from the Triglyceride–Glucose, Plasma Atherogenic, and Cardiometabolic Index

Archives of Medical Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

The objective of our study was to examine the correlation between hepatosteatosis and triglyceride-glucose index (TyG), plasma atherogenic (PAI), cardiometabolic (CMI) in nondiabetic patients. We also aimed assess usefulness these indices evaluating risk metabolic dysfunction-associated steatotic liver disease (MAFLD). This retrospective cross-sectional included 695 individuals who did not have diabetes, with an average age 39.8 ±11.3 years. A total 595 individuals, comprising 359 women 236 men, were diagnosed MAFLD. control group consisted 100 All subjects underwent transabdominal ultrasonography, anthropometric measurements, blood analyses. groups assessed based on TyG index, PAI, CMI. TyG, CMI greater patients MAFLD than those without a cutoff point 8.47, excluded significant simple steatosis sensitivity 65.3% specificity 66.0%. PAI values 0.39 1.40, sensitivities 66.6% 70.1% specificities 67.0% 70.1%, respectively. independently associated (OR = 2.21, 95% CI: 1.339-3.665). presence normal BMI waist circumference indicates that variables alone do provide enough evidence for diagnosis Hence, it is advisable incorporate into regular clinical practice obtain more precise thorough evaluation risk.

Language: Английский

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