Wnt5a exacerbates pathological bone features and trabecular bone loss in curdlan-injected SKG mice via osteoclast activation

BMB Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Many studies on osteoblasts have suggested that Wnt5a plays a crucial role in excessive osteoblast activity, which is responsible for ectopic new bone formation, but research osteoclasts ankylosing spondylitis (AS) remains relatively limited.This study aimed to explore whether influences osteoclastmediated resorption curdlan-injected SKG mice, model mimics AS.Compared the Vehicle group, treatment group exhibited statistically higher clinical arthritis scores and increased hindpaw thickness values.Microcomputed tomography (microCT) analysis of hindpaws revealed significant increase inflamed density Wnt5a-treated compared group.Histological examination also showed pronounced inflammation structural damage marrow ankles group.Intriguingly, microCT femur trabecular loss was markedly observed group.Both number TRAP-positive their activity were greater group.Serum markers resorption, not significantly elevated group.Notably, promotion osteoclast differentiation by inhibited following with anti-Wnt5a.These findings suggest targeting could be promising strategy mitigating pathological features AS modulating activity.

Language: Английский

Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 4, 2025

Language: Английский