Magnetic microscale polymeric nanocomposites in drug delivery: advances and challenges DOI Creative Commons
Kejing Shi, Ali Nokhodchi, Taravat Ghafourian

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: unknown, P. 104276 - 104276

Published: Dec. 1, 2024

Magnetic polymeric nanocomposites are a modern class of materials in which magnetic nanoparticles embedded matrix. This combination responsiveness and tuneable properties bestows versatility on this polymer nanocomposite material, has potentially broad applications drug delivery, imaging, environmental remediation beyond. review covers the uses discussing micelles, liposomes, hydrogels, sponges, mesoporous silica nanoparticles, microrobots, elastomers scaffolds. The focus is role that might be played by as an interface between domains establishment new generation advanced materials.

Language: Английский

Metal–organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications DOI Creative Commons
Doaa S. R. Khafaga,

Manar T. El-Morsy,

Habiba Faried

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(41), P. 30201 - 30229

Published: Jan. 1, 2024

Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design specific features such surface area pore size, encapsulation within not only improves their stability solubility but also allows controlled release kinetics, which therapeutic efficacy minimizes adverse effects. Furthermore, it discusses challenges potential advantages MOF-based delivery, MOF stability, biocompatibility, scale-up production. With further advancements in synthesis, functionalization techniques, understanding interactions using biological systems, can significant promise expanding medicine improving patient outcomes.

Language: Английский

Citations

18
Comparison of In Vitro and In Vivo Biological Screening of Nano‐Palladium (II) and Platinum (II)‐Based Compounds With DFT and Molecular Docking Study DOI Open Access
Safaa S. Hassan,

Wafaa M. Hosny,

Mohamed Ali Aboutabl

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

ABSTRACT Within the current challenges in medicinal chemistry, creation of novel and improved therapeutic agents stands out. 2‐Cyano‐3‐(thiophen‐2‐yl)prop‐2‐enethioamide (CTPTA) ligand was complexed with palladium (II) platinum ions within nanoscale molecular formula [M (CTPTA)Cl 2 ]. H O. The CTPTA its complexes were characterized by elemental analysis, UV–Vis spectra, FTIR, mass TGA, magnetic measurement, molar conductance technique. Analysis a scanning electron microscope (SEM) revealed that nanostructure dimension both is predominantly between 10 30 nm. functions as bidentate ligand, utilizing thione sulfur, cyanide nitrogen atoms. Density functional theory employed to analyze geometric structure properties complexes. Natural population (NPA) Mulliken (MPA) methods used calculate charge distribution. cytotoxic impact results all compounds on human liver cancer (HepG2) cell line satisfactory. also tested against gram‐negative gram‐positive bacteria vitro. findings docking study supported cytotoxicity antibacterial effects. antioxidant anti‐inflammation activities synthesized had great spectrum activity. preclinical pharmacokinetic studies albino rats newly studied achieved excellent antitumor results. This clear investigated parameters, especially amelioration AFP levels, weight, oxidative stress, lobular hepatic architecture injury.

Language: Английский

Citations

6
Green chemistry: Modern therapies using nanocarriers for treating rare brain cancer metastasis from colon cancer DOI Creative Commons
Doaa S. R. Khafaga, Ghazala Muteeb,

Darin W Aswa

et al.

SLAS DISCOVERY, Journal Year: 2025, Volume and Issue: unknown, P. 100213 - 100213

Published: Jan. 1, 2025

Brain metastasis (BM) from colon cancer is associated with a poor prognosis and restricted treatment alternatives, largely due to issues related blood-brain barrier (BBB) permeability the negative effects of standard chemotherapy. Nanotechnology improves efficacy by enabling targeted controlled drug delivery. This review article evaluates potential nanotechnology-based therapies for treating BM, emphasizing their capacity cross BBB, diminish metastatic growth, enhance overall survival rates. A multiple studies evaluated nanoparticles (NPs) as carriers chemotherapy, focusing on parameters including particle size, surface charge, drug-loading capacity. The study also reviewed that examined BBB penetration, in vitro tumor accumulation, vivo growth inhibition. In findings indicated NPs accumulate more efficiently BM tissue than healthy brain show significant penetration. vivo, nanotherapy markedly inhibited prolonged relative conventional chemotherapy or control treatments while exhibiting reduced side effects. Recent demonstrated plant extracts can effectively safely synthesize nanomaterials, positioning them viable environmentally friendly precursor nanomaterial production. Nanotechnology-based demonstrate minimizing systemic toxicity, enhancing therapeutic efficacy, facilitating Further research required confirm these implement clinical practice.

Language: Английский

Citations

0
Investigation of synergistic effects of silver nanoparticles with sorafenib on in vitro prostate and head and neck cancer models DOI
Murat Arslan, Elanur Aydın Karataş

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: April 24, 2025

Prostate cancer is one of the most common cancers in men and hypopharyngeal a rare aggressive malignant cancer. Since conventional treatments have side effects, current studies are directed towards finding innovative approaches diagnosis treatment In recent years, research has focussed on anticancer properties silver nanoparticles (AgNPs). The synergistic effects AgNPs sorafenib been studied, however, their impacts PC3 FaDu cells not studied yet. this study, were applied individually together to both cell types, examined at cellular molecular levels. Cell viability was measured by CVDK-8 assay. Apoptosis colorimetrically changes Caspase-3 levels identified with western blot analysis. individual groups decreased concentration-dependent cells. AgNPs-Sorafenib combination more effective inhibiting compared According Western analysis, significant change apoptosis observed cells, while group. findings study will provide new perspectives nanocarrier drug systems.

Language: Английский

Citations

0
Anti-cancer activity and optoelectronic properties via DFT calculations of rare-earth dually doped wurtzite-type ZnO nano-systems DOI
Y. Slimani, S. Çalışkan, Firdos Alam Khan

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 40, P. 101348 - 101348

Published: Sept. 26, 2024

Language: Английский

Citations

1
Magnetic microscale polymeric nanocomposites in drug delivery: advances and challenges DOI Creative Commons
Kejing Shi, Ali Nokhodchi, Taravat Ghafourian

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: unknown, P. 104276 - 104276

Published: Dec. 1, 2024

Magnetic polymeric nanocomposites are a modern class of materials in which magnetic nanoparticles embedded matrix. This combination responsiveness and tuneable properties bestows versatility on this polymer nanocomposite material, has potentially broad applications drug delivery, imaging, environmental remediation beyond. review covers the uses discussing micelles, liposomes, hydrogels, sponges, mesoporous silica nanoparticles, microrobots, elastomers scaffolds. The focus is role that might be played by as an interface between domains establishment new generation advanced materials.

Language: Английский

Citations

0