Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway DOI Creative Commons
Reham H. Mohyeldin,

Ehab E. Sharata,

Michael Atef Fawzy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

Language: Английский

Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review DOI Creative Commons
Rudolf Vrabec, Pavel Drašar, Lubomı́r Opletal

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Language: Английский

Citations

0
Protective effects of liensinine against acetaminophen-induced liver injury through relieving inflammation, oxidative stress, and apoptosis DOI Creative Commons

Yaran Suo,

Shuyu Li, Chunjin Fu

et al.

Science of Traditional Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract Background Acetaminophen (APAP)-induced hepatotoxicity has attracted considerable attention in clinical settings due to the limited treatment options available. Liensinine stands out as a key alkaloid known for its pharmaceutical activities. However, role of liensinine mitigating APAP-induced liver injury remains unclear. Objective The aim study was explore protective effects against injury. Methods C57BL/6 male mice were treated with dose 200 mg/kg N-acetylcysteine or varying doses (10 20 mg/kg) seven consecutive days. APAP (400 mg/kg, i.g .) then administered induce damage 12 hours. Blood samples and hepatic tissues collected further analysis. Liver enzyme levels histopathological analysis employed assess RNA-seq conducted evaluate dynamic changes gene expression. Biochemical assays used measure oxidative stress inflammation, while TUNEL assay performed hepatocyte apoptosis. Results results demonstrated that administration mitigated serum tissue resulting from overdose. Transcriptome revealed significant coordinated genes related peroxisome proliferator-activated receptor signaling pathway, mitogen-activated protein kinase apoptosis pathway response hepatotoxicity. expression alterations within these three pathways, associated stress, cell apoptosis, reversed by liensinine, indicating potential alleviating through multiple pathways. This suggests diverse therapeutic including inflammation suppression, reduction, inhibition. Indeed, pretreatment effectively reduced inflammatory cytokines, indicators, apoptotic cells induced APAP. Conclusions mitigates multifaceted providing anti-inflammatory, antioxidant, anti-apoptotic benefits.

Language: Английский

Citations

0
Mechanisms of sepsis-induced acute liver injury: a comprehensive review DOI Creative Commons

Yongjing Guo,

Wanxu Guo,

Huimin Chen

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 21, 2025

Sepsis is a severe, often life-threatening form of organ dysfunction that arises from an inappropriately regulated host response to infectious pathogen exposure. As the largest gland in body, liver serves as regulatory hub for metabolic, immune, and detoxification activity. It also early sepsis target such hepatic observed 34-46% patients with sepsis. The precise mechanisms give rise sepsis-induced injury, however, remain incompletely understood. Based on research conducted date, dysregulated systemic inflammation, microbial translocation, microcirculatory abnormalities, cell death, metabolic dysfunction, inflammation may all contribute damage can arise context septicemia. This review was developed provide overview summarizing potential underlying informing selection targets therapeutic intervention providing framework alleviation patient symptoms improvement prognostic outcomes.

Language: Английский

Citations

0
Protective effects of vincamine against ethanol-induced gastric ulcer by attenuation of IL-6, IL-1β, and TNF-α mRNA expression levels in the gastric mucosa of BALB/c mice DOI

Imam H,

Arham Shabbir,

Anum Jamil

et al.

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: March 5, 2025

Language: Английский

Citations

0
Levomilnacipran alleviates cyclophosphamide-induced hepatic dysfunction in male Wistar albino rats; emerging role of α-Klotho/TLR4/p38-MAPK/NF-κB p65 and caspase-3-driven apoptosis trajectories DOI

Ehab E. Sharata,

Mina Ezzat Attya,

Marwa M. Khalaf

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114384 - 114384

Published: March 8, 2025

Language: Английский

Citations

0
Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, Caspase-3-driven apoptosis, and Klotho protein expression DOI
Remon Roshdy Rofaeil,

Ehab E. Sharata,

Mina Ezzat Attya

et al.

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115406 - 115406

Published: March 1, 2025

Language: Английский

Citations

0
Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway DOI Creative Commons
Reham H. Mohyeldin,

Ehab E. Sharata,

Michael Atef Fawzy

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 15, 2025

Language: Английский

Citations

0