Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract INTRODUCTION Cerebrovascular dysfunction plays a critical role in the pathogenesis of dementia and related neurodegenerative disorders. Recent omics‐driven research has revealed associations between vascular abnormalities transcriptomic alterations brain cells, particularly endothelial cells (ECs) pericytes (PCs). However, impact these molecular changes on remains unclear. METHODS We conducted comparative analysis gene expression ECs PCs across conditions, including Alzheimer's disease (AD), Huntington's disease, arteriovenous malformation, utilizing data from published postmortem human tissue studies. RESULTS identified differentially expressed genes (DEGs) consistently dysregulated pathologies. Notably, several DEGs are linked to cell zonation genetic risks for AD cerebral small vessel disease. DISCUSSION Our findings provide insights into cellular mechanisms underlying dementia, highlight knowledge gaps, suggest potential novel therapeutic targets, not previously investigated this context. Highlights Systematic review single‐nuclear RNA‐sequencing (snRNA‐seq) Identify overlapping multiple types Examine functional relevance with risk common DEGs. Outline future directions omics field.

Language: Английский

Identification of critical genes and drug repurposing targets in entorhinal cortex of Alzheimer’s disease

Neurogenetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 10, 2025

Language: Английский