Cited by Association between long-term exposure to air pollution and cause-specific mortality within five Italian longitudinal metropolitan studies

Microbiome and Brain-Gut Microbiota's Influence on Autism Pathogenesis DOI

Aman B. Upaganlawar, Nitu L. Wankhede, Mayur B. Kale

et al.

IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 99 - 132

Published: Jan. 31, 2025

Autism Spectrum Disorders (ASD) are neurodevelopmental conditions characterized by social communication challenges and repetitive behaviors. Emerging evidence suggests that gut microbiota, through the gut-brain axis, play a significant role in ASD pathogenesis. This complex network influences neurodevelopment modulating immune responses, producing neuroactive metabolites, maintaining barrier integrity. In individuals with ASD, specific microbial imbalances reduced diversity commonly observed, which linked to these pathophysiological processes. Genetic predispositions environmental factors, such as diet antibiotic use, further affect microbiota composition, potentially exacerbating imbalances. Therapeutic strategies targeting including probiotics, prebiotics, dietary modifications, fecal transplantation, have shown potential alleviating symptoms. chapter provides comprehensive overview of current understanding microbiota's ASD.

Language: Английский

Citations

CRISPR/Cas9-Based therapeutics as a promising strategy for management of Alzheimer’s disease: progress and prospects DOI

Mohamad Sultan Khan,

Nousheen Qureshi,

Rehan Khan

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

CRISPR/Cas9 technology has revolutionized genetic and biomedical research in recent years. It enables editing modulation of gene function with an unparalleled precision effectiveness. Among the various applications prospects this technology, opportunities it offers unraveling molecular underpinnings a myriad central nervous system diseases, including neurodegenerative disorders, psychiatric conditions, developmental abnormalities, are unprecedented. In review, we highlight CRISPR/Cas9-based therapeutics as promising strategy for management Alzheimer's disease transformative impact on AD research. Further, emphasize role generating accurate models identification novel therapeutic targets, besides CRISPR-based therapies aimed at correcting AD-associated mutations modulating processes. Furthermore, delivery systems reviewed potential non-viral nanotechnology-based carriers overcoming critical limitations effective is discussed. Overall, review highlights promise intricate processes underlying development AD, discusses its limitations, ethical concerns several challenges efficient across BBB, ensuring specificity, avoiding off-target effects. This article can be helpful better understanding based approaches way forward utilizing enormous targeted, gene-specific treatments that could change trajectory debilitating incurable illness.

Language: Английский

Citations

Connecting the dots: environmental pollution and Autism Spectrum Disorder DOI

Bidisha Bhattacharya, Devinder Toor, Mallika Chatterjee

et al.

Reviews on Environmental Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social communication and repetitive behavior. While the exact etiology of ASD remains elusive, researchers have increasingly turned their attention to role environmental factors its development. Among these factors, pollution has emerged as potential contributor rising prevalence cases worldwide. This review delves into growing body scientific evidence suggesting significant association between risk ASD. It explores that been implicated, including air pollution, water contaminants, heavy metals, pesticides, endocrine-disrupting chemicals. The detrimental impact pollutants on developing brain, particularly during critical periods gestation early childhood discussed. will provide insights possible mechanisms which various may influence pathways underlying Additionally, interplay genetic susceptibility exposure explored better understand multifactorial nature causation. Considering alarming increase ubiquity pollutants, this emphasizes urgent need for further investigation adoption comprehensive preventive measures.

Language: Английский

Citations

Harnessing Virtual Reality: Improving Social Skills in Adults with Autism Spectrum Disorder DOI

Andrea Calderone,

Angela Militi,

Dèsiréè Latella

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(21), P. 6435 - 6435

Published: Oct. 27, 2024

Background and Objectives: Autism Spectrum Disorder (ASD) involves challenges in social communication daily functioning. Emerging research highlights that virtual reality (VR) interventions can significantly improve skills adults with ASD by providing immersive, controlled practice environments. This systematic review will assess the effectiveness of VR-based for improving ASD. Materials Methods: Studies were identified from an online search PubMed, Web Science, Cochrane Library, Embase databases without any time range. was registered on Open OSF (n) P4SM5. Results: Recent studies show VR enhance job interview skills, abilities, practical tasks ASD, improvements confidence, understanding, everyday skills. has been shown to be user-friendly effective adaptable training experiences. Conclusions: The VR’s promising role functioning It emphasizes need broader studies, standardized interventions, exploration integration other therapies long-term address comorbidities like anxiety depression.

Language: Английский

Citations

Association between Autism Spectrum Disorder and Environmental Quality in the United States DOI

Jianyong Wu, Alexander C. McLain,

Paul A. Rosile

et al.

ISPRS International Journal of Geo-Information, Journal Year: 2024, Volume and Issue: 13(9), P. 308 - 308

Published: Aug. 29, 2024

Autism spectrum disorder (ASD) has become an emerging public health problem. The impact of multiple environmental factors on the prevalence ASD remains unclear. This study examined association between and quality index (EQI), indicator cumulative in five major domains, including air, water, land, built sociodemographic variables United States. results from Poisson regression models show that a positive with overall EQI risk ratio (RR) 1.03 95% confidence intervals (CI) 1.01–1.06, indicating children counties poor might have higher ASD. Additionally, air (RR = 1.04, CI: 1.01–1.06). These associations varied different rural–urban groups climate regions. provided evidence for adverse effects quality, particularly pollutants, children’s neurodevelopment.

Language: Английский

Citations

Association between long-term exposure to air pollution and cause-specific mortality within five Italian longitudinal metropolitan studies DOI

Federica Nobile, Nicola Caranci, Elena Strippoli

et al.

Atmospheric Environment, Journal Year: 2024, Volume and Issue: unknown, P. 120873 - 120873

Published: Oct. 1, 2024

Language: Английский

Citations