Sodium aescinate promotes apoptosis of pancreatic stellate cells and alleviates pancreatic fibrosis by inhibiting the PI3K/Akt/FOXO1 signaling pathways DOI Creative Commons
Qingyun Wang, Bin Xu, Yi Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Chronic pancreatitis (CP) is an inflammatory disease of progressive pancreatic fibrosis, and stellate cells (PSCs) are key involved in fibrosis. To date, there no clinical therapies available to reverse damage or fibrosis associated with CP. Sodium Aescinate (SA) a natural mixture triterpene saponins extracted from the dried ripe fruits horse chestnut tree. It has been shown have anti-inflammatory anti-edematous effects. This study aims explore therapeutic potential SA CP molecular mechanism its modulation. Through vivo animal models experiments, we found that significantly alleviated inflammation caerulein-induced mice model. In addition, inhibited proliferation, migration activation PSCs as well promoted apoptosis through series experiments on vitro including CCK-8 assay, Western blotting, immunofluorescence staining, wound-healing Transwell assays, flow cytometric analysis, etc. Further RNA sequencing validation assays revealed inhibition PI3K/AKT/FOXO1 signaling pathway was mediated promotion apoptosis, thus alleviating conclusion, this may promising agent for treatment CP, target

Language: Английский

Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway DOI
Xin Zheng,

Xinyi Tang,

Yinan Xu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119608 - 119608

Published: March 1, 2025

Language: Английский

Citations

0
Sodium aescinate promotes apoptosis of pancreatic stellate cells and alleviates pancreatic fibrosis by inhibiting the PI3K/Akt/FOXO1 signaling pathways DOI Creative Commons
Qingyun Wang, Bin Xu, Yi Wang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 22, 2025

Chronic pancreatitis (CP) is an inflammatory disease of progressive pancreatic fibrosis, and stellate cells (PSCs) are key involved in fibrosis. To date, there no clinical therapies available to reverse damage or fibrosis associated with CP. Sodium Aescinate (SA) a natural mixture triterpene saponins extracted from the dried ripe fruits horse chestnut tree. It has been shown have anti-inflammatory anti-edematous effects. This study aims explore therapeutic potential SA CP molecular mechanism its modulation. Through vivo animal models experiments, we found that significantly alleviated inflammation caerulein-induced mice model. In addition, inhibited proliferation, migration activation PSCs as well promoted apoptosis through series experiments on vitro including CCK-8 assay, Western blotting, immunofluorescence staining, wound-healing Transwell assays, flow cytometric analysis, etc. Further RNA sequencing validation assays revealed inhibition PI3K/AKT/FOXO1 signaling pathway was mediated promotion apoptosis, thus alleviating conclusion, this may promising agent for treatment CP, target

Language: Английский

Citations

0