SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil DOI Creative Commons
Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhães de Oliveira

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 207 - 207

Published: Jan. 31, 2025

Understanding perinatal health outcomes following SARS-CoV-2 infection during pregnancy necessitates large-scale studies of mother-infant dyads. Hospital-based pregnant women and their neonates provide valuable insights within the field research. The aim this study was to evaluate effect on maternal among hospitalized in Rio de Janeiro COVID-19 pandemic. consisted a time-to-event analysis hospital-based cohort 1185 ≥ 16 years infants from May 2020 March 2022. Pregnant were classified as infected if they had SARS CoV-2 positive RT-PCR or rapid antigen test. An exploratory qualitative variables conducted with calculation absolute relative frequencies 95% confidence intervals. Survival functions estimated by Kaplan-Meier method, Cox proportional hazards model employed interpret effects time adverse outcomes, adjusted for vaccination, comorbidity, gestational trimester. A total 21% (249/1185) SARS-CoV-2, median age 26 (range: 16-47). Cesarean section deliveries performed 57% (135/237) CoV-2+ participants vs. 43% (391/914) uninfected participants, p < 0.001. Intensive care unit admission and/or death occurred 68 (5.7%), 44 249 (17.7%) 24 936 (2.5%). All 21 who died unvaccinated against COVID-19. Women at greater risk (crude HR: 5.93, CI: 3.58-9.84; 5.47, 3.16-9.48) than women. vertical transmission observed 6 169 (3.6%) tested neonates. Preterm more frequently patients testing (30.7% 23.6). In survival analysis, no prematurity (HR: 0.92, 0.68-1.23) including fetal distress 1.29, 0.82-2.05), stillbirth 1.07, 0.48-2.38), neonatal 0.96, 0.35-2.67), even after adjusting trimester, periods time. due highlights need adequate preventive measures, particularly prenatal postpartum periods.

Language: Английский

SARS-CoV-2 Infection and Adverse Maternal and Perinatal Outcomes: Time-to-Event Analysis of a Hospital-Based Cohort Study of Pregnant Women in Rio de Janeiro, Brazil DOI Creative Commons
Michelle Brendolin, Mayumi Duarte Wakimoto, Raquel de Vasconcellos Carvalhães de Oliveira

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 207 - 207

Published: Jan. 31, 2025

Understanding perinatal health outcomes following SARS-CoV-2 infection during pregnancy necessitates large-scale studies of mother-infant dyads. Hospital-based pregnant women and their neonates provide valuable insights within the field research. The aim this study was to evaluate effect on maternal among hospitalized in Rio de Janeiro COVID-19 pandemic. consisted a time-to-event analysis hospital-based cohort 1185 ≥ 16 years infants from May 2020 March 2022. Pregnant were classified as infected if they had SARS CoV-2 positive RT-PCR or rapid antigen test. An exploratory qualitative variables conducted with calculation absolute relative frequencies 95% confidence intervals. Survival functions estimated by Kaplan-Meier method, Cox proportional hazards model employed interpret effects time adverse outcomes, adjusted for vaccination, comorbidity, gestational trimester. A total 21% (249/1185) SARS-CoV-2, median age 26 (range: 16-47). Cesarean section deliveries performed 57% (135/237) CoV-2+ participants vs. 43% (391/914) uninfected participants, p < 0.001. Intensive care unit admission and/or death occurred 68 (5.7%), 44 249 (17.7%) 24 936 (2.5%). All 21 who died unvaccinated against COVID-19. Women at greater risk (crude HR: 5.93, CI: 3.58-9.84; 5.47, 3.16-9.48) than women. vertical transmission observed 6 169 (3.6%) tested neonates. Preterm more frequently patients testing (30.7% 23.6). In survival analysis, no prematurity (HR: 0.92, 0.68-1.23) including fetal distress 1.29, 0.82-2.05), stillbirth 1.07, 0.48-2.38), neonatal 0.96, 0.35-2.67), even after adjusting trimester, periods time. due highlights need adequate preventive measures, particularly prenatal postpartum periods.

Language: Английский

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