Overcoming aminoglycoside antibiotic resistance in Mycobacterium tuberculosis by targeting Eis protein

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 4, 2025

Language: Английский

Development of a novel multiepitope vaccine against Menangle virus (MenV) using in-silico approaches by targeting its transmembrane proteins

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 21, 2025

Menangle Virus (MenV) is a zoonotic pathogenic virus that can penetrate humans, causing infection in them. It an essential threat to public health due the possibility of cross-species transmissions. Traditional vaccine development methods are time-consuming and resource-intensive, highlighting need for innovative approaches. This study uses computational techniques develop multiepitope MenV. We employed silico tools find potential B-cell, T-cell, MHC-binding epitopes viral proteome. To ensure their safety efficacy, these were evaluated antigenicity, allergenicity, toxicity. The selected assembled into construct optimized molecular stability immunogenicity. Studies docking MD simulations considered assess interaction candidates with human receptors, indicating strong immune response. goal developing this prepare future outbreaks. in-silico design proposes promising, efficient path effective preventative measures against MenV, potentially expediting production contributing world security.

Language: Английский

Curcumin Inhibits Lipopolysaccharide-Induced Inflammation Through the HMGB1/NF-κB Signaling Pathway to Promote the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский