Interruptins Extracted from Cyclosorus terminans Protect Gut Pathologies Induced by High-Fat Diet in Rats DOI Open Access
Chanisa Thonusin, Kanokphong Suparan, Chanon Kunasol

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1387 - 1387

Published: April 20, 2025

Background/Objectives: The fern “Cyclosorus terminans” (C. terminans) or “Maiden Fern” contains interruptin A and B. This plant could attenuate obesity, insulin resistance, fatty liver in rats fed a high-fat/calorie diet. However, the benefits of C. terminans to gut remain unknown. We investigated protective effect extract against dysfunction exposed Methods: Male Wistar were assigned receive either (1) normal diet treated with vehicle, (2) (3) 100 mg per kg day (mg·kg−1·day−1) extract, (4) 200 mg·kg−1·day−1 extract. euthanized after 12 weeks treatment enable feces colon tissue collection. Results: Both reduced body weight (−10.49%; p = 0.030 −10.54%; 0.037, respectively) ameliorated inflammation, barrier disruption, changes short-chain acid levels, dysbiosis caused by Conclusions: attenuated an increase exerted prophylactic effects pathologies induced

Language: Английский

Unveiling the Mechanisms of Pain in Endometriosis: Comprehensive Analysis of Inflammatory Sensitization and Therapeutic Potential DOI Open Access

Yixiao Chen,

Tian Li

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1770 - 1770

Published: Feb. 19, 2025

Endometriosis is a complicated, estrogen-dependent gynecological condition with high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women's physical and mental health exacerbates socioeconomic burden. However, specific mechanisms behind occurrence endometriosis-related pain remain unclear. It currently believed that endometriosis related to various factors, such immune abnormalities, endocrine disorders, brain-gut axis, angiogenesis, mechanical stimulation. These factors induce systemic chronic inflammation, which stimulates nerves subsequently alters neural plasticity, leading nociceptive sensitization thereby causing pain. In this paper, we compile review articles published on study mechanisms. Starting from influencing associated explain relationship between these inflammation further elaborate potential by induces sensitization. We aim reveal possible pain, well sensitization, offer new targets for treatment

Language: Английский

Citations

0
Associations of ambient fine particulate matter with lung function and nasal microbiota: A panel study in asthmatic children DOI
Chang Huang,

Wen He,

Lijuan Liu

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126084 - 126084

Published: March 1, 2025

Language: Английский

Citations

0
Microbiome landscapes of the bladder, intestine, and vagina in bladder cancer: a systematic review DOI Creative Commons
Jonathan Surber, Marie Semmler,

Dominik Enderlin

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 14, 2025

Microbiomes have been linked to oncogenesis, e.g. the intestinal microbiome and colon cancer or HPV-associated cervical cancer. A connection between microbiomes of different body cavities tumor oncogenesis was shown. The gut microbiome's influence on bladder established, raising question whether nearby (rectum, vagina) also due their proximity. Considering various broader microbial components, this systematic review aims investigate differences in bladder, vaginal, microbiota-including bacterial, viral, fungal archaea-between patients with healthy controls. Databases (PubMed, Scopus, Embase) were searched until April 2022. Three types studies included: "(1) using control groups (case-controlled studies) (2) that provided information presence abundance taxa (3) increased decreased and/or groups.". Risk bias assessed Newcastle Ottawa Scale. Fourteen (695 samples: 403 cancer, 292 controls) analyzed. Bacterial detected at least two studies, genera Geobacillus Rubrobacter more frequently patients; while Streptococcus Roseomonas prevalent No consistent identified across stool tissue samples. microbiota show significant variation studies. Standardized methods expanded investigations into viral components are needed clarify role

Language: Английский

Citations

0
Interruptins Extracted from Cyclosorus terminans Protect Gut Pathologies Induced by High-Fat Diet in Rats DOI Open Access
Chanisa Thonusin, Kanokphong Suparan, Chanon Kunasol

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1387 - 1387

Published: April 20, 2025

Background/Objectives: The fern “Cyclosorus terminans” (C. terminans) or “Maiden Fern” contains interruptin A and B. This plant could attenuate obesity, insulin resistance, fatty liver in rats fed a high-fat/calorie diet. However, the benefits of C. terminans to gut remain unknown. We investigated protective effect extract against dysfunction exposed Methods: Male Wistar were assigned receive either (1) normal diet treated with vehicle, (2) (3) 100 mg per kg day (mg·kg−1·day−1) extract, (4) 200 mg·kg−1·day−1 extract. euthanized after 12 weeks treatment enable feces colon tissue collection. Results: Both reduced body weight (−10.49%; p = 0.030 −10.54%; 0.037, respectively) ameliorated inflammation, barrier disruption, changes short-chain acid levels, dysbiosis caused by Conclusions: attenuated an increase exerted prophylactic effects pathologies induced

Language: Английский

Citations

0