Circular RNAs in cancer DOI Creative Commons
Yang Guo, Qiang Huang,

Heng Yu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as significant focus in research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles diverse physiological and pathological processes, functioning through mechanisms such miRNAs or proteins sponging, regulation splicing gene expression, serving translation templates, particularly the context various cancers. The hallmarks cancer comprise functional capabilities acquired during carcinogenesis tumor progression, providing conceptual framework that elucidates nature malignant transformation. Although numerous studies have elucidated role circRNAs cancers, their functions development chemoradiotherapy resistance remain unexplored clinical applications circRNA‐based translational therapeutics are still infancy. This review provides comprehensive overview circRNAs, covering biogenesis, unique characteristics, functions, turnover mechanisms. We also summarize involvement relevance biomarkers therapeutic targets, especially thyroid (TC). Considering potential fascination therapeutics, “Ying‐Yang” dynamic regulations TC warrant vastly dedicated investigations.

Language: Английский

SHP2 inhibition and adjuvant therapy synergistically target KIT‐mutant GISTs via ERK1/2‐regulated GSK3β/cyclin D1 pathway DOI Creative Commons

Chunxiao He,

Jiaying Yu,

Shuang Mao

et al.

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

Language: Английский

Citations

1
Circular RNAs in cancer DOI Creative Commons
Yang Guo, Qiang Huang,

Heng Yu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract Circular RNA (circRNA), a subtype of noncoding RNA, has emerged as significant focus in research due to its distinctive covalently closed loop structure. CircRNAs play pivotal roles diverse physiological and pathological processes, functioning through mechanisms such miRNAs or proteins sponging, regulation splicing gene expression, serving translation templates, particularly the context various cancers. The hallmarks cancer comprise functional capabilities acquired during carcinogenesis tumor progression, providing conceptual framework that elucidates nature malignant transformation. Although numerous studies have elucidated role circRNAs cancers, their functions development chemoradiotherapy resistance remain unexplored clinical applications circRNA‐based translational therapeutics are still infancy. This review provides comprehensive overview circRNAs, covering biogenesis, unique characteristics, functions, turnover mechanisms. We also summarize involvement relevance biomarkers therapeutic targets, especially thyroid (TC). Considering potential fascination therapeutics, “Ying‐Yang” dynamic regulations TC warrant vastly dedicated investigations.

Language: Английский

Citations

0