Rumen microbiota regulates IMF deposition in Xizang sheep by activating the PPARγ transcription factor: a rumen-muscle axis perspective DOI Creative Commons
Cheng Pan, Junru Pan,

Yangzong Zhaxi

et al.

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT The interaction between microbiota and muscle by the rumen-muscle axis its impact on sheep meat flavor has received little attention. This study selected Xizang under summer autumn grazing conditions as models for different rumen bacteria intramuscular fat (IMF) to attempt address current research gap. Specifically, deposition characteristics of IMF expression lipid metabolism genes in were determined; 16S rDNA sequencing technology gas chromatography used metabolic products, short-chain fatty acids (SCFAs); RNA was identify transcriptome epithelium. Based above results, we proposed hypothesis that is regulated microbiota-rumen-muscle axis. SCFAs produced are absorbed epithelium regulation solute carrier family ( SLC ). can directly reach tissue through circulatory system then activate peroxisome proliferator-activated receptor Gamma PPARγ ) gene synthesis carnitine palmitoyltransferase II CPT2 ), acid synthase FAS patatin-like phospholipase domain-containing 2 PNPLA2 stearoyl-CoA desaturase 1 SCD1 correspondingly upregulated, promoting thus affecting flavor. introduces theory into ruminant animal food, comprehensively elucidating regulatory mechanism meat. IMPORTANCE Our employed a multi-omics approach reveal how regulate activation transcription factor. Importantly, developing with varying microbial communities profiles, established critical role determining finding suggests modulating composition community could serve strategy improve ruminant-derived food products. These insights provide valuable understanding complex interactions mutton flavor, offering new approaches this field.

Language: Английский

Rumen microbiota regulates IMF deposition in Xizang sheep by activating the PPARγ transcription factor: a rumen-muscle axis perspective DOI Creative Commons
Cheng Pan, Junru Pan,

Yangzong Zhaxi

et al.

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT The interaction between microbiota and muscle by the rumen-muscle axis its impact on sheep meat flavor has received little attention. This study selected Xizang under summer autumn grazing conditions as models for different rumen bacteria intramuscular fat (IMF) to attempt address current research gap. Specifically, deposition characteristics of IMF expression lipid metabolism genes in were determined; 16S rDNA sequencing technology gas chromatography used metabolic products, short-chain fatty acids (SCFAs); RNA was identify transcriptome epithelium. Based above results, we proposed hypothesis that is regulated microbiota-rumen-muscle axis. SCFAs produced are absorbed epithelium regulation solute carrier family ( SLC ). can directly reach tissue through circulatory system then activate peroxisome proliferator-activated receptor Gamma PPARγ ) gene synthesis carnitine palmitoyltransferase II CPT2 ), acid synthase FAS patatin-like phospholipase domain-containing 2 PNPLA2 stearoyl-CoA desaturase 1 SCD1 correspondingly upregulated, promoting thus affecting flavor. introduces theory into ruminant animal food, comprehensively elucidating regulatory mechanism meat. IMPORTANCE Our employed a multi-omics approach reveal how regulate activation transcription factor. Importantly, developing with varying microbial communities profiles, established critical role determining finding suggests modulating composition community could serve strategy improve ruminant-derived food products. These insights provide valuable understanding complex interactions mutton flavor, offering new approaches this field.

Language: Английский

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