Fish MicroRNA Responses to Thermal Stress: Insights and Implications for Aquaculture and Conservation Amid Global Warming DOI Creative Commons

Ting Lin,

Madhava Meegaskumbura

Animals, Journal Year: 2025, Volume and Issue: 15(5), P. 624 - 624

Published: Feb. 20, 2025

In the context of global warming, heat tolerance is becoming a crucial physiological trait influencing fish species’ distribution and survival. While our understanding stress has expanded from behavioral studies to transcriptomic analyses, knowledge at level still limited. Recently, highly conserved microRNAs (miRNAs) have provided new insights into molecular mechanisms in fish. This review systematically examines current research across three main reference databases elucidate universal responses miRNAs under stress. Our initial screening 569 articles identified 13 target papers for comprehensive analysis. Among these, least 214 differentially expressed (DEMs) were found, with 15 DEMs appearing two (12 upregulated downregulated). The recurrent analyzed using DIANA mirPath v.3 microT-CDS v5.0 database identify potential genes. results suggest that multiple various genes, forming complex network regulates glucose energy metabolism, maintains homeostasis, modulates inflammation immune responses. Significantly, miR-1, miR-122, let-7a, miR-30b consistently studies, indicating their relevance However, these should not be considered definitive biomarkers without further validation. Future focus on experimentally confirming regulatory roles through functional assays, conducting comparisons different species, performing validation studies. These miRNAs, could valuable monitoring wild health, enhancing aquaculture breeding, guiding conservation strategies. specific need clarification confirm reliability as thermal

Language: Английский

Fish MicroRNA Responses to Thermal Stress: Insights and Implications for Aquaculture and Conservation Amid Global Warming DOI Creative Commons

Ting Lin,

Madhava Meegaskumbura

Animals, Journal Year: 2025, Volume and Issue: 15(5), P. 624 - 624

Published: Feb. 20, 2025

In the context of global warming, heat tolerance is becoming a crucial physiological trait influencing fish species’ distribution and survival. While our understanding stress has expanded from behavioral studies to transcriptomic analyses, knowledge at level still limited. Recently, highly conserved microRNAs (miRNAs) have provided new insights into molecular mechanisms in fish. This review systematically examines current research across three main reference databases elucidate universal responses miRNAs under stress. Our initial screening 569 articles identified 13 target papers for comprehensive analysis. Among these, least 214 differentially expressed (DEMs) were found, with 15 DEMs appearing two (12 upregulated downregulated). The recurrent analyzed using DIANA mirPath v.3 microT-CDS v5.0 database identify potential genes. results suggest that multiple various genes, forming complex network regulates glucose energy metabolism, maintains homeostasis, modulates inflammation immune responses. Significantly, miR-1, miR-122, let-7a, miR-30b consistently studies, indicating their relevance However, these should not be considered definitive biomarkers without further validation. Future focus on experimentally confirming regulatory roles through functional assays, conducting comparisons different species, performing validation studies. These miRNAs, could valuable monitoring wild health, enhancing aquaculture breeding, guiding conservation strategies. specific need clarification confirm reliability as thermal

Language: Английский

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