Antifungal Efficacy of Luliconazole-Loaded, Nanostructured Lipid-Carrier Gel in an Animal Model of Dermatophytosis DOI Creative Commons

Robab Ebrahimi Barogh,

Seyyed Mobin Rahimnia,

Mohsen Nosratabadi

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(4), P. 324 - 324

Published: April 19, 2025

Background: Trichophyton indotineae terbinafine-resistant infections are emerging in healthy individuals. Luliconazole, an imidazole antifungal that is effective against skin infections, faces challenges due to low water solubility and poor penetration. This study aimed formulate a luliconazole-loaded nanostructured lipid-carrier (NLC) gel Carbopol-based system enhance drug absorption efficacy guinea pig model of dermatophytosis. Methods: Luliconazole-loaded lipid carriers (NLCs) were prepared using solvent evaporation method formulation. Skin retention assessed via Franz diffusion cells. The was tested T. thirty pigs with induced tinea corporis, divided into five treatment groups. Mycological, clinical, histopathological evaluations conducted, along irritation studies for safety. Results: LCZ-NLC demonstrated significantly better penetration than simple luliconazole gel, cumulative 71.8 ± 3.7 μg/cm2 versus 50.9 4.2 after 24 h. Both formulations achieved complete infection resolution 21 28 days, reduced inflammation no local irritations. On day 21, the 1% lesion scores mycological evidence compared terbinafine-treated groups, untreated controls, NLC-gel-treated group (p < 0.05). Histopathological analysis indicated reduction both epidermal thickening fungal burden models received gel. Conclusions: efficacy, suggesting shorter durations improved patient outcomes resistant infections. However, further warranted correlate these findings clinical outcomes.

Language: Английский

Antifungal Efficacy of Luliconazole-Loaded, Nanostructured Lipid-Carrier Gel in an Animal Model of Dermatophytosis DOI Creative Commons

Robab Ebrahimi Barogh,

Seyyed Mobin Rahimnia,

Mohsen Nosratabadi

et al.

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(4), P. 324 - 324

Published: April 19, 2025

Background: Trichophyton indotineae terbinafine-resistant infections are emerging in healthy individuals. Luliconazole, an imidazole antifungal that is effective against skin infections, faces challenges due to low water solubility and poor penetration. This study aimed formulate a luliconazole-loaded nanostructured lipid-carrier (NLC) gel Carbopol-based system enhance drug absorption efficacy guinea pig model of dermatophytosis. Methods: Luliconazole-loaded lipid carriers (NLCs) were prepared using solvent evaporation method formulation. Skin retention assessed via Franz diffusion cells. The was tested T. thirty pigs with induced tinea corporis, divided into five treatment groups. Mycological, clinical, histopathological evaluations conducted, along irritation studies for safety. Results: LCZ-NLC demonstrated significantly better penetration than simple luliconazole gel, cumulative 71.8 ± 3.7 μg/cm2 versus 50.9 4.2 after 24 h. Both formulations achieved complete infection resolution 21 28 days, reduced inflammation no local irritations. On day 21, the 1% lesion scores mycological evidence compared terbinafine-treated groups, untreated controls, NLC-gel-treated group (p < 0.05). Histopathological analysis indicated reduction both epidermal thickening fungal burden models received gel. Conclusions: efficacy, suggesting shorter durations improved patient outcomes resistant infections. However, further warranted correlate these findings clinical outcomes.

Language: Английский

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