Immune response in cerebral ischemic injury: interaction and therapeutic potential DOI
Weijia Gao

New discovery., Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 20, 2024

Cerebral ischemia primarily results from vascular stenosis or blockage, which activates inflammatory cells and triggers an immune response. An excessive response can exacerbate the damage caused by cerebral ischemia. In this review, keywords “immune response” “cerebral ischemia” were entered into PubMed database, yielding 241 articles, of 141 included in analysis. Relevant literature 2021 to 2024 was summarized, classified, synthesized delineate advancements field. Consequently, exploring basic physiology responses brain injury, we found that microglia phagocytose dead neurons, thereby ameliorating ischemic injury. However, accumulate attack blood vessels nerve following ischemia, resulting additional damage. As a result, targeting CD8 T cells, astrocytes, superoxide dismutase (SOD), interleukin-10 (IL-10), tumor necrosis factor (TNF), NLRP3, NF-κB signaling pathway help mitigate Furthermore, specific mechanisms efficacy therapeutic drugs recent years analyzed, revealing their potential repair blood-brain barrier, endothelial while also reducing infarct size responses. Together, highlight particularly microglia, present new breakthroughs neuron phagocytosis, improvement responses, reduction These findings provide clinicians researchers with cutting-edge references for treatment strategies.

Language: Английский

Prediction and Recognition of Post-Stroke Cognitive Impairment DOI

诗雨 韩

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 333 - 338

Published: Jan. 1, 2025

Language: Английский

Citations

0
Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke DOI Creative Commons
Huaqiang Li, Xiaohua Ke, Bainian Feng

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Post-stroke cognitive impairment (PSCI) is a common complication following stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes heavy economic burden. There an urgent need to better understand the pathophysiology pathogenesis PSCI, as well identify markers can predict PSCI early in clinical stage, facilitating prevention, monitoring, treatment. Although mechanisms underlying are complex multifaceted, involving factors such atherosclerosis neuroinflammation, metabolic disorders play critical role. This article primarily reviews relationship between three major nutrients—sugar, fat, protein—and development dysfunction ischemic (IS). aims elucidate how these disturbances contribute post-stroke explore potential biomarkers for PSCI. We believe this review will offer new insights into identification, treatment, prognostic assessment

Language: Английский

Citations

0
Nuclear factor erythroid 2-related factor improves depression and cognitive dysfunction in rats with ischemic stroke by mediating wolfram syndrome 1 DOI

Guangxu Hu,

Hongjun Cao

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149572 - 149572

Published: March 1, 2025

Language: Английский

Citations

0
Predictive value of circulating inflammatory biomarkers for early-onset post-stroke cognitive impairment: a prospective cohort study DOI Creative Commons
Weiquan Huang,

Libin Liao,

Qian Liu

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

Introduction Stroke ranks as the second leading cause of mortality and third disability globally. Post-stroke cognitive impairment (PSCI) is a prevalent complication following acute ischemic stroke, imposing substantial burdens on patients, families, society. This study aimed to explore potential circulating immune-inflammatory markers predictors PSCI. Methods Conducted prospective observational cohort from June 2023 August 2024 at Affiliated Drum Tower Hospital, Medical School Nanjing University, it included patients experiencing their first stroke within 72 h symptom onset. Cognitive assessments were conducted 7 10 days post-stroke using Montreal Assessment (MoCA), with scores below 23 indicating Results A total 146 meeting inclusion criteria recruited, 71 exhibiting PSCI during phase stroke. Compared in no (PSNCI) group, those demonstrated significantly elevated peripheral blood neutrophil-to-lymphocyte ratio (NLR), globulin-to-lymphocyte (GLR), C-reactive protein-to-lymphocyte (CLR), while lymphocyte-to-monocyte (LMR) was notably reduced (all p < 0.05). Both univariate multivariate logistic regression analyses identified GLR independently associated After adjusting for common clinical variables, odds (OR) highest tertile compared lowest 6.20 (95% CI, 2.10–18.33; = 0.001). The optimal cutoff 18.22, sensitivity 62.0%, specificity 78.7%, an area under curve (AUC) 0.726. Conclusion indicates that levels onset are independent risk factor early-onset PSCI, even after clinically relevant variables.

Language: Английский

Citations

0
Immune response in cerebral ischemic injury: interaction and therapeutic potential DOI
Weijia Gao

New discovery., Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 20, 2024

Cerebral ischemia primarily results from vascular stenosis or blockage, which activates inflammatory cells and triggers an immune response. An excessive response can exacerbate the damage caused by cerebral ischemia. In this review, keywords “immune response” “cerebral ischemia” were entered into PubMed database, yielding 241 articles, of 141 included in analysis. Relevant literature 2021 to 2024 was summarized, classified, synthesized delineate advancements field. Consequently, exploring basic physiology responses brain injury, we found that microglia phagocytose dead neurons, thereby ameliorating ischemic injury. However, accumulate attack blood vessels nerve following ischemia, resulting additional damage. As a result, targeting CD8 T cells, astrocytes, superoxide dismutase (SOD), interleukin-10 (IL-10), tumor necrosis factor (TNF), NLRP3, NF-κB signaling pathway help mitigate Furthermore, specific mechanisms efficacy therapeutic drugs recent years analyzed, revealing their potential repair blood-brain barrier, endothelial while also reducing infarct size responses. Together, highlight particularly microglia, present new breakthroughs neuron phagocytosis, improvement responses, reduction These findings provide clinicians researchers with cutting-edge references for treatment strategies.

Language: Английский

Citations

0