Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair DOI Creative Commons

Jiahao Ren,

Xinzhe Chen, Tao Wang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 7, 2025

Cardiovascular diseases are the most lethal worldwide, of which myocardial infarction is leading cause death. After infarction, in order to ensure normal blood supply heart, remaining cardiomyocytes compensate for loss mainly by working at high capacity rather than proliferating produce new cardiomyocytes. This partly due extremely limited ability adult heart repair itself. A growing body research suggests that cardiac regenerative closely related metabolic shifts energy sources. Currently, a large number studies have focused on changes levels before and after proliferation window cardiomyocytes, so it crucial search relevant factors pathways regulate cell cycle cardiomyocyte progression. paper presents review role metabolism injury. It aims elucidate effects mammals point out directions regeneration clinical treatment infarction.

Language: Английский

Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair DOI Creative Commons

Jiahao Ren,

Xinzhe Chen, Tao Wang

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 7, 2025

Cardiovascular diseases are the most lethal worldwide, of which myocardial infarction is leading cause death. After infarction, in order to ensure normal blood supply heart, remaining cardiomyocytes compensate for loss mainly by working at high capacity rather than proliferating produce new cardiomyocytes. This partly due extremely limited ability adult heart repair itself. A growing body research suggests that cardiac regenerative closely related metabolic shifts energy sources. Currently, a large number studies have focused on changes levels before and after proliferation window cardiomyocytes, so it crucial search relevant factors pathways regulate cell cycle cardiomyocyte progression. paper presents review role metabolism injury. It aims elucidate effects mammals point out directions regeneration clinical treatment infarction.

Language: Английский

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