Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome DOI Creative Commons
Éllen Francine Rodrigues, Flávia Alves Verza, Felipe Garcia Nishimura

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 23(1), P. 8 - 8

Published: Dec. 26, 2024

Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through domains. have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles the physiological developmental processes of organisms. Moreover, their diversity enables biotechnological exploration as biomarkers, biosensors, drug-delivery platforms, lead molecules for anticancer, antidiabetic, antimicrobial drugs. from Rhodophytes (red seaweed) been extensively reported characterized unique structures, carbohydrate-binding specificities, important activities. The increasing number sequenced Rhodophyte genomes offers opportunity further study this rich source lectins, potentially uncovering new ones with properties significantly different terrestrial plant counterparts, thus opening applications. We compiled literature data conducted an in-depth analysis phycolectomes Rhodophyta available NCBI datasets. Using Hidden Markov Models capable identifying lectin-type domains, we at least six types lectin domains present Rhodophytes, demonstrating potential lectins. This review integrates a computational phycolectome existing information on red algae lectins potential.

Language: Английский

Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome DOI Creative Commons
Éllen Francine Rodrigues, Flávia Alves Verza, Felipe Garcia Nishimura

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 23(1), P. 8 - 8

Published: Dec. 26, 2024

Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through domains. have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles the physiological developmental processes of organisms. Moreover, their diversity enables biotechnological exploration as biomarkers, biosensors, drug-delivery platforms, lead molecules for anticancer, antidiabetic, antimicrobial drugs. from Rhodophytes (red seaweed) been extensively reported characterized unique structures, carbohydrate-binding specificities, important activities. The increasing number sequenced Rhodophyte genomes offers opportunity further study this rich source lectins, potentially uncovering new ones with properties significantly different terrestrial plant counterparts, thus opening applications. We compiled literature data conducted an in-depth analysis phycolectomes Rhodophyta available NCBI datasets. Using Hidden Markov Models capable identifying lectin-type domains, we at least six types lectin domains present Rhodophytes, demonstrating potential lectins. This review integrates a computational phycolectome existing information on red algae lectins potential.

Language: Английский

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