Biocompatibility of Kaffir lime fruit juice powered ZnO nanoparticles in earthworm, Eudrilus eugeniae: A green biomimetic approach DOI Creative Commons

Sampath Paventhan,

P. Kavitha,

T. Balasubramanian

et al.

BioResources, Journal Year: 2024, Volume and Issue: 20(1), P. 1345 - 1364

Published: Dec. 11, 2024

ZnO nanoparticles were synthesized using the raw juice of Kaffir lime (Citrus hystrix) fruit bya simple and cost-effective green route its effects on earthworms, Eudrilus eugeniae, studied. The kaffir-lime powered (ZnO:KL) characterized by X-ray diffraction (XRD), UV-Vis-NIR spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission (TEM). filter paper method was adopted to test toxicity ZnO:KL. Earthworms (species eugeniae) exposed 100 1000 mg/L ZnO:KL in one-step order. During study period (up 48 h), no mortality found any treatment group. In histological observation, damage epidermal layer earthworm’s skin treated up 800 mg/L, whereas slight observed only 900 earthworms. GC-MS spectrum kaffir revealed 22 bioactive compounds. predominantly identified compounds vitamin C citric acid subjected molecular docking reveal their binding affinity with collagen – a structural protein providing strength flexibility body. Vitamin bind favorable orientation -4.44 kcal/mol -4.97 kcal/mol, respectively. Since are capable influencing biosynthesis collagen, they could prevent damage. sum, lime-powered nanomaterial is less toxic earthworm when compared bare ZnO.

Language: Английский

Green synthesis of ZnO nanoparticles from the extract of Cymbopogon olivieri and investigation of their antimicrobial and anticancer effects DOI Creative Commons

Fahimeh Golzarnezhad,

Maryam Allahdou,

Leila Mehravaran

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(3)

Published: March 3, 2025

Language: Английский

Citations

1
Bio-fabrication of multifunctional CuO-ZnO nanocomposites for improved biomedical and industrial wastewater purification by experimental and molecular docking computational investigation DOI

M. Dhanalakshmi,

Venkatramana Losetty

Journal of Water Process Engineering, Journal Year: 2025, Volume and Issue: 70, P. 106933 - 106933

Published: Jan. 5, 2025

Language: Английский

Citations

0
Eco-Inspired Cu-Zn Bimetallic Nanoparticles for Enhanced Water Purification Technologies DOI

Naveen Kumar Dabbeta,

Kante Mamtha,

K. Ramya

et al.

Materials chemistry and physics., Journal Year: 2025, Volume and Issue: unknown, P. 100013 - 100013

Published: Feb. 1, 2025

Language: Английский

Citations

0
Evaluating catalytic and antibacterial properties of composite hydrogel based on biomimetically synthesized CeO2 nanoparticles anchored onto microcrystalline cellulose/reduced graphene oxide DOI

Saima Sohni,

Abdullah Abdullah,

Esraa M. Bakhsh

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141749 - 141749

Published: March 4, 2025

Language: Английский

Citations

0
Unveiling the potency of ZnO and CuO nanocomposites in combating hepatocellular carcinoma by inducing cell death and suppressing migration DOI Creative Commons
Rasha Mahmoud Allam,

Nesma M. E. Abo El-Nasr,

Marawan A. Elbaset

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 3, 2025

Abstract Human hepatocellular carcinoma (HCC) is recognized as one of the leading causes death globally and resistant to several anticancer drugs. As a result, it critical identify more effective druggable therapies. Metal oxide nanoparticles (MO-NPs), especially nanocomposites, have recently received much attention owing their potential applications in cancer therapy. In this study, we synthesized zinc (ZnO) copper (CuO) nanocomposites different ratios (N1, N2, N3). We evaluated cytotoxicity against two HCC cell lines (HepG2 HuH-7) normal liver (BNL), compared with Sorafenib standard Then, investigated underlying mechanisms action employing flow cytometry, migration assay, western blot. The results showed that nanocomposite an equal ratio both ZnO CuO-NPs (N1) exhibited highest cytotoxic activity on HuH7 line while exerting no detrimental impact rat epithelial cells. Further investigation into toxicity N1 revealed three modalities induced (apoptotic, necrotic, autophagic) along S- G2/M cycle arrest, suggesting mitotic catastrophe. Furthermore, displayed potent anti-migratory activity, surpassing sorafenib, upregulated protein level autophagy marker beclin-1, downregulated EMT-marker vimentin. Overall, our findings combining ZnO-NPs intriguing combating HCC, providing prospective guidance for evolving therapy bimetallic NPs.

Language: Английский

Citations

0
Characterization and investigating the potential therapeutic effects of phyto-assisted CuO and Zn-doped CuO nanoparticles from Calophyllum apetalum (Willd) leaf extract DOI
Vrushali Manoj Hadkar, Chinnadurai Immanuel Selvaraj

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 104, P. 106530 - 106530

Published: Dec. 13, 2024

Language: Английский

Citations

2
Biocompatibility of Kaffir lime fruit juice powered ZnO nanoparticles in earthworm, Eudrilus eugeniae: A green biomimetic approach DOI Creative Commons

Sampath Paventhan,

P. Kavitha,

T. Balasubramanian

et al.

BioResources, Journal Year: 2024, Volume and Issue: 20(1), P. 1345 - 1364

Published: Dec. 11, 2024

ZnO nanoparticles were synthesized using the raw juice of Kaffir lime (Citrus hystrix) fruit bya simple and cost-effective green route its effects on earthworms, Eudrilus eugeniae, studied. The kaffir-lime powered (ZnO:KL) characterized by X-ray diffraction (XRD), UV-Vis-NIR spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission (TEM). filter paper method was adopted to test toxicity ZnO:KL. Earthworms (species eugeniae) exposed 100 1000 mg/L ZnO:KL in one-step order. During study period (up 48 h), no mortality found any treatment group. In histological observation, damage epidermal layer earthworm’s skin treated up 800 mg/L, whereas slight observed only 900 earthworms. GC-MS spectrum kaffir revealed 22 bioactive compounds. predominantly identified compounds vitamin C citric acid subjected molecular docking reveal their binding affinity with collagen – a structural protein providing strength flexibility body. Vitamin bind favorable orientation -4.44 kcal/mol -4.97 kcal/mol, respectively. Since are capable influencing biosynthesis collagen, they could prevent damage. sum, lime-powered nanomaterial is less toxic earthworm when compared bare ZnO.

Language: Английский

Citations

0